Disease relevance of anf-A

• Human neuroblastoma cells express a novel metallo-endopeptidase activity able to inactivate atrial natriuretic factor: inhibition during retinoic acid-induced differentiation [1].

High impact information on anf-A

• This enzyme, which has an apparent molecular mass of 100 kDa, performs a selective cleavage at the Xaa-Phe, Xaa-Leu, or Xaa-Ile bond (Xaa = Ser, Phe, Tyr, His, or Gly) of a number of peptide hormones, including atrial natriuretic factor, substance P, angiotensin II, bradykinin, somatostatin, neuromedins B and C, and litorin [2].
• Membrane currents elicited by prostaglandins, atrial natriuretic factor and oxytocin in follicle-enclosed Xenopus oocytes [3].
• In Xenopus oocytes, an initial step in progesterone-induced maturation is the reduction of intracellular cAMP levels; both ANF and 8-Br-cGMP lowered cAMP levels and enhanced progesterone's ability to do so [4].
• This decrease in cAMP levels was attributable to increased cAMP-phosphodiesterase activity, which was enhanced by both ANF and 8-Br-cGMP [4].
• Xenopus oocytes were found to express atrial natriuretic factor (ANF) receptors that activate guanylate cyclase and stimulate cyclic guanosine 5'-monophosphate (cGMP) production in a dose- and time-dependent manner [4].

Biological context of anf-A

• The co-localization of dense binding sites for both peptides in the nucleus habenularis, hypophyseal pars nervosa and pars distalis supports the view that ANF and A II have opposite regulatory functions in these regions [5].
• The osmotic stress of acclimation to 1.5% salt water increased renal but not adrenal ANF binding [6].

Anatomical context of anf-A

• Localization of binding sites for atrial natriuretic factor and angiotensin II in the central nervous system of the clawed toad Xenopus laevis [5].
• Characterization of embryonic expression indicates that the ANF gene is initially expressed throughout the developing myocardium at the late heart tube stage (about stage 32) [7].
• Moderate ANF-binding was found in the bulbus olfactorius, pallium, septum, striatum, lateral forebrain bundle, nucleus infundibularis, hypophyseal pars distalis and tectum [5].
• ANF is concluded to act on steroidogenic but not chromaffin cells in Xenopus laevis [8].

Associations of anf-A with chemical compounds

• In addition, preincubation with ANF increased the number of oocytes that underwent progesterone-induced maturation [4].
• Atrial natriuretic factor activates cyclic adenosine 3',5'-monophosphate phosphodiesterase in Xenopus laevis oocytes and potentiates progesterone-induced maturation via cyclic guanosine 5'-monophosphate accumulation [4].
• These results suggest that ANF potentiates glibenclamide-sensitive K+ currents via the activation of receptor guanylate cyclase and consequent accumulation of cGMP in follicle-enclosed Xenopus oocytes [9].
• K+ currents induced by the K+ channel opener Y-26763 were potentiated by ANF (0.5-50 nM) in a concentration-dependent manner [9].
• Only ANF analogues with intact disulfide bridges (rANF(99-126), hANF(99-126), Atriopeptin II, frogANF(21)), and an extract of Xenopus laevis hearts significantly inhibited aldosterone release; the N-terminal (99-109) and the C-terminal ANF(116-126) fragments had no effects [8].

Analytical, diagnostic and therapeutic context of anf-A

• The distribution of binding sites for atrial natriuretic factor (ANF) and angiotensin II (A II) was investigated in the central nervous system (CNS) of the clawed toad Xenopus laevis by means of in vitro autoradiography using [125I]-rat ANF(99-126) or [125I] [Val5] A II and [125I]human A II as labeled ligands [5].

References