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Chemical Compound Review

Ethynyl     ethyne

Synonyms: acetylenyl, HCC(.), CHEBI:30085, AC1L3W8F, C2H(.), ...
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Disease relevance of acetylene

  • BACKGROUND: Although hepatitis C virus (HCV) infection is recognized as an important risk factor for hepatocellular carcinoma HCC), the strength of this association has been inconsistent [1].
  • In FNH, Ang-1 was significantly up-regulated, Ang-2 was down-regulated, and the Ang-1/Ang-2 ratio was highly and specifically increased in FNH compared with normal liver or other groups of lesions (FNH, 15.2-fold increase; HCC, 2.78; adenoma, 2.28; cirrhosis, 1.92; P < 0.01 for FNH vs. all groups, analysis of variance) [2].
  • In myoma, alpha-naphthoflavone and a set of ethynyl polycyclic hydrocarbon inhibitors (5 microM) each inhibited 4-hydroxylation more efficiently (up to 90%) than 2-hydroxylation (up to 40%), indicating > 10-fold differences in Ki (<0.5 microM vs. > 5 microM) [3].
  • Important unanswered questions are, therefore: how often do "healthy" carriers develop cirrhosis and/or HCC, including the time relations between the two [4]?
  • Orthotopic liver transplantation (OLT) is the only curative therapy of HCC with underlying cirrhosis, but due to HCC metastasis and recurrence, its benefit is limited to a small population who meet the strict selection criteria [5].

Psychiatry related information on acetylene


High impact information on acetylene

  • Similarly, white blood cell ribonuclease activity was elevated in mice of the strains AKR, C2H/He, PL and RF [10].
  • In addition, the role of specific HCV genotypes in HCC progression has not yet been determined [1].
  • The differences between the two control groups and the ethynyl estradiol group were significant (P < 0.005) [11].
  • In looking for such a predisposition, we have compared the histocompatibility antigens (HLA) of 102 southern African blacks with histologically proved HCC with those of 208 healthy blacks [12].
  • The incidence of HCC following IFN treatment is dependent on the effect of IFN on ALT levels [13].

Chemical compound and disease context of acetylene

  • Antibacterial evaluation of compounds 2 with A = alkyl, ethenyl, ethynyl, hydroxyalkyl, aldo and keto, oximinoakyl, carboalkoxy, nitro, amino, halo and psi-halo, alkylthio, alkylsulfinyl, and alkysulfonyl against Staphylococcus aureus and Enterococcus faecalis led to the identification of several SAR trends [14].
  • Thus, SM3 may play an important role in the metastasis of HCC cells by causing the interaction of integrin alphaVbeta3 with vitronectin [15].
  • The kinetics of Zn(2+) binding by two point-mutated forms of the HIV-1 NCp7 C-terminal zinc finger, each containing tridentate binding motif HCC [Ser49(35-50)NCp7] or CCC [Ala44(35-50)NCp7], has been studied by stopped-flow spectrofluorimetry [16].
  • We herein report a case of HCC presenting with severe, uncontrollable hypoglycemia that was managed with percutaneous ethanol injection therapy [17].
  • RESULTS: The growth of ER+ T47D cells was sensitive to tamoxifen, ICI-182,780, and ethynyl estradiol (EE2), whereas another ER+ breast cancer cell line, 21 PT, was resistant to these compounds [18].

Biological context of acetylene

  • Although gene expression profiles in HCC derived in all three transgenic lines were highly similar, oncogene-specific gene expression signatures were identified at an early dysplastic stage of hepatocarcinogenesis [19].
  • Our studies with restriction fragment length polymorphisms support such a mechanism involving Chromosome 11 in HCC [20].
  • Moreover, the degree of reduced DNA methylation was related to late histopathological HCC grade (P = 0.005) and large tumor size (P = 0.079) [21].
  • Five weeks of oral dosing confirmed that ethynyl estradiol, tamoxifen, and raloxifene are potent inhibitors of the loss in volumetric bone mineral density (BMD, mg/cc) induced by ovariectomy, as measured by computed tomography [22].
  • Some hepatitis C virus (HCV) proteins, including core protein, deregulate the cell cycle of infected cells, thereby playing an important role in the viral pathogenesis of HCC [23].

Anatomical context of acetylene


Associations of acetylene with other chemical compounds


Gene context of acetylene

  • CONCLUSIONS: The results suggest that enhanced AAH gene activity is a common feature of human HCC and growth factor signaling through IRS-1 regulates AAH expression and increases motility and invasion of HCC cells [34].
  • MMP-9 activities of HFH-T2, HepG2-HBV and Hep3B were significantly higher than that of non-HBV-hepatocellular carcinoma SK-Hep1 and HepG2 (HCC origin, HBV not detected), as assayed by gelatin zymography [35].
  • There was no significant difference in mean VEGF expression between HCC tumor (1.06+/- 0.43) and adjacent tissue (0. 85+/-0.42) although the tumors tended to have higher expression than adjacent non-malignant tissues [36].
  • These results demonstrate that spontaneously developed HCC in AOX-/- mice display a similar type of pleiotropic responses to high levels of PPARalpha ligands as the non-neoplastic liver [37].
  • CCR6 expression in human HCC tissues was confirmed by RT-PCR [38].

Analytical, diagnostic and therapeutic context of acetylene

  • PURPOSE: We conducted a case-control study to estimate the relative risk (RR) of HCC in relation to HCV infection among residents of the Fukuoka Prefecture, where HCC risk is among the highest in Japan, and to examine whether the risk differs according to HCV genotypes and/or HCV RNA titers [1].
  • Expansion of criteria for liver transplantation in HCC: a slippery slope [39]?
  • Surveillance plus chemoprevention in cirrhotic patients with HCV: a better outlook for HCC [40]?
  • DCP levels greater than 0.1 AU/ml (100 ng/ml) on ELISA are highly suggestive of HCC or tumor recurrence [41].
  • Therefore, liver resection prior to transplantation can be integrated in the treatment strategy for HCC [42].


  1. Hepatitis C virus infection and risk of hepatocellular carcinoma among Japanese: possible role of type 1b (II) infection. Tanaka, K., Ikematsu, H., Hirohata, T., Kashiwagi, S. J. Natl. Cancer Inst. (1996) [Pubmed]
  2. A quantitative gene expression study suggests a role for angiopoietins in focal nodular hyperplasia. Paradis, V., Bièche, I., Dargère, D., Laurendeau, I., Nectoux, J., Degott, C., Belghiti, J., Vidaud, M., Bedossa, P. Gastroenterology (2003) [Pubmed]
  3. 4-Hydroxylation of estradiol by human uterine myometrium and myoma microsomes: implications for the mechanism of uterine tumorigenesis. Liehr, J.G., Ricci, M.J., Jefcoate, C.R., Hannigan, E.V., Hokanson, J.A., Zhu, B.T. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  4. Relation of the hepatitis B virus carrier state to hepatocellular carcinoma. Popper, H., Shafritz, D.A., Hoofnagle, J.H. Hepatology (1987) [Pubmed]
  5. A randomized controlled trial of Licartin for preventing hepatoma recurrence after liver transplantation. Xu, J., Shen, Z.Y., Chen, X.G., Zhang, Q., Bian, H.J., Zhu, P., Xu, H.Y., Song, F., Yang, X.M., Mi, L., Zhao, Q.C., Tian, R., Feng, Q., Zhang, S.H., Li, Y., Jiang, J.L., Li, L., Yu, X.L., Zhang, Z., Chen, Z.N. Hepatology (2007) [Pubmed]
  6. Hepatitis C virus infection is an additive risk factor for development of hepatocellular carcinoma in patients with cirrhosis. Caporaso, N., Romano, M., Marmo, R., de Sio, I., Morisco, F., Minerva, A., Coltorti, M. J. Hepatol. (1991) [Pubmed]
  7. Hepatitis C and alcohol. Degos, F. J. Hepatol. (1999) [Pubmed]
  8. The role of the habenular complex in the elevation of dorsal raphe nucleus serotonin and the changes in the behavioral responses produced by uncontrollable stress. Amat, J., Sparks, P.D., Matus-Amat, P., Griggs, J., Watkins, L.R., Maier, S.F. Brain Res. (2001) [Pubmed]
  9. Screening for cancer in viral hepatitis. Colombo, M. Clinics in liver disease. (2001) [Pubmed]
  10. Elevated ribonuclease activity in the thymus and white blood cells of genetically cancer prone mice. Drake, W.P., Pokorney, D.R., Chipman, S., Levy, C.C., Mardiney, M.R. J. Exp. Med. (1975) [Pubmed]
  11. Estrogen-induced zonal changes in rat liver sinusoids. Raufman, J.P., Miller, D.L., Gumucio, J.J. Gastroenterology (1980) [Pubmed]
  12. Histocompatibility antigens in patients with hepatocellular carcinoma and their relationship to chronic hepatitis B virus infection in these patients. Kew, M.C., Gear, A.J., Baumgarten, I., Dusheiko, G.M., Maier, G. Gastroenterology (1979) [Pubmed]
  13. Relationship between infection with hepatitis C virus and hepatocellular carcinoma in Japan. Iino, S. Antivir. Ther. (Lond.) (1998) [Pubmed]
  14. Antibacterials. Synthesis and structure-activity studies of 3-aryl-2-oxooxazolidines. 2. The "A" group. Gregory, W.A., Brittelli, D.R., Wang, C.L., Kezar, H.S., Carlson, R.K., Park, C.H., Corless, P.F., Miller, S.J., Rajagopalan, P., Wuonola, M.A. J. Med. Chem. (1990) [Pubmed]
  15. Lactosylsulfatide expression in hepatocellular carcinoma cells enhances cell adhesion to vitronectin and intrahepatic metastasis in nude mice. Zhong Wu, X., Honke, K., Long Zhang, Y., Liang Zha, X., Taniguchi, N. Int. J. Cancer (2004) [Pubmed]
  16. Mechanism of zinc coordination by point-mutated structures of the distal CCHC binding motif of the HIV-1 NCp7 protein. Bombarda, E., Roques, B.P., Mély, Y., Grell, E. Biochemistry (2005) [Pubmed]
  17. A case of hepatocellular carcinoma associated with troublesome hypoglycemia: management by cytoreduction using percutaneous ethanol injection. Saigal, S., Nandeesh, H.P., Malhotra, V., Sarin, S.K. Am. J. Gastroenterol. (1998) [Pubmed]
  18. Classification of breast cancer cells on the basis of a functional assay for estrogen receptor. Biswas, D.K., Averboukh, L., Sheng, S., Martin, K., Ewaniuk, D.S., Jawde, T.F., Wang, F., Pardee, A.B. Mol. Med. (1998) [Pubmed]
  19. Oncogene-specific gene expression signatures at preneoplastic stage in mice define distinct mechanisms of hepatocarcinogenesis. Coulouarn, C., Gomez-Quiroz, L.E., Lee, J.S., Kaposi-Novak, P., Conner, E.A., Goldina, T.A., Onishchenko, G.E., Factor, V.M., Thorgeirsson, S.S. Hepatology (2006) [Pubmed]
  20. Molecular aspects of persistent woodchuck hepatitis virus and hepatitis B virus infection and hepatocellular carcinoma. Rogler, C.E., Hino, O., Su, C.Y. Hepatology (1987) [Pubmed]
  21. Genome-wide hypomethylation in hepatocellular carcinogenesis. Lin, C.H., Hsieh, S.Y., Sheen, I.S., Lee, W.C., Chen, T.C., Shyu, W.C., Liaw, Y.F. Cancer Res. (2001) [Pubmed]
  22. Raloxifene, tamoxifen, nafoxidine, or estrogen effects on reproductive and nonreproductive tissues in ovariectomized rats. Sato, M., Rippy, M.K., Bryant, H.U. FASEB J. (1996) [Pubmed]
  23. Role of p38 MAPK and RNA-dependent Protein Kinase (PKR) in Hepatitis C Virus Core-dependent Nuclear Delocalization of Cyclin B1. Spaziani, A., Alisi, A., Sanna, D., Balsano, C. J. Biol. Chem. (2006) [Pubmed]
  24. Characteristics of a cell line (Tong/HCC) established from a human hepatocellular carcinoma. Stevenson, D., Lin, J.H., Tong, M.J., Marshall, G.J. Hepatology (1987) [Pubmed]
  25. An update on iron metabolism: summary of the Fifth International Conference on Disorders of Iron Metabolism. Bonkovsky, H.L., Ponka, P., Bacon, B.R., Drysdale, J., Grace, N.D., Tavill, A.S. Hepatology (1996) [Pubmed]
  26. Hepatobiliary carcinoma in primary sclerosing cholangitis: a case control study. Leidenius, M., Höckersted, K., Broomé, U., Ericzon, B.G., Friman, S., Olausson, M., Schrumpf, E. J. Hepatol. (2001) [Pubmed]
  27. T cell infiltration and prognosis in HCC patients. Parmiani, G., Anichini, A. J. Hepatol. (2006) [Pubmed]
  28. Suppression of hepatocellular carcinoma by transplantation of ex-vivo immune-modulated NKT lymphocytes. Margalit, M., Shibolet, O., Klein, A., Elinav, E., Alper, R., Thalenfeld, B., Engelhardt, D., Rabbani, E., Ilan, Y. Int. J. Cancer (2005) [Pubmed]
  29. Long-acting octreotide versus placebo for treatment of advanced HCC: A randomized controlled double-blind study. Becker, G., Allgaier, H.P., Olschewski, M., Z??hringer, A., Blum, H.E. Hepatology (2007) [Pubmed]
  30. Hydration of the RNA duplex r(CGCAAAUUUGCG)2 determined by NMR. Conte, M.R., Conn, G.L., Brown, T., Lane, A.N. Nucleic Acids Res. (1996) [Pubmed]
  31. Estradiol treatment of acromegaly. Reduction of immunoreactive somatomedin-C and improvement in metabolic status. Clemmons, D.R., Underwood, L.E., Ridgway, E.C., Kliman, B., Kjellberg, R.N., Van Wyk, J.J. Am. J. Med. (1980) [Pubmed]
  32. The metabolic oxidation of the ethynyl group in 4-ethynylbiphenyl in vitro. Wade, A., Symons, A.M., Martin, L., Parke, D.V. Biochem. J. (1980) [Pubmed]
  33. 6-Alkyl- and 6-arylandrost-4-ene-3,17-diones as aromatase inhibitors. Synthesis and structure-activity relationships. Numazawa, M., Oshibe, M. J. Med. Chem. (1994) [Pubmed]
  34. Aspartyl-(asparaginyl)-beta-hydroxylase regulates hepatocellular carcinoma invasiveness. Monte, S.M., Tamaki, S., Cantarini, M.C., Ince, N., Wiedmann, M., Carter, J.J., Lahousse, S.A., Califano, S., Maeda, T., Ueno, T., D'Errico, A., Trevisani, F., Wands, J.R. J. Hepatol. (2006) [Pubmed]
  35. Association of a high activity of matrix metalloproteinase-9 to low levels of tissue inhibitors of metalloproteinase-1 and -3 in human hepatitis B-viral hepatoma cells. Kim, J.R., Kim, C.H. Int. J. Biochem. Cell Biol. (2004) [Pubmed]
  36. Vascular endothelial growth factor/vascular permeability factor mRNA expression in patients with chronic hepatitis C and hepatocellular carcinoma. Shimoda, K., Mori, M., Shibuta, K., Banner, B.F., Barnard, G.F. Int. J. Oncol. (1999) [Pubmed]
  37. Expression of peroxisome proliferator-activated receptor alpha, and PPARalpha regulated genes in spontaneously developed hepatocellular carcinomas in fatty acyl-CoA oxidase null mice. Meyer, K., Jia, Y., Cao, W.Q., Kashireddy, P., Rao, M.S. Int. J. Oncol. (2002) [Pubmed]
  38. Chemokine CCL20 enhances the growth of HuH7 cells via phosphorylation of p44/42 MAPK in vitro. Fujii, H., Itoh, Y., Yamaguchi, K., Yamauchi, N., Harano, Y., Nakajima, T., Minami, M., Okanoue, T. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  39. Expansion of criteria for liver transplantation in HCC: a slippery slope? Eng, S.C., Kowdley, K.V. Gastroenterology (2002) [Pubmed]
  40. Surveillance plus chemoprevention in cirrhotic patients with HCV: a better outlook for HCC? Blendis, L. Gastroenterology (2004) [Pubmed]
  41. Des-gamma-carboxy (abnormal) prothrombin and hepatocellular carcinoma: a critical review. Weitz, I.C., Liebman, H.A. Hepatology (1993) [Pubmed]
  42. Resection prior to liver transplantation for hepatocellular carcinoma. Belghiti, J., Cortes, A., Abdalla, E.K., Régimbeau, J.M., Prakash, K., Durand, F., Sommacale, D., Dondero, F., Lesurtel, M., Sauvanet, A., Farges, O., Kianmanesh, R. Ann. Surg. (2003) [Pubmed]
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