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Gene Review

MAT1A  -  methionine adenosyltransferase I, alpha

Homo sapiens

Synonyms: AMS1, AdoMet synthase 1, MAT, MAT 1, MAT-I/III, ...
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Disease relevance of MAT1A


Psychiatry related information on MAT1A


High impact information on MAT1A

  • The levels of MAT1A mRNA as well as MAT I/III protein decreased in cultured rat hepatocytes by in situ generation of ceramide from exogenous human placenta ASMase [8].
  • Here we show that acidic sphingomyelinase (ASMase) mediates the downregulation of MAT1A by TNF-alpha [8].
  • Demyelination of the brain is associated with methionine adenosyltransferase I/III deficiency [9].
  • We recently demonstrated that apoptosis was prominent in undifferentiated cells around dysplastic tubules (Winyard, P.J.D., J. Nauta, D.S. Lirenman, P. Hardman, V.R. Sams, R.A. Risdon, and A.S. Woolf. 1996. Kidney Int. 49:135-146), perhaps explaining the tendency of some of these organs to regress [10].
  • We investigated sulfur and methyl group metabolism in a 31-yr-old man with partial hepatic methionine adenosyltransferase (MAT) deficiency [11].

Chemical compound and disease context of MAT1A


Biological context of MAT1A


Anatomical context of MAT1A


Associations of MAT1A with chemical compounds


Regulatory relationships of MAT1A


Other interactions of MAT1A


Analytical, diagnostic and therapeutic context of MAT1A


  1. Differential expression of methionine adenosyltransferase genes influences the rate of growth of human hepatocellular carcinoma cells. Cai, J., Mao, Z., Hwang, J.J., Lu, S.C. Cancer Res. (1998) [Pubmed]
  2. Reduced mRNA abundance of the main enzymes involved in methionine metabolism in human liver cirrhosis and hepatocellular carcinoma. Avila, M.A., Berasain, C., Torres, L., Martín-Duce, A., Corrales, F.J., Yang, H., Prieto, J., Lu, S.C., Caballería, J., Rodés, J., Mato, J.M. J. Hepatol. (2000) [Pubmed]
  3. Methionine adenosyltransferase I/III deficiency: novel mutations and clinical variations. Chamberlin, M.E., Ubagai, T., Mudd, S.H., Thomas, J., Pao, V.Y., Nguyen, T.K., Levy, H.L., Greene, C., Freehauf, C., Chou, J.Y. Am. J. Hum. Genet. (2000) [Pubmed]
  4. Liver-specific methionine adenosyltransferase MAT1A gene expression is associated with a specific pattern of promoter methylation and histone acetylation: implications for MAT1A silencing during transformation. Torres, L., Avila, M.A., Carretero, M.V., Latasa, M.U., Caballería, J., López-Rodas, G., Boukaba, A., Lu, S.C., Franco, L., Mato, J.M. FASEB J. (2000) [Pubmed]
  5. Role of methionine adenosyltransferase and S-adenosylmethionine in alcohol-associated liver cancer. Lu, S.C., Mato, J.M. Alcohol (2005) [Pubmed]
  6. Decreased methionine adenosyltransferase activity in erythrocytes of patients with dementia disorders. Gomes Trolin, C., Regland, B., Oreland, L. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. (1995) [Pubmed]
  7. Influence of vitamin B12 on brain methionine adenosyltransferase activity in senile dementia of the Alzheimer's type. Gomes-Trolin, C., Gottfries, C.G., Regland, B., Oreland, L. Journal of neural transmission (Vienna, Austria : 1996) (1996) [Pubmed]
  8. Acidic sphingomyelinase downregulates the liver-specific methionine adenosyltransferase 1A, contributing to tumor necrosis factor-induced lethal hepatitis. Marí, M., Colell, A., Morales, A., Pañeda, C., Varela-Nieto, I., García-Ruiz, C., Fernández-Checa, J.C. J. Clin. Invest. (2004) [Pubmed]
  9. Demyelination of the brain is associated with methionine adenosyltransferase I/III deficiency. Chamberlin, M.E., Ubagai, T., Mudd, S.H., Wilson, W.G., Leonard, J.V., Chou, J.Y. J. Clin. Invest. (1996) [Pubmed]
  10. The PAX2 tanscription factor is expressed in cystic and hyperproliferative dysplastic epithelia in human kidney malformations. Winyard, P.J., Risdon, R.A., Sams, V.R., Dressler, G.R., Woolf, A.S. J. Clin. Invest. (1996) [Pubmed]
  11. Transsulfuration in an adult with hepatic methionine adenosyltransferase deficiency. Gahl, W.A., Bernardini, I., Finkelstein, J.D., Tangerman, A., Martin, J.J., Blom, H.J., Mullen, K.D., Mudd, S.H. J. Clin. Invest. (1988) [Pubmed]
  12. Changes in S-adenosylmethionine synthetase in human liver cancer: molecular characterization and significance. Cai, J., Sun, W.M., Hwang, J.J., Stain, S.C., Lu, S.C. Hepatology (1996) [Pubmed]
  13. Impact of weekly treatment with ferrous sulfate on hemoglobin level, morbidity and nutritional status of anemic infants. Lima, A.C., Lima, M.C., Guerra, M.Q., Romani, S.A., Eickmann, S.H., Lira, P.I. Jornal de pediatria (2006) [Pubmed]
  14. Role of promoter methylation in increased methionine adenosyltransferase 2A expression in human liver cancer. Yang, H., Huang, Z.Z., Zeng, Z., Chen, C., Selby, R.R., Lu, S.C. Am. J. Physiol. Gastrointest. Liver Physiol. (2001) [Pubmed]
  15. Methionine adenosyltransferase I/III deficiency: two Korean compound heterozygous siblings with a novel mutation. Kim, S.Z., Santamaria, E., Jeong, T.E., Levy, H.L., Mato, J.M., Corrales, F.J., Mudd, S.H. J. Inherit. Metab. Dis. (2002) [Pubmed]
  16. Dominant inheritance of isolated hypermethioninemia is associated with a mutation in the human methionine adenosyltransferase 1A gene. Chamberlin, M.E., Ubagai, T., Mudd, S.H., Levy, H.L., Chou, J.Y. Am. J. Hum. Genet. (1997) [Pubmed]
  17. Cloning and functional characterization of the 5'-flanking region of human methionine adenosyltransferase 1A gene. Zeng, Z., Huang, Z.Z., Chen, C., Yang, H., Mao, Z., Lu, S.C. Biochem. J. (2000) [Pubmed]
  18. The role of c-Myb in the up-regulation of methionine adenosyltransferase 2A expression in activated Jurkat cells. Zeng, Z., Yang, H., Huang, Z.Z., Chen, C., Wang, J., Lu, S.C. Biochem. J. (2001) [Pubmed]
  19. Persistent hypermethioninaemia with dominant inheritance. Blom, H.J., Davidson, A.J., Finkelstein, J.D., Luder, A.S., Bernardini, I., Martin, J.J., Tangerman, A., Trijbels, J.M., Mudd, S.H., Goodman, S.I. J. Inherit. Metab. Dis. (1992) [Pubmed]
  20. Methioninemia and myopathy: a new disorder. Gaull, G.E., Bender, A.N., Vulovic, D., Tallan, H.H., Schaffner, F. Ann. Neurol. (1981) [Pubmed]
  21. Induction of human methionine adenosyltransferase 2A expression by tumor necrosis factor alpha. Role of NF-kappa B and AP-1. Yang, H., Sadda, M.R., Yu, V., Zeng, Y., Lee, T.D., Ou, X., Chen, L., Lu, S.C. J. Biol. Chem. (2003) [Pubmed]
  22. Biochemical basis for the dominant inheritance of hypermethioninemia associated with the R264H mutation of the MAT1A gene. A monomeric methionine adenosyltransferase with tripolyphosphatase activity. Pérez Mato, I., Sanchez del Pino, M.M., Chamberlin, M.E., Mudd, S.H., Mato, J.M., Corrales, F.J. J. Biol. Chem. (2001) [Pubmed]
  23. Oxidation of specific methionine and tryptophan residues of apolipoprotein A-I in hepatocarcinogenesis. Fernández-Irigoyen, J., Santamaría, E., Sesma, L., Muñoz, J., Riezu, J.I., Caballería, J., Lu, S.C., Prieto, J., Mato, J.M., Avila, M.A., Corrales, F.J. Proteomics (2005) [Pubmed]
  24. Regulation of the human MAT2B gene encoding the regulatory beta subunit of methionine adenosyltransferase, MAT II. LeGros, L., Halim, A.B., Chamberlin, M.E., Geller, A., Kotb, M. J. Biol. Chem. (2001) [Pubmed]
  25. Proteome analysis of human hepatocellular carcinoma tissues by two-dimensional difference gel electrophoresis and mass spectrometry. Liang, C.R., Leow, C.K., Neo, J.C., Tan, G.S., Lo, S.L., Lim, J.W., Seow, T.K., Lai, P.B., Chung, M.C. Proteomics (2005) [Pubmed]
  26. Molecular profiling of hepatocellular carcinoma in mice with a chronic deficiency of hepatic s-adenosylmethionine: relevance in human liver diseases. Santamaría, E., Muñoz, J., Fernandez-Irigoyen, J., Sesma, L., Mora, M.I., Berasain, C., Lu, S.C., Mato, J.M., Prieto, J., Avila, M.A., Corrales, F.J. J. Proteome Res. (2006) [Pubmed]
  27. Differential expression of the S-adenosyl-L-methionine synthase genes during pea development. Gómez-Gómez, L., Carrasco, P. Plant Physiol. (1998) [Pubmed]
  28. Identification and characterization of aspartate residues that play key roles in the allosteric regulation of a transcription factor: aspartate 274 is essential for inducer binding in lac repressor. Chang, W.I., Barrera, P., Matthews, K.S. Biochemistry (1994) [Pubmed]
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