The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

IGFBP4  -  insulin-like growth factor binding protein 4

Bos taurus

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of IGFBP4

  • IGFBP-4 was the predominant IGFBP expressed by both cell types and did not change with exposure to hypoxia [1].

High impact information on IGFBP4

  • The PCR-derived probe for IGFBP4 was used to screen a bovine pulmonary artery cDNA library for a full-length bovine IGFBP4 cDNA clone [2].
  • Thus, cultured bovine endothelial cells synthesize and secrete IGFBP2, IGFBP3, and IGFBP4 and have mRNA encoding IGFBP2-6 [2].
  • IGFBP4 protein was purified from bovine pulmonary artery-conditioned medium, shown to have N-terminal amino acid sequence DEAIHCPPCSEEKLARCR (identical to human IGFBP4) and to be secreted in glycosylated and nonglycosylated forms [2].
  • This clone contained an open reading frame encoding a 258-amino acid protein that was 97% identical to human IGFBP4, 268 basepairs of 5'-untranslated region, and a longer 1044 basepairs of 3'-untranslated region [2].
  • Differences between F1 and F2-F4 in diameter, estradiol, free IGF-I, and IGFBP-4 and -5 proteolytic activity were even greater in group 3 [3].

Biological context of IGFBP4


Anatomical context of IGFBP4


Associations of IGFBP4 with chemical compounds

  • Concentrations of P4 were correlated positively (r > 0.4; P < 0.05) with IGFBP-4 and -5 [11].
  • Heparin-binding peptides derived from the C-terminal domain of IGFBP-3 or -5 inhibited IGFBP-4 degradation [6].
  • The amount of 28-29-kDa IGFBPs (small form of IGFBP-5 and [or] glycosylated form of IGFBP-4) was inversely associated with concentrations of androstenedione [12].
  • Both IGFBP-2 and IGFBP-4 mRNA levels were consistently reduced in stretched cells but remained comparable to those of the control cells when the angiotensin II transducing pathway was blocked by inhibitors prior to the application of mechanical strain [13].
  • IGF-I (1 nM) enhanced release of IGFBP-3 while dexamethasone (1 nM) diminished release of IGFBP-4 [14].

Regulatory relationships of IGFBP4


Other interactions of IGFBP4

  • The expression of three genes (IGF2R, IGFBP-4, and IGF2) in some tissues showed significant differences between AF cell-derived and FF cell-derived clones [15].
  • In ligand blots IGFBP-3 and IGFBP-4 appeared as the most prominent species [14].
  • Other heparin-binding peptides derived from CTGF, HIP, and vitronectin also inhibited IGFBP-4 degradation, except in porcine follicles [6].
  • In contrast, insulin or glucagon alone had no effect on production of the IGFBP-4 by thecal cells but when combined inhibited IGFBP-4 production [10].
  • The four largest follicles (F1-F4) were dissected and concentrations of steroids, IGFBPs and free IGF-I and levels of proteolytic activity for IGFBP-4 and -5 in the follicular fluid were determined [3].

Analytical, diagnostic and therapeutic context of IGFBP4


  1. Modulation of insulin-like growth factor (IGF) and IGF binding protein biosynthesis by hypoxia in cultured vascular endothelial cells. Tucci, M., Nygard, K., Tanswell, B.V., Farber, H.W., Hill, D.J., Han, V.K. J. Endocrinol. (1998) [Pubmed]
  2. Endothelial cells express insulin-like growth factor-binding proteins 2 to 6. Moser, D.R., Lowe, W.L., Dake, B.L., Booth, B.A., Boes, M., Clemmons, D.R., Bar, R.S. Mol. Endocrinol. (1992) [Pubmed]
  3. Proteolysis of insulin-like growth factor binding proteins -4 and -5 in bovine follicular fluid: implications for ovarian follicular selection and dominance. Rivera, G.M., Fortune, J.E. Endocrinology (2003) [Pubmed]
  4. Apoptosis and autophagy in involuting bovine mammary gland is accompanied by up-regulation of TGF-beta1 and suppression of somatotropic pathway. Zarzyńska, J., Gajkowska, B., Wojewódzka, U., Dymnicki, E., Motyl, T. Polish journal of veterinary sciences (2007) [Pubmed]
  5. Insulin-like growth factor binding protein (IGFBP)4 accounts for the connective tissue distribution of endothelial cell IGFBPs perfused through the isolated heart. Boes, M., Booth, B.A., Sandra, A., Dake, B.L., Bergold, A., Bar, R.S. Endocrinology (1992) [Pubmed]
  6. Insulin-like growth factor (IGF)-binding protein-4 proteolytic degradation in bovine, equine, and porcine preovulatory follicles: regulation by IGFs and heparin-binding domain-containing peptides. Mazerbourg, S., Zapf, J., Bar, R.S., Brigstock, D.R., Monget, P. Biol. Reprod. (2000) [Pubmed]
  7. Gonadotrophin responsiveness, aromatase activity and insulin-like growth factor binding protein content of bovine ovarian follicles during the first follicular wave. Rhodes, F.M., Peterson, A.J., Jolly, P.D. Reproduction (2001) [Pubmed]
  8. Effect of negative energy balance on the insulin-like growth factor system in pre-recruitment ovarian follicles of post partum dairy cows. Llewellyn, S., Fitzpatrick, R., Kenny, D.A., Murphy, J.J., Scaramuzzi, R.J., Wathes, D.C. Reproduction (2007) [Pubmed]
  9. Alterations in follicular IGFBP mRNA expression and follicular fluid IGFBP concentrations during the first follicle wave in beef heifers. Canty, M.J., Boland, M.P., Evans, A.C., Crowe, M.A. Anim. Reprod. Sci. (2006) [Pubmed]
  10. Hormonal control of ovarian cell production of insulin-like growth factor binding proteins. Chamberlain, C.S., Spicer, L.J. Mol. Cell. Endocrinol. (2001) [Pubmed]
  11. Large variation in steroid concentrations and insulin-like growth factor binding proteins exists among individual small antral follicles collected from within cows at random stages of the estrous cycle. Roberts, A.J., Al-Hassan, M.J., Fricke, P.M., Echternkamp, S.E. J. Anim. Sci. (2006) [Pubmed]
  12. Insulin-like growth factor I and insulin-like growth factor-binding proteins in bovine serum and follicular fluid before and after the preovulatory surge of luteinizing hormone. Funston, R.N., Seidel, G.E., Klindt, J., Roberts, A.J. Biol. Reprod. (1996) [Pubmed]
  13. Mechanical regulation of IGF-I and IGF-binding protein gene transcription in bladder smooth muscle cells. Chaqour, B., Han, J.S., Tamura, I., Macarak, E. J. Cell. Biochem. (2002) [Pubmed]
  14. Production of insulin-like growth factor binding-proteins by bovine adrenomedullary cells: differential regulation by IGF-I and dexamethasone. Grønning, M., Serck-Hanssen, G. Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. (2003) [Pubmed]
  15. Expression of insulin-like growth factors systems in cloned cattle dead within hours after birth. Li, S., Li, Y., Yu, S., Du, W., Zhang, L., Dai, Y., Liu, Y., Li, N. Mol. Reprod. Dev. (2007) [Pubmed]
  16. Bovine oviductal and embryonic insulin-like growth factor binding proteins: possible regulators of "embryotrophic" insulin-like growth factor circuits. Winger, Q.A., de los Rios, P., Han, V.K., Armstrong, D.T., Hill, D.J., Watson, A.J. Biol. Reprod. (1997) [Pubmed]
  17. Fibronectin fragments upregulate insulin-like growth factor binding proteins in chondrocytes. Purple, C.R., Untermann, T.G., Pichika, R., Homandberg, G.A. Osteoarthr. Cartil. (2002) [Pubmed]
WikiGenes - Universities