The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

FLT1  -  fms-related tyrosine kinase 1

Bos taurus

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of LOC503620


High impact information on LOC503620


Biological context of LOC503620


Anatomical context of LOC503620

  • Characterization of VEGF receptor (VEGFR) expression revealed that BME, BAE, and BLE cell lines express VEGFR-1 and -2, whereas of the three cell lines assessed, only BAE cells express VEGFR-3 [7].

Associations of LOC503620 with chemical compounds


Physical interactions of LOC503620


Regulatory relationships of LOC503620


Other interactions of LOC503620

  • These results indicated that inhibition of VEGF interaction with VEGF receptor 2 is the mechanism serves A. cinnamomea as a protective mechanism composing the anti-angiogenesis function [14].
  • VEGF and VEGF receptor transcripts were analyzed by reverse transcription-polymerase chain reaction (RT-PCR) and ribonuclease protection assay [5].


  1. Comparative analysis of vascular endothelial growth factor receptors on retinal and aortic vascular endothelial cells. Thieme, H., Aiello, L.P., Takagi, H., Ferrara, N., King, G.L. Diabetes (1995) [Pubmed]
  2. Transforming growth factor beta1 induction of vascular endothelial growth factor receptor 1: mechanism of pericyte-induced vascular survival in vivo. Shih, S.C., Ju, M., Liu, N., Mo, J.R., Ney, J.J., Smith, L.E. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  3. VEGF receptor 2 and the adherens junction as a mechanical transducer in vascular endothelial cells. Shay-Salit, A., Shushy, M., Wolfovitz, E., Yahav, H., Breviario, F., Dejana, E., Resnick, N. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  4. Tyrosine phosphorylation of the vascular endothelial-growth-factor receptor-2 (VEGFR-2) is modulated by Rho proteins. Gingras, D., Lamy, S., Béliveau, R. Biochem. J. (2000) [Pubmed]
  5. Expression and tissue concentration of vascular endothelial growth factor, its receptors, and localization in the bovine corpus luteum during estrous cycle and pregnancy. Berisha, B., Schams, D., Kosmann, M., Amselgruber, W., Einspanier, R. Biol. Reprod. (2000) [Pubmed]
  6. Thioredoxin reductase regulates angiogenesis by increasing endothelial cell-derived vascular endothelial growth factor. Streicher, K.L., Sylte, M.J., Johnson, S.E., Sordillo, L.M. Nutrition and cancer. (2004) [Pubmed]
  7. Vascular endothelial growth factor (VEGF)-C synergizes with basic fibroblast growth factor and VEGF in the induction of angiogenesis in vitro and alters endothelial cell extracellular proteolytic activity. Pepper, M.S., Mandriota, S.J., Jeltsch, M., Kumar, V., Alitalo, K. J. Cell. Physiol. (1998) [Pubmed]
  8. Angiotensin II potentiates vascular endothelial growth factor-induced angiogenic activity in retinal microcapillary endothelial cells. Otani, A., Takagi, H., Suzuma, K., Honda, Y. Circ. Res. (1998) [Pubmed]
  9. Tranilast inhibits protein kinase C-dependent signalling pathway linked to angiogenic activities and gene expression of retinal microcapillary endothelial cells. Koyama, S., Takagi, H., Otani, A., Suzuma, K., Nishimura, K., Honda, Y. Br. J. Pharmacol. (1999) [Pubmed]
  10. Identification of a heparin binding peptide on the extracellular domain of the KDR VEGF receptor. Dougher, A.M., Wasserstrom, H., Torley, L., Shridaran, L., Westdock, P., Hileman, R.E., Fromm, J.R., Anderberg, R., Lyman, S., Linhardt, R.J., Kaplan, J., Terman, B.I. Growth Factors (1997) [Pubmed]
  11. Fibrinogen stimulates in vitro angiogenesis by choroidal endothelial cells via autocrine VEGF. Shiose, S., Hata, Y., Noda, Y., Sassa, Y., Takeda, A., Yoshikawa, H., Fujisawa, K., Kubota, T., Ishibashi, T. Graefes Arch. Clin. Exp. Ophthalmol. (2004) [Pubmed]
  12. Hypoxia regulates vascular endothelial growth factor receptor KDR/Flk gene expression through adenosine A2 receptors in retinal capillary endothelial cells. Takagi, H., King, G.L., Ferrara, N., Aiello, L.P. Invest. Ophthalmol. Vis. Sci. (1996) [Pubmed]
  13. Basic fibroblast growth factor induces expression of VEGF receptor KDR through a protein kinase C and p44/p42 mitogen-activated protein kinase-dependent pathway. Hata, Y., Rook, S.L., Aiello, L.P. Diabetes (1999) [Pubmed]
  14. Study for anti-angiogenic activities of polysaccharides isolated from Antrodia cinnamomea in endothelial cells. Cheng, J.J., Huang, N.K., Chang, T.T., Wang, D.L., Lu, M.K. Life Sci. (2005) [Pubmed]
WikiGenes - Universities