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Gene Review

Igfbp5  -  insulin-like growth factor binding protein 5

Mus musculus

Synonyms: AI256729, AW208790, IBP-5, IGF-binding protein 5, IGFBP-5, ...
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Disease relevance of Igfbp5


High impact information on Igfbp5


Chemical compound and disease context of Igfbp5

  • This accumulation of truncated IGFBP-5 in the conditioned medium was not dependent on osteoclastic bone resorption, since it was not blocked by calcitonin or a bisphosphonate which inhibited PTH- and PGE2-stimulated 45Ca-release [7].

Biological context of Igfbp5


Anatomical context of Igfbp5


Associations of Igfbp5 with chemical compounds


Physical interactions of Igfbp5


Regulatory relationships of Igfbp5


Other interactions of Igfbp5

  • Furthermore, as judged by in situ hybridization histochemistry, IGF-I appeared to increase both the number of IGFBP-5-expressing cells and the magnitude of their expression, an observation that was especially marked in the molecular layer and white matter of the cerebellum [12].
  • In the terminal end buds (TEBs), IGFBP-3 mRNA expression was consistent with its localization in the cap cells, whereas IGFBP-5 was highly expressed in the body cells of the TEB [23].
  • The refinement of the target region to four genes and the finding that the QTL affects IGFBP-5 levels suggest that PAPPA2 may be involved with normal postnatal growth [24].
  • Rapamycin which indirectly prevents activation of the p70 ribosomal protein-S6 kinase (p70S6k), suppressed IGFBP-5 induction [11].
  • 4. Zn(2+) is shown to depress the binding of both IGF-I and IGF-II to soluble secreted IGFBP-5; [(125)I]-IGF-I binding is affected more so than [(125)I]-IGF-II binding [14].

Analytical, diagnostic and therapeutic context of Igfbp5


  1. Insulin-like growth factor-binding protein-5 induces a gender-related decrease in bone mineral density in transgenic mice. Salih, D.A., Mohan, S., Kasukawa, Y., Tripathi, G., Lovett, F.A., Anderson, N.F., Carter, E.J., Wergedal, J.E., Baylink, D.J., Pell, J.M. Endocrinology (2005) [Pubmed]
  2. Structure of the IGF-binding domain of the insulin-like growth factor-binding protein-5 (IGFBP-5): implications for IGF and IGF-I receptor interactions. Kalus, W., Zweckstetter, M., Renner, C., Sanchez, Y., Georgescu, J., Grol, M., Demuth, D., Schumacher, R., Dony, C., Lang, K., Holak, T.A. EMBO J. (1998) [Pubmed]
  3. Androgen receptor up-regulates insulin-like growth factor binding protein-5 (IGFBP-5) expression in a human prostate cancer xenograft. Gregory, C.W., Kim, D., Ye, P., D'Ercole, A.J., Pretlow, T.G., Mohler, J.L., French, F.S. Endocrinology (1999) [Pubmed]
  4. Insulin-like growth factor-binding protein-5 inhibits the growth of human breast cancer cells in vitro and in vivo. Butt, A.J., Dickson, K.A., McDougall, F., Baxter, R.C. J. Biol. Chem. (2003) [Pubmed]
  5. Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3. Chapman, R.S., Lourenco, P.C., Tonner, E., Flint, D.J., Selbert, S., Takeda, K., Akira, S., Clarke, A.R., Watson, C.J. Genes Dev. (1999) [Pubmed]
  6. Insulin-like growth factor binding protein-5 modulates muscle differentiation through an insulin-like growth factor-dependent mechanism. James, P.L., Stewart, C.E., Rotwein, P. J. Cell Biol. (1996) [Pubmed]
  7. Intact insulin-like growth factor binding protein-5 (IGFBP-5) associates with bone matrix and the soluble fragments of IGFBP-5 accumulated in culture medium of neonatal mouse calvariae by parathyroid hormone and prostaglandin E2-treatment. Hakeda, Y., Kawaguchi, H., Hurley, M., Pilbeam, C.C., Abreu, C., Linkhart, T.A., Mohan, S., Kumegawa, M., Raisz, L.G. J. Cell. Physiol. (1996) [Pubmed]
  8. Insulin-like growth factor-binding protein 5 (Igfbp5) compromises survival, growth, muscle development, and fertility in mice. Salih, D.A., Tripathi, G., Holding, C., Szestak, T.A., Gonzalez, M.I., Carter, E.J., Cobb, L.J., Eisemann, J.E., Pell, J.M. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  9. Segmental Igfbp5 expression is specifically associated with the bent structure of zigzag hairs. Schlake, T. Mech. Dev. (2005) [Pubmed]
  10. Partitioning of IGFBP-5 actions in myogenesis: IGF-independent anti-apoptotic function. Cobb, L.J., Salih, D.A., Gonzalez, I., Tripathi, G., Carter, E.J., Lovett, F., Holding, C., Pell, J.M. J. Cell. Sci. (2004) [Pubmed]
  11. Up-regulation of insulin-like growth factor binding protein-5 is independent of muscle cell differentiation, sensitive to rapamycin, but insensitive to wortmannin and LY294002. Rousse, S., Montarras, D., Pinset, C., Dubois, C. Endocrinology (1998) [Pubmed]
  12. Insulin-like growth factor I (IGF-I) regulates IGF binding protein-5 gene expression in the brain. Ye, P., D'Ercole, J. Endocrinology (1998) [Pubmed]
  13. Castration-induced apoptosis of androgen-dependent shionogi carcinoma is associated with increased expression of genes encoding insulin-like growth factor-binding proteins. Nickerson, T., Miyake, H., Gleave, M.E., Pollak, M. Cancer Res. (1999) [Pubmed]
  14. Zinc partitions insulin-like growth factors (IGFs) from soluble IGF binding protein (IGFBP)-5 to the cell surface receptors of BC3H-1 muscle cells. McCusker, R.H., Novakofski, J. J. Cell. Physiol. (2003) [Pubmed]
  15. Role for cyclic adenosine monophosphate in modulating insulin-like growth factor binding protein secretion by muscle cells. McCusker, R.H., Clemmons, D.R. J. Cell. Physiol. (1998) [Pubmed]
  16. cDNA microarrays detect activation of a myogenic transcription program by the PAX3-FKHR fusion oncogene. Khan, J., Bittner, M.L., Saal, L.H., Teichmann, U., Azorsa, D.O., Gooden, G.C., Pavan, W.J., Trent, J.M., Meltzer, P.S. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  17. Zinc partitions IGFs from soluble IGF binding proteins (IGFBP)-5, but not soluble IGFBP-4, to myoblast IGF type 1 receptors. McCusker, R.H., Novakofski, J. J. Endocrinol. (2004) [Pubmed]
  18. Insulin-like growth factor binding proteins: IGF-dependent and -independent effects in the mammary gland. Flint, D.J., Tonner, E., Allan, G.J. Journal of mammary gland biology and neoplasia. (2000) [Pubmed]
  19. Comparison studies of IGFBP-5 binding to osteoblasts and osteoblast-derived extracellular matrix. Andress, D.L. Prog. Growth Factor Res. (1995) [Pubmed]
  20. Transforming growth factor-beta inhibition of insulin-like growth factor-binding protein-5 synthesis in skeletal muscle cells involves a c-Jun N-terminal kinase-dependent pathway. Rousse, S., Lallemand, F., Montarras, D., Pinset, C., Mazars, A., Prunier, C., Atfi, A., Dubois, C. J. Biol. Chem. (2001) [Pubmed]
  21. Prolactin inhibits cell loss and decreases matrix metalloproteinase expression in the involuting mouse mammary gland but fails to prevent cell loss in the mammary glands of mice expressing IGFBP-5 as a mammary transgene. Flint, D.J., Boutinaud, M., Whitelaw, C.B., Allan, G.J., Kolb, A.F. J. Mol. Endocrinol. (2006) [Pubmed]
  22. Transcriptional effects of chronic Akt activation in the heart. Cook, S.A., Matsui, T., Li, L., Rosenzweig, A. J. Biol. Chem. (2002) [Pubmed]
  23. Expression of the insulin-like growth factor binding proteins during postnatal development of the murine mammary gland. Allar, M.A., Wood, T.L. Endocrinology (2004) [Pubmed]
  24. PAPPA2, an enzyme that cleaves an insulin-like growth-factor-binding protein, is a candidate gene for a quantitative trait locus affecting body size in mice. Christians, J.K., Hoeflich, A., Keightley, P.D. Genetics (2006) [Pubmed]
  25. Mapping quantitative trait loci that influence serum insulin-like growth factor binding protein-5 levels in F2 mice (MRL/MpJ X SJL/J). Mohan, S., Masinde, G., Li, X., Baylink, D.J. Endocrinology (2003) [Pubmed]
  26. Human osteoblast-derived insulin-like growth factor (IGF) binding protein-5 stimulates osteoblast mitogenesis and potentiates IGF action. Andress, D.L., Birnbaum, R.S. J. Biol. Chem. (1992) [Pubmed]
  27. PTEN overexpression suppresses proliferation and differentiation and enhances apoptosis of the mouse mammary epithelium. Dupont, J., Renou, J.P., Shani, M., Hennighausen, L., LeRoith, D. J. Clin. Invest. (2002) [Pubmed]
  28. Heparin modulates the binding of insulin-like growth factor (IGF) binding protein-5 to a membrane protein in osteoblastic cells. Andress, D.L. J. Biol. Chem. (1995) [Pubmed]
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