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Gene Review

TNC  -  tenascin C

Sus scrofa

Synonyms: GMEM, HXB, JI, P230, TN
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Disease relevance of TNC


High impact information on TNC


Biological context of TNC


Anatomical context of TNC

  • In fetuses, the tenascin-C signal in the brain was higher than the signal in the brain of adult, whereas the reverse was true for the adrenal gland and the colon [9].
  • In contrast, the amount of tenascin-C transcripts in the fetal brain and adult spinal cord was higher than those for tenascin-X [9].
  • We found that, in the healed fibrotic dermis and underlying muscle fibrosis, the amount of TN-C mRNA was increased up to 18- and 39-fold, respectively, compared to normal dermis, whereas the level of TN-X mRNA remained almost unchanged [2].
  • The immunohistochemical study revealed a significantly decreased number of neointimal macrophages and neovascularizations (p < 0.05, p < 0.01, respectively), and a stronger expression of tenascin-C in the radius [10].
  • Whereas pig normal skin displayed a discrete TN-C signal at the dermo-epidermal junction, around blood vessels and hair bulbs, the swine tumour showed enhanced expression of TN-C in these areas and around stromal and tumour cells [3].

Associations of TNC with chemical compounds

  • Optical intensity and color analyses showed significantly higher tenascin R and tenascin C expression in the MSC and BM groups than in the MI-only or Control group (P < 0.01) [11].

Other interactions of TNC

  • Overall, the tenascin-X gene was significantly expressed in two thirds of the tissues, and the tenascin-C gene in about 50% of them [9].

Analytical, diagnostic and therapeutic context of TNC

  • In analyses by Western blotting, the two main TN-C isoforms of 235-240 and 190-200 kDa increased up to 45- and 105-fold in fibrotic tissues, respectively [2].
  • CONCLUSIONS: Increased production of ECM, especially tenascin-C, played a greater role in the neointimal formation in the radius stent than inflammation [10].
  • This opposite regulation of TN-C and TN-X RNAs was confirmed at the protein level by indirect immunofluorescence [3].


  1. Altered hemodynamics controls matrix metalloproteinase activity and tenascin-C expression in neonatal pig lung. Jones, P.L., Chapados, R., Baldwin, H.S., Raff, G.W., Vitvitsky, E.V., Spray, T.L., Gaynor, J.W. Am. J. Physiol. Lung Cell Mol. Physiol. (2002) [Pubmed]
  2. Unlike tenascin-X, tenascin-C is highly up-regulated in pig cutaneous and underlying muscle tissue developing fibrosis after necrosis induced by very high-dose gamma radiation. Geffrotin, C., Tricaud, Y., Crechet, F., Castelli, M., Lefaix, J.L., Vaiman, M. Radiat. Res. (1998) [Pubmed]
  3. Opposite regulation of tenascin-C and tenascin-X in MeLiM swine heritable cutaneous malignant melanoma. Geffrotin, C., Horak, V., Créchet, F., Tricaud, Y., Lethias, C., Vincent-Naulleau, S., Vielh, P. Biochim. Biophys. Acta (2000) [Pubmed]
  4. Tenascin-C binds heparin by its fibronectin type III domain five. Weber, P., Zimmermann, D.R., Winterhalter, K.H., Vaughan, L. J. Biol. Chem. (1995) [Pubmed]
  5. DNA delivery from an intravascular stent with a denatured collagen-polylactic-polyglycolic acid-controlled release coating: mechanisms of enhanced transfection. Perlstein, I., Connolly, J.M., Cui, X., Song, C., Li, Q., Jones, P.L., Lu, Z., DeFelice, S., Klugherz, B., Wilensky, R., Levy, R.J. Gene Ther. (2003) [Pubmed]
  6. Antifibrotic action of Cu/Zn SOD is mediated by TGF-beta1 repression and phenotypic reversion of myofibroblasts. Vozenin-Brotons, M.C., Sivan, V., Gault, N., Renard, C., Geffrotin, C., Delanian, S., Lefaix, J.L., Martin, M. Free Radic. Biol. Med. (2001) [Pubmed]
  7. Localization of the tenascin-C gene to pig chromosome 1. Garrido, J.J., Lahbib-Mansais, Y., Geffrotin, C., Yerle, M., Vaiman, M. Mamm. Genome (1995) [Pubmed]
  8. The positive inotropic effect of pimobendan involves stereospecific increases in the calcium sensitivity of cardiac myofilaments. Solaro, R.J., Fujino, K., Sperelakis, N. J. Cardiovasc. Pharmacol. (1989) [Pubmed]
  9. Distinct tissue distribution in pigs of tenascin-X and tenascin-C transcripts. Geffrotin, C., Garrido, J.J., Tremet, L., Vaiman, M. Eur. J. Biochem. (1995) [Pubmed]
  10. The mechanism of in-stent restenosis in radius stent: an experimental porcine study. Iso, Y., Suzuki, H., Sato, T., Shoji, M., Shibata, M., Shimizu, N., Koba, S., Geshi, E., Katagiri, T. Circ. J. (2005) [Pubmed]
  11. Mesenchymal stem cell injection induces cardiac nerve sprouting and increased tenascin expression in a Swine model of myocardial infarction. Pak, H.N., Qayyum, M., Kim, D.T., Hamabe, A., Miyauchi, Y., Lill, M.C., Frantzen, M., Takizawa, K., Chen, L.S., Fishbein, M.C., Sharifi, B.G., Chen, P.S., Makkar, R. J. Cardiovasc. Electrophysiol. (2003) [Pubmed]
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