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Gene Review

FBP1  -  fructose-1,6-bisphosphatase 1

Bos taurus

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Disease relevance of FBP


High impact information on FBP


Biological context of FBP

  • In this report we describe a novel finding that the 104 kDa chaperone protein exhibits affinity for iron containing proteins such as transferrins from several species, human lactoferrin and microbial ferric binding protein (FBP) [8].
  • Stabilization of milk folates may be a role of FBP and would improve the bioavailability of milk folate to newborns and other consumers [9].
  • Native state FBP recently has been shown to enhance the intestinal absorption of folacin, whereas the FBP of pasteurized milk is ineffective [10].
  • The technique was applied to the measurement of active FBP content of consumer milks, the heat classification of skim milk powders manufactured under a wide range of thermal processing protocols, and change during early bovine lactation [11].
  • The amide I region pointed to a beta-sheet to alpha-helix transition upon ligation in acetate and phosphate buffers, and the formation of intermolecular beta-sheet was indicated at pH 5.0, in agreement with a dimerization of FBP taking place at this pH [12].

Anatomical context of FBP


Associations of FBP with chemical compounds


Other interactions of FBP


Analytical, diagnostic and therapeutic context of FBP

  • Folate binding protein was purified from cow's milk by a combination of cation exchange chromatography and methotrexate-AH-sepharose affinity chromatography [16].
  • Anion-exchange chromatography indicated no major electrostatic differences in the FBP of these products, although gel-filtration chromatography provided evidence of enhanced FBP aggregation in the pasteurized whey protein concentrate [10].
  • The HPLC and sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) results indicate the formation of three complexes after the binding of G5.75Ac-FA4 with FBP [20].
  • We used rabbit anti-bovine milk antibody and ELISA to measure FBP [21].
  • A longitudinal study will determine if these changes in FBP concentrations precede tumor onset [21].


  1. Isolation and enumeration of Campylobacter jejuni from poultry products by a selective enrichment method. Wesley, R.D., Swaminathan, B., Stadelman, W.J. Appl. Environ. Microbiol. (1983) [Pubmed]
  2. Serum antibodies to cow's milk folate-binding protein in patients with chronic inflammatory bowel disease. Høier-Madsen, M., Holm, J., Hansen, S.I., Nielsen, O.H. International journal of tissue reactions. (1989) [Pubmed]
  3. Homologous membrane folate binding proteins in human placenta: cloning and sequence of a cDNA. Ratnam, M., Marquardt, H., Duhring, J.L., Freisheim, J.H. Biochemistry (1989) [Pubmed]
  4. Expression and differential polarization of the reduced-folate transporter-1 and the folate receptor alpha in mammalian retinal pigment epithelium. Chancy, C.D., Kekuda, R., Huang, W., Prasad, P.D., Kuhnel, J.M., Sirotnak, F.M., Roon, P., Ganapathy, V., Smith, S.B. J. Biol. Chem. (2000) [Pubmed]
  5. The complete amino acid sequence of a human folate binding protein from KB cells determined from the cDNA. Sadasivan, E., Rothenberg, S.P. J. Biol. Chem. (1989) [Pubmed]
  6. Chicken riboflavin-binding protein. cDNA sequence and homology with milk folate-binding protein. Zheng, D.B., Lim, H.M., Pène, J.J., White, H.B. J. Biol. Chem. (1988) [Pubmed]
  7. Bacteriophage T4 baseplate components. I. Binding and location of the folic acid. Kozloff, L.M., Lute, M., Crosby, L.K. J. Virol. (1975) [Pubmed]
  8. An estrogen inducible 104 kDa chaperone glycoprotein binds ferric iron containing proteins: a possible role in intracellular iron trafficking. Poola, I. FEBS Lett. (1997) [Pubmed]
  9. Tetrahydrofolates are greatly stabilized by binding to bovine milk folate-binding protein. Jones, M.L., Nixon, P.F. J. Nutr. (2002) [Pubmed]
  10. Denaturation of the folacin-binding protein in pasteurized milk products. Gregory, J.F. J. Nutr. (1982) [Pubmed]
  11. Direct optical biosensor analysis of folate-binding protein in milk. Indyk, H.E., Filonzi, E.L. J. Agric. Food Chem. (2004) [Pubmed]
  12. Application of near-infrared and Fourier transform infrared spectroscopy in the characterization of ligand-induced conformation changes in folate binding protein purified from bovine milk: influence of buffer type and pH. Bruun, S.W., Holm, J., Hansen, S.I., Jacobsen, S. Applied spectroscopy. (2006) [Pubmed]
  13. Effect of folate-binding protein on intestinal transport of folic acid and 5-methyltetrahydrofolate across Caco-2 cells. Verwei, M., van den Berg, H., Havenaar, R., Groten, J.P. European journal of nutrition. (2005) [Pubmed]
  14. Influence of goat's-milk folate-binding protein on transport of 5-methyltetrahydrofolate in neonatal-goat small intestinal brush-border-membrane vesicles. Salter, D.N., Blakeborough, P. Br. J. Nutr. (1988) [Pubmed]
  15. Megalin binds and mediates cellular internalization of folate binding protein. Birn, H., Zhai, X., Holm, J., Hansen, S.I., Jacobsen, C., Christensen, E.I., Moestrup, S.K. FEBS J. (2005) [Pubmed]
  16. Ligand binding characteristics and aggregation behavior of purified cow's milk folate binding protein depends on the presence of amphiphatic substances including cholesterol, phospholipids, and synthetic detergents. Holm, J., Hansen, S.I. Biosci. Rep. (2002) [Pubmed]
  17. Ligand-induced conformation change in folate-binding protein. Kaarsholm, N.C., Kolstrup, A.M., Danielsen, S.E., Holm, J., Hansen, S.I. Biochem. J. (1993) [Pubmed]
  18. A novel specific heparin-binding activity of bovine folate-binding protein characterized by capillary electrophoresis. Heegaard, N.H., Hansen, S.I., Holm, J. Electrophoresis (2006) [Pubmed]
  19. Determination of minor proteins of bovine milk and colostrum by optical biosensor analysis. Indyk, H.E., Filonzi, E.L., Gapper, L.W. Journal of AOAC International. (2006) [Pubmed]
  20. HPLC analysis of functionalized poly(amidoamine) dendrimers and the interaction between a folate-dendrimer conjugate and folate binding protein. Shi, X., Bi, X., Ganser, T.R., Hong, S., Myc, L.A., Desai, A., Holl, M.M., Baker, J.R. The Analyst. (2006) [Pubmed]
  21. Tissue folate binding protein levels in transgenic mice with tumors and in non-transgenic controls. Au, T.V., So-Lui, M.C., Zhang, Y., Arjomand, A., Lin, Y., Dueker, S.R., Ho, Y.K., Clifford, A.J. Comp. Biochem. Physiol. C, Pharmacol. Toxicol. Endocrinol. (1999) [Pubmed]
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