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LRMP  -  lymphoid-restricted membrane protein

Homo sapiens

Synonyms: JAW1, Lymphoid-restricted membrane protein, Protein Jaw1
 
 
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Disease relevance of LRMP

  • A V141L polymorphism of the human LRMP gene is associated with survival of lung cancer patients [1].
  • In diffuse large B-cell lymphomas, Jaw1/LRMP was found in three-quarters (24/32) of the cases classified phenotypically as being of 'germinal centre' type, but it was also expressed in almost half (13/28) of the 'non-germinal centre' cases [2].
  • Peptide delivery mediated by Jaw1 to class I molecules was equal or better than that mediated by the adenovirus E3/19K glycoprotein signal sequence, and was sufficient to enable cytofluorographic detection of newly recruited thermostabile class I molecules at the surface of TAP-deficient cells [3].
  • Like Jaw1, which is down-regulated during lymphoid differentiation, Mrv1 is downregulated during monocytic differentiation of BXH2 leukemias [4].
 

High impact information on LRMP

  • Jaw1 is an endoplasmic reticulum (ER) resident protein representative of a class of proteins post translationally inserted into membranes via a type II membrane anchor (cytosolic NH2 domain, lumenal COOH domain) in a translocon-independent manner [3].
  • Deletion of the transmembrane region retargeted Jaw1 from the ER to the cytosol, and severely, although incompletely, abrogated its TAP-independent peptide carrier activity [3].
  • We found that Jaw1 can efficiently deliver a COOH-terminal antigenic peptide to class I molecules in transporter associated with antigen processing (TAP)-deficient cells or cells in which TAP is inactivated by the ICP47 protein [3].
  • In addition, the processing of the small lumenal domain of Jaw1 represents a novel post-translational protein modification performed by the endoplasmic reticulum [5].
  • By discontinuous sucrose gradient ultracentrifugation, differential sedimentation was noted for the four major Jaw1 protein isoforms, with two of the forms predominantly soluble and two microsome-bound [5].
 

Biological context of LRMP

 

Anatomical context of LRMP

  • Carboxyl-terminal targeting and novel post-translational processing of JAW1, a lymphoid protein of the endoplasmic reticulum [5].
  • Jaw1 is a novel lymphoid-restricted gene that is expressed in a developmentally regulated fashion in both the B and T cell lineages [6].
  • When overexpressed in HeLa cells, Jaw1 protein targeted to the ER [6].
  • Pre-T cell lines and normal mouse thymocytes express high levels of Jaw1 mRNA, whereas most mature T cell lines express low levels [6].
  • Jaw1 mRNA is abundantly expressed in pre-B and B cell lines with minimal or undetectable expression in plasma cell lines [6].
 

Other interactions of LRMP

  • These findings suggest that the LRMP V141L polymorphism can predict survival in lung ADCA and that the role of LRMP and CASC1 in human lung cancer risk may differ from that in mice [1].
  • Two amplified and overexpressed genes located on 12p11, KRAS2 and LRMP, were identified; these were validated with quantitative real-time PCR [7].
 

Analytical, diagnostic and therapeutic context of LRMP

References

  1. A V141L polymorphism of the human LRMP gene is associated with survival of lung cancer patients. Manenti, G., Galbiati, F., Pettinicchio, A., Spinola, M., Piconese, S., Leoni, V.P., Conti, B., Ravagnani, F., Incarbone, M., Pastorino, U., Dragani, T.A. Carcinogenesis (2006) [Pubmed]
  2. Jaw1/LRMP, a germinal centre-associated marker for the immunohistological study of B-cell lymphomas. Tedoldi, S., Paterson, J.C., Cordell, J., Tan, S.Y., Jones, M., Manek, S., Dei Tos, A.P., Roberton, H., Masir, N., Natkunam, Y., Pileri, S.A., Facchetti, F., Hansmann, M.L., Mason, D.Y., Marafioti, T. J. Pathol. (2006) [Pubmed]
  3. Two novel routes of transporter associated with antigen processing (TAP)-independent major histocompatibility complex class I antigen processing. Snyder, H.L., Bacík, I., Bennink, J.R., Kearns, G., Behrens, T.W., Bächi, T., Orlowski, M., Yewdell, J.W. J. Exp. Med. (1997) [Pubmed]
  4. Mrvi1, a common MRV integration site in BXH2 myeloid leukemias, encodes a protein with homology to a lymphoid-restricted membrane protein Jaw1. Shaughnessy, J.D., Largaespada, D.A., Tian, E., Fletcher, C.F., Cho, B.C., Vyas, P., Jenkins, N.A., Copeland, N.G. Oncogene (1999) [Pubmed]
  5. Carboxyl-terminal targeting and novel post-translational processing of JAW1, a lymphoid protein of the endoplasmic reticulum. Behrens, T.W., Kearns, G.M., Rivard, J.J., Bernstein, H.D., Yewdell, J.W., Staudt, L.M. J. Biol. Chem. (1996) [Pubmed]
  6. Jaw1, A lymphoid-restricted membrane protein localized to the endoplasmic reticulum. Behrens, T.W., Jagadeesh, J., Scherle, P., Kearns, G., Yewdell, J., Staudt, L.M. J. Immunol. (1994) [Pubmed]
  7. Identification of DNA copy number changes in microdissected serous ovarian cancer tissue using a cDNA microarray platform. Tsuda, H., Birrer, M.J., Ito, Y.M., Ohashi, Y., Lin, M., Lee, C., Wong, W.H., Rao, P.H., Lau, C.C., Berkowitz, R.S., Wong, K.K., Mok, S.C. Cancer Genet. Cytogenet. (2004) [Pubmed]
 
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