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Gene Review:

LOC396380 - glutathione transferase

Gallus gallus

Morgenstern, R. et al., Padmaja, K. et al., Makar, T.K. et al., Chen, J.C. et al., Zimniak, P. et al., et al.

Bolton, Curstedt, Cederlund, Hjelmqvist, Mannervik, Ahokas, Jörnvall,

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Disease relevance of LOC396380

However, the toxicity caused by tryptamine-4,5-dione and glutathione conjugate could not be blocked by fluoxetine (10 or 100 microM) or by a glutathione transferase inhibitor, boric acid/serine [1].

High impact information on LOC396380

The high activity of rat glutathione transferase 8-8 with alkene substrates is dependent on a glycine residue in the active site [2].
These included gamma-glutamylcysteine synthetase, GSH synthetase, gamma-glutamyl cyclotransferase, gamma-glutamyltranspeptidase, glutathione transferase (GST), GSH peroxidase, and GSSG reductase [3].
Characterization of a marsupial glutathione transferase, a class Alpha enzyme from Brown Antechinus (Antechinus stuartii) [4].
Members of the subgroup, which also include the rat GST 8-8 and perhaps chicken GST CL3, show high sequence homology with each other, but only moderate similarity to other alpha class enzymes [5].
The distribution of microsomal glutathione transferase among different organelles, different organs, and different organisms [6].

Biological context of LOC396380

Toad was the only species that had a notable (twofold) sex difference in their level of hepatic microsomal glutathione transferase activity [6].

Anatomical context of LOC396380

Of those mammals for which fresh liver could be obtained, all demonstrated N-ethylmaleimide-activatable glutathione transferase activity in their liver microsomes [6].
Microsomal glutathione transferase present in other subcellular fractions can be accounted for by contamination by the endoplasmic reticulum [6].
In contrast to the situation with rat liver microsomes the glutathione transferase activities of microsomes from extrahepatic tissues of this same animal could not be activated by treatment with N-ethylmaleimide [6].

Associations of LOC396380 with chemical compounds

In the present study we have used both enzyme assay with 1-chloro-2,4-dinitrobenzene as substrate and immunochemical quantitation to examine the distribution of microsomal glutathione transferase in different organelles, in different organs, and in different organisms [6].

Other interactions of LOC396380

Further, the effect of Se on some of the antioxidant enzymes like glutathione peroxidase (GPx), glutathione transferase (GST), glutathione reductase (GR), superoxide dismutase (SOD) and catalase were studied [7].

References

Neurotoxicity of free-radical-mediated serotonin neurotoxin in cultured embryonic chick brain neurons. Chen, J.C., Fine, R.E., Squicciarini, J., Volicer, L. Eur. J. Pharmacol. (1996) [Pubmed]
The high activity of rat glutathione transferase 8-8 with alkene substrates is dependent on a glycine residue in the active site. Björnestedt, R., Tardioli, S., Mannervik, B. J. Biol. Chem. (1995) [Pubmed]
Vitamin E, ascorbate, glutathione, glutathione disulfide, and enzymes of glutathione metabolism in cultures of chick astrocytes and neurons: evidence that astrocytes play an important role in antioxidative processes in the brain. Makar, T.K., Nedergaard, M., Preuss, A., Gelbard, A.S., Perumal, A.S., Cooper, A.J. J. Neurochem. (1994) [Pubmed]
Characterization of a marsupial glutathione transferase, a class Alpha enzyme from Brown Antechinus (Antechinus stuartii). Bolton, R.M., Curstedt, L., Cederlund, E., Hjelmqvist, L., Mannervik, B., Ahokas, J.T., Jörnvall, H. FEBS Lett. (1997) [Pubmed]
A subgroup of class alpha glutathione S-transferases. Cloning of cDNA for mouse lung glutathione S-transferase GST 5.7. Zimniak, P., Eckles, M.A., Saxena, M., Awasthi, Y.C. FEBS Lett. (1992) [Pubmed]
The distribution of microsomal glutathione transferase among different organelles, different organs, and different organisms. Morgenstern, R., Lundqvist, G., Andersson, G., Balk, L., DePierre, J.W. Biochem. Pharmacol. (1984) [Pubmed]
Inhibition of lipid peroxidation by selenium in chick embryos. Padmaja, K., Somasekharaiah, B.V., Prasad, A.R. Drug and chemical toxicology. (1997) [Pubmed]

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GSTA	Gallus gallus
GSTA2	Homo sapiens
LOC462769	Pan troglodytes
LOC501110	Rattus norvegicus

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