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Chemical Compound Review

Litorine     (2S)-N-[(1S)-1-[[(1S)-1- [[(1S)-1-[[(1S)-1...

Synonyms: AC1NUOTY, 55749-97-8, Ranatesin, 2-de-L-valine-3-de-L-proline-
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Disease relevance of Litorine


Psychiatry related information on Litorine


High impact information on Litorine


Biological context of Litorine


Anatomical context of Litorine

  • 2 Litorin proved to be more potent than bombesin on isolated smooth muscle preparations and on the urinary bladder in situ [14].
  • 5 In its effects on the myo-electric activity of the dog duodenum (inhibition of spikes and increase in frequency of pacesetter potentials leading to the appearance of a sequence of slow and small potentials) litorin possessed approximately 50 to 70% of the activity of bombesin [14].
  • These findings suggest that litorin acts on the hypothalamus to inhibit TRH release, and that its effects are modified by amines of the central nervous system [15].
  • 1. Low levels of bombesin-like immunoreactivity (less than 1.10 pmol/g tissue), eluting at the same position as synthetic bombesin and litorin, have been measured in muscle and mucosa of the gastrointestinal canal of the cod, Gadus morhua [16].
  • In dispersed acini prepared from guinea pig pancreas, peptides isolated from amphibian skin (caerulein, bombesin, litorin, and physalaemin) as well as eledoisin, a peptide isolated from the posterior salivary gland of a Mediterranean octopod, caused a significant increase in amylase release [17].

Gene context of Litorine

  • B9 released significantly more PP than either litorin of ranatensin (P less than 0.01) [1].
  • Bombesin caused significantly greater release of gastrin than a meal, litorin or ranatensin (P less than 0.01) [1].
  • 3 Gastrin release and acid secretion produced by litorin was more rapid in onset but less intense and less sustained than that elicited by bombesin [14].
  • 4 Gall bladder contraction stimulated by litorin was probably caused by a double action of the peptide, directly on the bladder smooth muscle, and indirectly by cholecystokinin release [14].
  • The hypothalamic immunoreactive TRH (ir-TRH) content increased significantly after litorin injection, whereas its plasma concentration tended to decrease, but not significantly [15].

Analytical, diagnostic and therapeutic context of Litorine


  1. Stimulation of canine pancreatic polypeptide, gastrin, and gastric acid secretion by ranatensin, litorin, bombesin nonapeptide and substance P. Modlin, I.M., Lamers, C.B., Walsh, J.H. Regul. Pept. (1981) [Pubmed]
  2. Litorine: a new macrolide antimicrobial isolated from Littorina aspera. Perez Gutierrez, R.M., Stawinski, T., Osnaya Mendoza, D.R. Drugs under experimental and clinical research. (1987) [Pubmed]
  3. Drinking and feeding inhibition by ICV pulse injection or infusion of bombesin, ranatensin and litorin to rats. de Caro, G., Massi, M., Micossi, L.G., Perfumi, M. Peptides (1984) [Pubmed]
  4. Litorin suppresses food intake in rats. Kulkosky, P.J., Gibbs, J. Life Sci. (1982) [Pubmed]
  5. Litorin and litorin-albumin conjugate as effective regulators of body temperature in rats. Esakov, A.I., Ashmarin, I.P., Serova, O.N., Obukhova, M.F., Storozheva, Z.I., Golubovich, V.P., Kuznetsova, N.V. Biomed. Sci. (1990) [Pubmed]
  6. Bombesin stimulation of DNA synthesis and cell division in cultures of Swiss 3T3 cells. Rozengurt, E., Sinnett-Smith, J. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  7. Activation of neuromedin B-preferring bombesin receptors on rat glioblastoma C-6 cells increases cellular Ca2+ and phosphoinositides. Wang, L.H., Battey, J.F., Wada, E., Lin, J.T., Mantey, S., Coy, D.H., Jensen, R.T. Biochem. J. (1992) [Pubmed]
  8. Bombesin stimulates prolactin and growth hormone release by pituitary cells in culture. Westendorf, J.M., Schonbrunn, A. Endocrinology (1982) [Pubmed]
  9. Characterization of bombesin receptors in peripheral contractile organs. Rouissi, N., Rhaleb, N.E., Nantel, F., Dion, S., Drapeau, G., Regoli, D. Br. J. Pharmacol. (1991) [Pubmed]
  10. Rohdei-litorin: a new peptide from the skin of Phyllomedusa rohdei. Barra, D., Falconieri Erspamer, G., Simmaco, M., Bossa, F., Melchiorri, P., Erspamer, V. FEBS Lett. (1985) [Pubmed]
  11. Satiety and scratching; effects of bombesin-like peptides. Negri, L. Eur. J. Pharmacol. (1986) [Pubmed]
  12. Characterization and distribution of bombesin binding sites in the goldfish hypothalamic feeding center and pituitary. Himick, B.A., Vigna, S.R., Peter, R.E. Regul. Pept. (1995) [Pubmed]
  13. Parallel bioassay of litorin and Glu(OMe)2-litorin on smooth muscle preparations and blood pressure. Erspamer, G.F., Piccinelli, D. J. Pharm. Pharmacol. (1980) [Pubmed]
  14. Parallel bioassay of bombesin and litorin, a bombesin-like peptide from the skin of Litoria aurea. Endean, R., Erspamer, V., Falconieri Erspamer, G., Improta, G., Melchiorri, P., Negri, L., Sopranzi, N. Br. J. Pharmacol. (1975) [Pubmed]
  15. Litorin (bombesin family) inhibits thyrotropin secretion in rats. Mitsuma, T., Nogimori, T., Sun, D.H., Chaya, M. Exp. Clin. Endocrinol. (1986) [Pubmed]
  16. Occurrence and effects on motility of bombesin related peptides in the gastrointestinal tract of the Atlantic cod, Gadus morhua. Holmgren, S., Jönsson, A.C. Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. (1988) [Pubmed]
  17. Actions of peptides isolated from amphibian skin on amylase release from dispersed pancreatic acini. Uhlemann, E.R., Rottman, A.J., Gardner, J.D. Am. J. Physiol. (1979) [Pubmed]
  18. Neuropeptides and cerebral electric activity in rabbits. Tartara, A., Bo, P., Savoldi, F. Peptides (1982) [Pubmed]
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