Disease relevance of INS

• Also their application for the determination of zinc in insulin to control injection quality and magnesium in human urine for the diagnosis and treatment of magnesium deficiency was shown [1].

High impact information on INS

• Triiodothyronine stimulates transcription of the fatty acid synthase gene in chick embryo hepatocytes in culture. Insulin and insulin-like growth factor amplify that effect [2].
• To determine the role of s-myotrophin in skeletal muscle growth, the effect of s-myotrophin on primary cultured chick skeletal muscle cells (composed almost totally of multinucleated myotubes) was investigated by comparing s-myotrophin with Insulin-like growth factor-I (IGF-I) [3].
• The plasma insulin to glucagon molar ratio of incubation from 14E to 17E ranged from 2 to 4, and was significantly higher than at any other time during incubation [4].
• Developmental Changes of Plasma Insulin, Glucagon, Insulin-like Growth Factors, Thyroid Hormones, and Glucose Concentrations in Chick Embryos and Hatched Chicks [4].
• Insulin and glucagon increased after hatch, which may be due to increased feed consumption and increased utilization of carbohydrates as the key energy source, compared with nutrients obtained through lipolysis and proteolysis in the embryos [4].

Biological context of INS

• Developmental hormonal changes in Cobb 500 chick embryos and hatched chicks were determined by measuring plasma insulin, glucagon, insulin-like growth factor (IGF)-I, IGF-II, triiodothyronine, thyroxine, and glucose concentrations at different ages of embryogenesis and posthatch development [4].
• The purpose of the present study was to analyze association of the insulin (INS) gene with chicken growth and body composition traits [5].
• Therefore, the divergence of IGF-I and INS seems to have occurred early in vertebrate phylogeny [6].
• Using a F2 design resource population constructed with the crossing of Chinese native Xinghua chickens and White Recessive Rock chickens, the association of 4 single nucleotide polymorphisms (SNP; A+428G, C+1549T, T+3737C, and A+3971G) of INS gene with 13 growth and body composition traits was studied [5].
• 4. Insulin did not inhibit basal or glucagon-stimulated glycogenolysis [7].

Associations of INS with chemical compounds

• The same increase in dietary protein increased (P less than 0.05) both insulin (INS) and thyroxine (T4) and decreased (P less than 0.05) triiodothyronine (T3) [8].
• 3. Insulin significantly enhanced enzyme activity when added to the culture medium at a 10(-9) M concentration, and a small stimulating effect was also observed with 10(-6) M dexamethasone [9].
• 3. Insulin decreased the incorporation of the infused glutamine amide-15N into urinary uric acid as well as the excretion of other N-derived urinary uric acid (P less than 0.05), which resulted in a significant decrease in total urinary uric acid (P less than 0.05) [10].
• EGF, IGF-I (Insulin-like Growth Factor-I), or PDGF (Platelet-derived Growth Factor) alone increased [3H]thymidine incorporation in the cells [11].

References