The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

HP1c  -  Heterochromatin Protein 1c

Drosophila melanogaster

Synonyms: CG6990, Dmel\CG6990, HP1, HP1C, Hp1c, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on HP1c


Biological context of HP1c


Anatomical context of HP1c


Associations of HP1c with chemical compounds

  • In this study, we show that a reduction in the levels of the JIL-1 histone H3S10 kinase results in the spreading of the major heterochromatin markers dimethyl H3K9 and HP1 to ectopic locations on the chromosome arms, with the most pronounced increase on the X chromosomes [10].

Other interactions of HP1c


Analytical, diagnostic and therapeutic context of HP1c


  1. JAK signaling globally counteracts heterochromatic gene silencing. Shi, S., Calhoun, H.C., Xia, F., Li, J., Le, L., Li, W.X. Nat. Genet. (2006) [Pubmed]
  2. Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain. Bannister, A.J., Zegerman, P., Partridge, J.F., Miska, E.A., Thomas, J.O., Allshire, R.C., Kouzarides, T. Nature (2001) [Pubmed]
  3. The role of histone H2Av variant replacement and histone H4 acetylation in the establishment of Drosophila heterochromatin. Swaminathan, J., Baxter, E.M., Corces, V.G. Genes Dev. (2005) [Pubmed]
  4. Drosophila atm/telomere fusion is required for telomeric localization of HP1 and telomere position effect. Oikemus, S.R., McGinnis, N., Queiroz-Machado, J., Tukachinsky, H., Takada, S., Sunkel, C.E., Brodsky, M.H. Genes Dev. (2004) [Pubmed]
  5. The hinge and chromo shadow domain impart distinct targeting of HP1-like proteins. Smothers, J.F., Henikoff, S. Mol. Cell. Biol. (2001) [Pubmed]
  6. Central role of Drosophila SU(VAR)3-9 in histone H3-K9 methylation and heterochromatic gene silencing. Schotta, G., Ebert, A., Krauss, V., Fischer, A., Hoffmann, J., Rea, S., Jenuwein, T., Dorn, R., Reuter, G. EMBO J. (2002) [Pubmed]
  7. Novel Drosophila heterochromatin protein 1 (HP1)/origin recognition complex-associated protein (HOAP) repeat motif in HP1/HOAP interactions and chromocenter associations. Badugu, R., Shareef, M.M., Kellum, R. J. Biol. Chem. (2003) [Pubmed]
  8. Heterochromatin protein 1 distribution during development and during the cell cycle in Drosophila embryos. Kellum, R., Raff, J.W., Alberts, B.M. J. Cell. Sci. (1995) [Pubmed]
  9. Distribution patterns of HP1, a heterochromatin-associated nonhistone chromosomal protein of Drosophila. James, T.C., Eissenberg, J.C., Craig, C., Dietrich, V., Hobson, A., Elgin, S.C. Eur. J. Cell Biol. (1989) [Pubmed]
  10. The JIL-1 histone H3S10 kinase regulates dimethyl H3K9 modifications and heterochromatic spreading in Drosophila. Zhang, W., Deng, H., Bao, X., Lerach, S., Girton, J., Johansen, J., Johansen, K.M. Development (2006) [Pubmed]
  11. Distinct HP1 and Su(var)3-9 complexes bind to sets of developmentally coexpressed genes depending on chromosomal location. Greil, F., van der Kraan, I., Delrow, J., Smothers, J.F., de Wit, E., Bussemaker, H.J., van Driel, R., Henikoff, S., van Steensel, B. Genes Dev. (2003) [Pubmed]
  12. Mechanisms of HP1-mediated gene silencing in Drosophila. Danzer, J.R., Wallrath, L.L. Development (2004) [Pubmed]
WikiGenes - Universities