The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

CCNA1  -  cyclin A1

Homo sapiens

Synonyms: CT146, Cyclin-A1
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of CCNA1


High impact information on CCNA1

  • Y88 phosphorylation does not prevent p27 binding to cyclin A/Cdk2 [6].
  • Cyclin A1 is expressed in mice exclusively in the germ cell lineage and is expressed in humans at highest levels in the testis and certain myeloid leukaemia cells [7].
  • Cyclin A1 is therefore essential for spermatocyte passage into the first meiotic division in male mice, a function that cannot be complemented by the concurrently expressed B-type cyclins [7].
  • Cyclin A1 is required for meiosis in the male mouse [7].
  • Prior to the onset of gastrulation, cyclin A1 protein is stable during interphase of the cell cycle [8].

Chemical compound and disease context of CCNA1


Biological context of CCNA1


Anatomical context of CCNA1


Associations of CCNA1 with chemical compounds


Physical interactions of CCNA1


Regulatory relationships of CCNA1

  • Cyclin A1 was highly expressed in aggressive tumors and was significantly correlated with VEGF expression in 96 patients with prostate cancer [9].
  • While butyrate alone increased p21Waf1/Cip1 expression and down-regulated cdk 6 and cyclin A, and combined exposure with 1,25-(OH)2D3 resulted in a synergistic enhancement of butyrate-induced changes, expressions did not change from control level after treatment with butyrate and ZK 191732 [19].
  • Cyclin A1 overexpression enhances S phase entry consistent with an oncogenic function [20].
  • Further studies using ligands selective for various retinoic acid receptors suggested that cyclin A1 expression is negatively regulated by activated RAR alpha [21].

Other interactions of CCNA1

  • We report that cyclin A1 could bind to important cell cycle regulators: the Rb family of proteins, the transcription factor E2F-1, and the p21 family of proteins [1].
  • Histone kinase activities of cyclin A1/Cdks and cyclin A2/Cdks were found to be elevated in tumors [4].
  • However, induced coexpression of cyclin A1, Rb and AR in DU-145 cells in the presence of R1881 greatly promoted VEGF promoter activity [9].
  • GAPDH and cyclin A1 expression levels were detected in 37 histologically classified testicular tissue specimens by one-line RT-PCR [22].
  • Moreover, renal carcinoma-derived mutant p53s were deficient in inducing cyclin A1 expression in p53-null cells [23].

Analytical, diagnostic and therapeutic context of CCNA1


  1. Functions of cyclin A1 in the cell cycle and its interactions with transcription factor E2F-1 and the Rb family of proteins. Yang, R., Müller, C., Huynh, V., Fung, Y.K., Yee, A.S., Koeffler, H.P. Mol. Cell. Biol. (1999) [Pubmed]
  2. Cyclin E is the only cyclin-dependent kinase 2-associated cyclin that predicts metastasis and survival in early stage non-small cell lung cancer. Müller-Tidow, C., Metzger, R., Kügler, K., Diederichs, S., Idos, G., Thomas, M., Dockhorn-Dworniczak, B., Schneider, P.M., Koeffler, H.P., Berdel, W.E., Serve, H. Cancer Res. (2001) [Pubmed]
  3. Characterization of a second human cyclin A that is highly expressed in testis and in several leukemic cell lines. Yang, R., Morosetti, R., Koeffler, H.P. Cancer Res. (1997) [Pubmed]
  4. Elevated levels and distinct patterns of expression of A-type cyclins and their associated cyclin-dependent kinases in male germ cell tumors. Liao, C., Li, S.Q., Wang, X., Muhlrad, S., Bjartell, A., Wolgemuth, D.J. Int. J. Cancer (2004) [Pubmed]
  5. Knockdown of MBP-1 in human prostate cancer cells delays cell cycle progression. Ghosh, A.K., Steele, R., Ray, R.B. J. Biol. Chem. (2006) [Pubmed]
  6. Cdk-Inhibitory Activity and Stability of p27(Kip1) Are Directly Regulated by Oncogenic Tyrosine Kinases. Grimmler, M., Wang, Y., Mund, T., Cilensek, Z., Keidel, E.M., Waddell, M.B., Jäkel, H., Kullmann, M., Kriwacki, R.W., Hengst, L. Cell (2007) [Pubmed]
  7. Cyclin A1 is required for meiosis in the male mouse. Liu, D., Matzuk, M.M., Sung, W.K., Guo, Q., Wang, P., Wolgemuth, D.J. Nat. Genet. (1998) [Pubmed]
  8. Identification of a developmental timer regulating the stability of embryonic cyclin A and a new somatic A-type cyclin at gastrulation. Howe, J.A., Howell, M., Hunt, T., Newport, J.W. Genes Dev. (1995) [Pubmed]
  9. A role for cyclin A1 in mediating the autocrine expression of vascular endothelial growth factor in prostate cancer. Wegiel, B., Bjartell, A., Ekberg, J., Gadaleanu, V., Brunhoff, C., Persson, J.L. Oncogene (2005) [Pubmed]
  10. Loss of cyclin A and G1-cell cycle arrest are a prerequisite of ceramide-induced toxicity in human arterial endothelial cells. Spyridopoulos, I., Mayer, P., Shook, K.S., Axel, D.I., Viebahn, R., Karsch, K.R. Cardiovasc. Res. (2001) [Pubmed]
  11. Protein kinase C beta1 is implicated in the regulation of neuroblastoma cell growth and proliferation. Svensson, K., Zeidman, R., Trollér, U., Schultz, A., Larsson, C. Cell Growth Differ. (2000) [Pubmed]
  12. A distinct cyclin A is expressed in germ cells in the mouse. Sweeney, C., Murphy, M., Kubelka, M., Ravnik, S.E., Hawkins, C.F., Wolgemuth, D.J., Carrington, M. Development (1996) [Pubmed]
  13. Cyclin A1 is predominantly expressed in hematological malignancies with myeloid differentiation. Krämer, A., Hochhaus, A., Saussele, S., Reichert, A., Willer, A., Hehlmann, R. Leukemia (1998) [Pubmed]
  14. Cyclin A1 directly interacts with B-myb and cyclin A1/cdk2 phosphorylate B-myb at functionally important serine and threonine residues: tissue-specific regulation of B-myb function. Müller-Tidow, C., Wang, W., Idos, G.E., Diederichs, S., Yang, R., Readhead, C., Berdel, W.E., Serve, H., Saville, M., Watson, R., Koeffler, H.P. Blood (2001) [Pubmed]
  15. Regulation of the cyclin A1 protein is associated with its differential subcellular localization in hematopoietic and leukemic cells. Ekberg, J., Landberg, G., Holm, C., Richter, J., Wolgemuth, D.J., Persson, J.L. Oncogene (2004) [Pubmed]
  16. Regulation of cell cycle progression and apoptosis by beta-carotene in undifferentiated and differentiated HL-60 leukemia cells: possible involvement of a redox mechanism. Palozza, P., Serini, S., Torsello, A., Boninsegna, A., Covacci, V., Maggiano, N., Ranelletti, F.O., Wolf, F.I., Calviello, G. Int. J. Cancer (2002) [Pubmed]
  17. Identification of interaction partners and substrates of the cyclin A1-CDK2 complex. Diederichs, S., Bäumer, N., Ji, P., Metzelder, S.K., Idos, G.E., Cauvet, T., Wang, W., Möller, M., Pierschalski, S., Gromoll, J., Schrader, M.G., Koeffler, H.P., Berdel, W.E., Serve, H., Müller-Tidow, C. J. Biol. Chem. (2004) [Pubmed]
  18. c-myb transactivates the human cyclin A1 promoter and induces cyclin A1 gene expression. Müller, C., Yang, R., Idos, G., Tidow, N., Diederichs, S., Koch, O.M., Verbeek, W., Bender, T.P., Koeffler, H.P. Blood (1999) [Pubmed]
  19. Short-chain fatty acids and colon cancer cells: the vitamin D receptor--butyrate connection. Gaschott, T., Stein, J. Recent Results Cancer Res. (2003) [Pubmed]
  20. Cyclin A1, the alternative A-type cyclin, contributes to G1/S cell cycle progression in somatic cells. Ji, P., Agrawal, S., Diederichs, S., Bäumer, N., Becker, A., Cauvet, T., Kowski, S., Beger, C., Welte, K., Berdel, W.E., Serve, H., Müller-Tidow, C. Oncogene (2005) [Pubmed]
  21. The aberrant fusion proteins PML-RAR alpha and PLZF-RAR alpha contribute to the overexpression of cyclin A1 in acute promyelocytic leukemia. Müller, C., Yang, R., Park, D.J., Serve, H., Berdel, W.E., Koeffler, H.P. Blood (2000) [Pubmed]
  22. Quantification of cyclin A1 and glyceraldehyde-3-phosphate dehydrogenase expression in testicular biopsies of infertile patients by fluorescence real-time RT-PCR. Schrader, M., Ravnik, S., Müller-Tidow, C., Müller, M., Straub, B., Diedrichs, S., Serve, H., Miller, K. Int. J. Androl. (2002) [Pubmed]
  23. Cyclin A1 is a p53-induced gene that mediates apoptosis, G2/M arrest, and mitotic catastrophe in renal, ovarian, and lung carcinoma cells. Rivera, A., Mavila, A., Bayless, K.J., Davis, G.E., Maxwell, S.A. Cell. Mol. Life Sci. (2006) [Pubmed]
  24. Expression of cyclin A1 and cell cycle proteins in hematopoietic cells and acute myeloid leukemia and links to patient outcome. Ekberg, J., Holm, C., Jalili, S., Richter, J., Anagnostaki, L., Landberg, G., Persson, J.L. Eur. J. Haematol. (2005) [Pubmed]
  25. Prognostic significance of cyclin A in gastric cancer. Mrena, J., Wiksten, J.P., Kokkola, A., Nordling, S., Haglund, C., Ristimäki, A. Int. J. Cancer (2006) [Pubmed]
WikiGenes - Universities