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Gene Review:

NR3C2 - nuclear receptor subfamily 3, group C,...

Sus scrofa

Poletto, R. et al., Ward, M.R. et al., Iqbal, U. et al., Lim-Tio, S.S. et al., Liu, L. et al., et al.

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High impact information on NR3C2

Comparison of the interaction between the thyroid receptor and the GR, or the MR, distinguish two types of repression, only one of which is receptor-specific [1].
Dexamethasone-exposed male offspring exhibited reduced basal and activated plasma cortisol levels, which was associated with elevated hippocampal mineralocorticoid receptor (MR) mRNA and increased plasma testosterone [2].
GR, but not MR, mRNA expression was elevated in the hippocampus and dentate gyrus, whereas NR1 mRNA expression was increased in the CA1 and CA3 fields of the foetal hippocampus [3].
Effects of early weaning and social isolation on the expression of glucocorticoid and mineralocorticoid receptor and 11beta-hydroxysteroid dehydrogenase 1 and 2 mRNAs in the frontal cortex and hippocampus of piglets [4].
Electrically-stimulated release of glutamate and GABA, in the presence or absence of dexamethasone, as well as glucocorticoid and mineralocorticoid receptor mRNA expression, was determined in the hippocampus and prefrontal cortex of adult offspring of treated pregnant guinea pigs [5].

Biological context of NR3C2

Maternal dexamethasone treatment in late gestation alters glucocorticoid and mineralocorticoid receptor mRNA in the fetal guinea pig brain [6].

Anatomical context of NR3C2

MR-specific modulators include a centrally active alpha-2 adrenergic agonist and the thyroid receptor [1].
There was no effect of dex on GR or MR mRNA in the male fetuses [6].
Mineralocorticoid receptor mRNA in the limbic system and GR mRNA levels in the pars distalis were unaffected [7].
Because collagen accumulation correlates with constrictive remodeling and aldosterone has been implicated in collagen accumulation, we examined how aldosterone and the mineralocorticoid receptor antagonists spironolactone and eplerenone affect remodeling and collagen in porcine coronary and iliac arteries after angioplasty [8].

Analytical, diagnostic and therapeutic context of NR3C2

Differences in amounts of 11beta-HSD1, 11beta-HSD2, GR and MR mRNA were determined by quantitative real-time RT-PCR and data subjected to multivariate linear mixed model analysis [4].

References

Intracellular signaling pathways confer specificity of transactivation by mineralocorticoid and glucocorticoid receptors. Lim-Tio, S.S., Fuller, P.J. Endocrinology (1998) [Pubmed]
Maternal glucocorticoid treatment programs HPA regulation in adult offspring: sex-specific effects. Liu, L., Li, A., Matthews, S.G. Am. J. Physiol. Endocrinol. Metab. (2001) [Pubmed]
Chronic prenatal ethanol exposure increases glucocorticoid-induced glutamate release in the hippocampus of the near-term foetal Guinea pig. Iqbal, U., Brien, J.F., Kapoor, A., Matthews, S.G., Reynolds, J.N. J. Neuroendocrinol. (2006) [Pubmed]
Effects of early weaning and social isolation on the expression of glucocorticoid and mineralocorticoid receptor and 11beta-hydroxysteroid dehydrogenase 1 and 2 mRNAs in the frontal cortex and hippocampus of piglets. Poletto, R., Steibel, J.P., Siegford, J.M., Zanella, A.J. Brain Res. (2006) [Pubmed]
Chronic prenatal ethanol exposure alters glucocorticoid signalling in the hippocampus of the postnatal Guinea pig. Iqbal, U., Brien, J.F., Banjanin, S., Andrews, M.H., Matthews, S.G., Reynolds, J.N. J. Neuroendocrinol. (2005) [Pubmed]
Maternal dexamethasone treatment in late gestation alters glucocorticoid and mineralocorticoid receptor mRNA in the fetal guinea pig brain. Dean, F., Matthews, S.G. Brain Res. (1999) [Pubmed]
Prenatal glucocorticoid modifies hypothalamo-pituitary-adrenal regulation in prepubertal guinea pigs. Dean, F., Yu, C., Lingas, R.I., Matthews, S.G. Neuroendocrinology (2001) [Pubmed]
Eplerenone suppresses constrictive remodeling and collagen accumulation after angioplasty in porcine coronary arteries. Ward, M.R., Kanellakis, P., Ramsey, D., Funder, J., Bobik, A. Circulation (2001) [Pubmed]

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