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Gene Review

FOLR1  -  folate receptor 1 (adult)

Sus scrofa

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Disease relevance of FBP

  • Finally, N-terminal amino acid sequencing of FBP purified from Day 15 pregnant uterine flushings matched the secreted form of FBP mRNA [1].

High impact information on FBP

  • On the basis of the absence or presence of an intact glycophosphatidylinositol linkage site in the C terminus of the predicted amino acid sequences, the two forms appear to encode secreted and membrane-bound forms of FBP [1].
  • These results suggest a role for FBP in the delivery of folate to the developing conceptus [2].
  • These results indicate that an FBP similar to other known FBPs is present in uterine flushings and allantoic fluid and that its level increases at about the time of blastocyst elongation and initiation of conceptus hematopoiesis [2].
  • The FBP reacted more rapidly with unsubstituted folates, and the number of glutamic acid moieties (N greater than or equal to 1) did not influence binding [3].
  • Binding of folic acid to the FBP was unaffected by a variety of anions and cations, and 8 M urea, but was disrupted by 6 M guanidine hydrochloride [3].

Chemical compound and disease context of FBP

  • Uterine flushings were collected on d 10, 11, 12, 13, 14, and 15 of the cycle or pregnancy from 1) White crossbred, 2) progesterone-treated White crossbred (200 mg of progesterone at 48 and 72 h after estrus), and 3) Meishan gilts and assayed for FBP [4].

Anatomical context of FBP


Associations of FBP with chemical compounds


Other interactions of FBP


Analytical, diagnostic and therapeutic context of FBP

  • Northern blots of endometrial total RNA probed with a putative secreted FBP specific probe indicated that mRNA concentrations do not change during early pregnancy [1].
  • Antiserum to the purified allantoic fluid FBP was generated in rabbits and used for immunoblotting [2].
  • Folate-binding proteins (FBP) from Day 60 pseudopregnant uterine flushings and Day 60 allantoic fluid were purified by affinity chromatography on folate-Sepharose followed by G-100 Sephadex chromatography [2].


  1. Isolation of complementary deoxyribonucleic acids encoding putative secreted and membrane-bound folate binding proteins from endometrium of swine. Vallet, J.L., Smith, T.P., Sonstegard, T., Pearson, P.L., Christenson, R.K., Klemcke, H.G. Biol. Reprod. (1999) [Pubmed]
  2. Purification and characterization of intrauterine folate-binding proteins from swine. Vallet, J.L., Christenson, R.K., Klemcke, H.G. Biol. Reprod. (1998) [Pubmed]
  3. Properties of a folate binding protein (FBP) isolated from porcine kidney. Kamen, B.A., Caston, J.D. Biochem. Pharmacol. (1986) [Pubmed]
  4. A radioimmunoassay for porcine intrauterine folate binding protein. Vallet, J.L., Christenson, R.K., Klemcke, H.G. J. Anim. Sci. (1999) [Pubmed]
  5. Intravenous infusion of iron and tetrahydrofolate does not influence intrauterine uteroferrin and secreted folate-binding protein content in swine. Vallet, J.L., Christenson, R.K., Klemcke, H.G., Pearson, P.L. J. Anim. Sci. (2001) [Pubmed]
  6. Allelic variation in the secreted folate binding protein gene is associated with uterine capacity in swine. Vallet, J.L., Freking, B.A., Leymaster, K.A., Christenson, R.K. J. Anim. Sci. (2005) [Pubmed]
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