Disease relevance of MMP20

• Matrix metalloproteinase inhibition during the development of congestive heart failure : effects on left ventricular dimensions and function [1].
• Selective inhibition of matrix metalloproteinase isozymes and in vivo protection against emphysema by substituted gamma-keto carboxylic acids [2].
• Regulation of matrix metalloproteinase expression in endothelial cells by heat-inactivated Streptococcus pneumoniae [3].
• Myocardial and interstitial matrix metalloproteinase activity after acute myocardial infarction in pigs [4].
• Matrix metalloproteinase inhibition reduces intimal hyperplasia in a porcine arteriovenous-graft model [5].

High impact information on MMP20

• BACKGROUND: Inhibition of matrix metalloproteinase (MMP) activity after balloon angioplasty by intraperitoneal injection of batimastat reduces late lumen loss by inhibition of constrictive remodeling [6].
• Time-dependent changes in matrix metalloproteinase activity and expression during the progression of congestive heart failure: relation to ventricular and myocyte function [7].
• Cruciate ligament metabolism was determined by measuring the following markers of collagen turnover: matrix metalloproteinase 2 (MMP-2), tissue inhibitor of metalloproteinases 2, C-terminal type I procollagen propeptide (PICP), and the immature collagen-derived crosslink dihydroxylysinonorleucine (DHLNL) [8].
• Generation and novel distribution of matrix metalloproteinase-derived aggrecan fragments in porcine cartilage explants [9].
• The expansion was reduced significantly by the addition of either RU486 or Galardin, a broad-spectrum matrix metalloproteinase inhibitor [10].

Chemical compound and disease context of MMP20

• Marimastat inhibits elastin degradation and matrix metalloproteinase 2 activity in a model of aneurysm disease [11].
• We assessed cerebral injury in newborn piglets that underwent global hypoxia and subsequent resuscitation with 21 or 100% O2 by extracellular glycerol, matrix metalloproteinase (MMP) expression levels, and oxidative stress [12].
• Matrix metalloproteinase and elastase activities in LPS-induced acute lung injury in guinea pigs [13].

Biological context of MMP20

• A cDNA encoding a novel matrix metalloproteinase (MMP) was isolated from a porcine enamel organ-specific cDNA library [14].
• Molecular cloning and mRNA tissue distribution of a novel matrix metalloproteinase isolated from porcine enamel organ [14].
• PURPOSE: Trabecular meshwork (TM) matrix metalloproteinase (MMP), and tissue inhibitor (TIMP) changes in response to mechanical stretching appear to be central to intraocular pressure (IOP) homeostasis [15].
• Angiotensin-converting enzyme and matrix metalloproteinase inhibition with developing heart failure: comparative effects on left ventricular function and geometry [16].
• During this period of weaning anorexia, inflammatory T-cell numbers and local expression of the matrix metalloproteinase stromelysin increased while jejunal villus height, crypt depth and major histocompatibility complex (MHC) class I RNA expression decreased [17].

Anatomical context of MMP20

• In histiotypic culture on porous-polycarbonate membranes, porcine periodontal ligament epithelial cells responded to KGF with increased 92-kDa gelatinase (matrix metalloproteinase [MMP]-9) activity [18].
• The effect of bradykinin on the expression of some matrix metalloproteinase (MMP) genes was examined using isolated granulosa cells [19].
• The coronary arteries were either pressure-perfusion-fixed and prepared for histological examination, or dissected free of adventitia for further collagen and matrix metalloproteinase studies [20].
• Tenascin-C (TN-C) expression and matrix metalloproteinase (MMP) activity are induced within remodeling pulmonary arteries (PAs), where they promote cell growth [21].
• Enamelysin (MMP-20) is a tooth-specific matrix metalloproteinase that is initially expressed by ameloblasts and odontoblasts immediately prior to the onset of dentin mineralization, and continues to be expressed throughout the secretory stage of amelogenesis [22].

Associations of MMP20 with chemical compounds

• Tyrosine phosphatase inhibition induces loss of blood-brain barrier integrity by matrix metalloproteinase-dependent and -independent pathways [23].
• We examined the effects of graded reoxygenation on cardiac function, myocardial glutathione levels, and matrix metalloproteinase (MMP)-2 activity during recovery [24].
• ONO-4817, an orally active matrix metalloproteinase inhibitor, prevents lipopolysaccharide-induced proteoglycan release from the joint cartilage in guinea pigs [25].

Regulatory relationships of MMP20

• Six pigs were given an intra-articular injection of recombinant porcine interleukin-1beta (IL-1beta) into the knee joint before imaging to induce changes in cartilage via matrix metalloproteinase (MMP) induction [26].

Other interactions of MMP20

• Altered hemodynamics controls matrix metalloproteinase activity and tenascin-C expression in neonatal pig lung [21].
• Matrix metalloproteinase (MMP) gelatinase activity of bronchial lavage (BL) fluid from SM-exposed guinea pigs was high compared with controls, as shown by both zymography and biotinylated substrate degradation, whereas TIMP-1 and -2 levels by immunoblotting were similar [27].
• Bradykinin treatment induced MMP-3 and MMP-20 gene expression to an extreme degree [19].
• The tyrosine phosphatase inhibitor phenylarsine oxide (PAO) induced increased matrix metalloproteinase (MMP) activity, which was paralleled by severe disruption of cell-cell contacts and proteolysis of the tight junction protein occludin [23].
• OBJECTIVE: Matrix metalloproteinase (MMP)-9 plays an important role in neutrophil extravasation and migration by its ability to degrade the major components of basement membrane [28].

Analytical, diagnostic and therapeutic context of MMP20

• Oral matrix metalloproteinase inhibition and arterial remodeling after balloon dilation: an intravascular ultrasound study in the pig [6].
• The pulmonary injury was assessed by matrix metalloproteinase (MMP) activity, oxidative stress, IL-8, and histology 2.5 h after resuscitation from a hypoxic state [29].
• Matrix metalloproteinase inhibitor prevents acute lung injury after cardiopulmonary bypass [30].

References