The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Gene Review

TTR  -  transthyretin

Sus scrofa

 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of TTR

 

High impact information on TTR

  • Fractional synthesis rates of retinol-binding protein, transthyretin, and a new peptide measured by stable isotope techniques in neonatal pigs [4].
  • A molecular phylogeny of the rodent superfamily Cavioidea was derived using two nuclear sequences (exon #10 of the growth hormone receptor gene and intron #1 of the transthyretin gene) and one mitochondrial gene (12S rRNA) [5].
  • In accordance with previous findings, TTR mRNA was found in the choroid plexus and, to a lesser extent, in the liver of all three species [1].
  • In addition low levels of TTR mRNA were identified in the rat and human pancreas [1].
  • Compared with controls, protein-deficient pigs had significantly lower (P < 0.05) plasma albumin, RBP and TTR2 concentrations, significantly slower (P < 0.05) FSR of fibrinogen, HDL-apoA-1, transferring and TTR2, significantly lower (P < 0.05) ASR of albumin, fibrinogen, transferrin, and TTR2, and a significantly higher (P < 0.05) ASR of TTR [6].
 

Biological context of TTR

 

Anatomical context of TTR

 

Associations of TTR with chemical compounds

 

Analytical, diagnostic and therapeutic context of TTR

  • Transthyretin (TTR) cDNA probes were used to determine the presence of TTR mRNA in Northern blots from rat, porcine, and human organs as well as from human endocrine tumors [1].

References

  1. Transthyretin messenger ribonucleic acid expression in the pancreas and in endocrine tumors of the pancreas and gut. Jacobsson, B., Carlström, A., Platz, A., Collins, V.P. J. Clin. Endocrinol. Metab. (1990) [Pubmed]
  2. The negative acute phase response of serum transthyretin following Streptococcus suis infection in the pig. Campbell, F.M., Waterston, M., Andresen, L.O., Sorensen, N.S., Heegaard, P.M., Eckersall, P.D. Vet. Res. (2005) [Pubmed]
  3. Interactions amongst plasma retinol-binding protein, transthyretin and their ligands: implications in vitamin A homeostasis and transthyretin amyloidosis. Raghu, P., Sivakumar, B. Biochim. Biophys. Acta (2004) [Pubmed]
  4. Fractional synthesis rates of retinol-binding protein, transthyretin, and a new peptide measured by stable isotope techniques in neonatal pigs. Sivakumar, B., Jahoor, F., Burrin, D.G., Frazer, E.M., Reeds, P.J. J. Biol. Chem. (1994) [Pubmed]
  5. Phylogenetic relationships, ecological correlates, and molecular evolution within the cavioidea (mammalia, rodentia). Rowe, D.L., Honeycutt, R.L. Mol. Biol. Evol. (2002) [Pubmed]
  6. Chronic protein deficiency differentially affects the kinetics of plasma proteins in young pigs. Jahoor, F., Bhattiprolu, S., Del Rosario, M., Burrin, D., Wykes, L., Frazer, M. J. Nutr. (1996) [Pubmed]
  7. Binding of thyroxine to pig transthyretin, its cDNA structure, and other properties. Duan, W., Richardson, S.J., Köhrle, J., Chang, L., Southwell, B.R., Harms, P.J., Brack, C.M., Pettersson, T.M., Schreiber, G. Eur. J. Biochem. (1995) [Pubmed]
  8. Transthyretin immunoreactivity in human and porcine liver, choroid plexus, and pancreatic islets. Jacobsson, B., Collins, V.P., Grimelius, L., Pettersson, T., Sandstedt, B., Carlström, A. J. Histochem. Cytochem. (1989) [Pubmed]
  9. C-13 NMR spectral studies of the thyroid hormone transport protein, transthyretin and the pancreatic insulin storage moiety, the zinc-insulin hexamer. Craik, D.J., Hall, J.G., Higgins, K.A. Biochem. Biophys. Res. Commun. (1987) [Pubmed]
  10. Clofibrate increases hepatic triiodothyronine (t3)- and thyroxine (t4)-glucuronosyltransferase activities and lowers plasma t3 and t4 concentrations in pigs. Luci, S., Kluge, H., Hirche, F., Eder, K. Drug Metab. Dispos. (2006) [Pubmed]
 
WikiGenes - Universities