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Gene Review

LIM2  -  lens intrinsic membrane protein 2, 19kDa

Homo sapiens

Synonyms: CTRCT19, Lens fiber membrane intrinsic protein, MP17, MP18, MP19, ...
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Disease relevance of LIM2


Psychiatry related information on LIM2


High impact information on LIM2

  • A missense mutation in the LIM2 gene is associated with autosomal recessive presenile cataract in an inbred Iraqi Jewish family [3].
  • Sequencing of LIM2, one of two candidate genes in this region, revealed a homozygous T-->G change resulting in a phenylalanine-to-valine substitution at position 105 of the protein [3].
  • Seven cysteinyl residues and a single histidyl residue in the LIM2 sequence, CX2CX17HX2CX2CX2CX17CX2C, comprise the conserved residues in the LIM consensus that are potential Zn(II) ligands [4].
  • Two Zn(II) binding sites exhibiting tetrathiolate (S4) and S3N1 Zn(II) coordination are displayed by LIM2 (Kosa, J. L., Michelsen, J. W., Louis, H. A., Olsen, J. I., Davis, D. R., Beckerle, M. C., and Winge, D. R. (1994) Biochemistry 33, 468-477) [4].
  • Site-directed mutagenesis was employed to generate three mutant LIM2 proteins with conversions of the second conserved cysteine to histidine (C2H), the fifth conserved cysteine to histidine (C5H), and the last conserved cysteine to aspartate (C8D) [4].

Biological context of LIM2

  • 4. The position of the LIM2 gene appears to be within 40 kb of the electron transport flavoprotein gene (ETFB) as a cosmid containing sequences from both genes has been identified [5].
  • Assignment of the human lens fiber cell MP19 gene (LIM2) to chromosome 19q13.4, and adjacent to ETFB [5].
  • Perturbation of LIM3 or 4 inhibited adhesion while mutation of LIM2 or 4 decreased cell motility [6].
  • Since the LIM2 gene promoter does not contain a classic TATA box, the Hsu element may serve as the site for binding the RNA polymerase complex [7].
  • Analyses of ESTs also reveal examples of alternative transcripts, including a major alternative splice form for the lens specific membrane protein MP19 [8].

Anatomical context of LIM2


Associations of LIM2 with chemical compounds

  • Binding between MP20 and galectin-3 was disrupted by lactose suggesting the lectin site was involved in the interaction [9].

Other interactions of LIM2

  • The discovery of an abundant, novel transcript, lengsin, and a major novel splice form of MP19 reflect the utility of unamplified libraries constructed from dissected tissue [8].

Analytical, diagnostic and therapeutic context of LIM2


  1. Suppression of FOXO1 activity by FHL2 through SIRT1-mediated deacetylation. Yang, Y., Hou, H., Haller, E.M., Nicosia, S.V., Bai, W. EMBO J. (2005) [Pubmed]
  2. Assignment of the lens intrinsic membrane protein MP19 structural gene to human chromosome 19. Church, R.L., Wang, J. Curr. Eye Res. (1992) [Pubmed]
  3. A missense mutation in the LIM2 gene is associated with autosomal recessive presenile cataract in an inbred Iraqi Jewish family. Pras, E., Levy-Nissenbaum, E., Bakhan, T., Lahat, H., Assia, E., Geffen-Carmi, N., Frydman, M., Goldman, B., Pras, E. Am. J. Hum. Genet. (2002) [Pubmed]
  4. Mutational analysis of the metal sites in an LIM domain. Michelsen, J.W., Sewell, A.K., Louis, H.A., Olsen, J.I., Davis, D.R., Winge, D.R., Beckerle, M.C. J. Biol. Chem. (1994) [Pubmed]
  5. Assignment of the human lens fiber cell MP19 gene (LIM2) to chromosome 19q13.4, and adjacent to ETFB. Lieuallen, K., Christensen, M., Brandriff, B., Church, R., Wang, J., Lennon, G. Somat. Cell Mol. Genet. (1994) [Pubmed]
  6. Roles for the tubulin- and PTP-PEST-binding paxillin LIM domains in cell adhesion and motility. Brown, M.C., Turner, C.E. Int. J. Biochem. Cell Biol. (2002) [Pubmed]
  7. Identification of a lens-specific cis-acting element within the basal promoter of the human lens intrinsic membrane protein MP19 gene (LIM2). Hsu, H., Zhang, S.R., Sang, J.L., Qi, R.M., Church, R.L. Sheng Wu Gong Cheng Xue Bao (2004) [Pubmed]
  8. Expressed sequence tag analysis of adult human lens for the NEIBank Project: over 2000 non-redundant transcripts, novel genes and splice variants. Wistow, G., Bernstein, S.L., Wyatt, M.K., Behal, A., Touchman, J.W., Bouffard, G., Smith, D., Peterson, K. Mol. Vis. (2002) [Pubmed]
  9. MP20, the second most abundant lens membrane protein and member of the tetraspanin superfamily, joins the list of ligands of galectin-3. Gonen, T., Grey, A.C., Jacobs, M.D., Donaldson, P.J., Kistler, J. BMC Cell Biol. (2001) [Pubmed]
  10. The human lens fiber-cell intrinsic membrane protein MP19 gene: isolation and sequence analysis. Church, R.L., Wang, J.H. Curr. Eye Res. (1993) [Pubmed]
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