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GLTP  -  glycolipid transfer protein

Homo sapiens

Synonyms: Glycolipid transfer protein
 
 
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Disease relevance of GLTP

 

High impact information on GLTP

  • They included the use of glass-immobilized, glycolipid films to load GLTP with glycolipid and separation of GLTP/glycolipid complexes from vesicles containing glycolipid (galactosylceramide or lactosylceramide) or from monosialoganglioside dispersions by employing nickel-nitrilotriacetic acid-based affinity or gel filtration strategies [2].
  • In the present study, we have evaluated the functional consequences of point mutation of the glycolipid liganding site of human GLTP within the context of a carrier-based mechanism of glycolipid intermembrane transfer [2].
  • Recent structural determinations of the apo- and glycolipid-liganded forms of human GLTP have provided the first insights into the molecular architecture of the protein and its glycolipid binding site (Malinina, L., Malakhova, M. L., Brown, R. E., and Patel, D. J. (2004) Nature 430, 1048-1053) [2].
  • Also noteworthy was the inefficient release of glycolipid by wtGLTP into phosphatidylcholine acceptor vesicles, raising the possibility of a function other than intermembrane glycolipid transfer in vivo [2].
  • The cDNA open reading frame for porcine GLTP was constructed by reverse transcriptase-PCR [3].
 

Biological context of GLTP

  • A model of GLTP interaction with the membrane, based on the partitioning equilibrium data and consistent with the kinetics of GSL transfer, is presented and solved mathematically [4].
  • In this study, GLTP partitioning to membranes was analyzed by monitoring the fluorescence resonance energy transfer from tryptophans and tyrosines of GLTP to N-(5-dimethyl-aminonaphthalene-1-sulfonyl)-1,2-dihexadecanoyl-sn-glycero-3-phospho-ethanolamine present in bilayer vesicles [4].
  • The amino acid sequence of a glycolipid transfer protein from pig brain was determined by automatic sequencing and fast atom bombardment mass spectroscopic analysis of peptides produced by chemical and enzymatic cleavage reactions [5].
  • Furthermore, based on the structural comparison of the GLTP structures and the three-dimensional models of the related Podospora anserina HET-C2 and Arabidopsis thaliana accelerated cell death protein, ACD11, we give structural explanations for their specific lipid binding properties [6].
 

Anatomical context of GLTP

  • Because surface processes leading to the GLTP-GSL complex formation were limiting for GLTP action with SUVs and LUVs, it was concluded that GLTP is likely to be a valuable tool to probe and manipulate GSL environments in membranes [7].
  • Due to its capacity to bind certain types of gangliosides, SGP-1 appears to act as glycolipid transfer between Sertoli cells and the developing spermatids [8].
 

Associations of GLTP with chemical compounds

 

Other interactions of GLTP

 

Analytical, diagnostic and therapeutic context of GLTP

References

  1. Transfer of glycolipid between membranes of tissue culture cells, using dansylcerebroside as a model. Huang, R.T. Z. Naturforsch., C, Biosci. (1977) [Pubmed]
  2. Point mutational analysis of the liganding site in human glycolipid transfer protein. Functionality of the complex. Malakhova, M.L., Malinina, L., Pike, H.M., Kanack, A.T., Patel, D.J., Brown, R.E. J. Biol. Chem. (2005) [Pubmed]
  3. Cloning and expression of glycolipid transfer protein from bovine and porcine brain. Lin, X., Mattjus, P., Pike, H.M., Windebank, A.J., Brown, R.E. J. Biol. Chem. (2000) [Pubmed]
  4. Glycolipid transfer protein interaction with bilayer vesicles: modulation by changing lipid composition. Rao, C.S., Chung, T., Pike, H.M., Brown, R.E. Biophys. J. (2005) [Pubmed]
  5. Primary structure of glycolipid transfer protein from pig brain. Abe, A. J. Biol. Chem. (1990) [Pubmed]
  6. Structural evidence for adaptive ligand binding of glycolipid transfer protein. Airenne, T.T., Kidron, H., Nymalm, Y., Nylund, M., West, G., Mattjus, P., Salminen, T.A. J. Mol. Biol. (2006) [Pubmed]
  7. Glycolipid transfer protein mediated transfer of glycosphingolipids between membranes: a model for action based on kinetic and thermodynamic analyses. Rao, C.S., Lin, X., Pike, H.M., Molotkovsky, J.G., Brown, R.E. Biochemistry (2004) [Pubmed]
  8. Molecular role of sulfated glycoprotein-1 (SGP-1/prosaposin) in Sertoli cells. Morales, C.R., el-Alfy, M., Zhao, Q., Igdoura, S. Histol. Histopathol. (1995) [Pubmed]
  9. Human glycolipid transfer protein: probing conformation using fluorescence spectroscopy. Li, X.M., Malakhova, M.L., Lin, X., Pike, H.M., Chung, T., Molotkovsky, J.G., Brown, R.E. Biochemistry (2004) [Pubmed]
  10. Glycolipid-binding proteins. Sasaki, T. Chem. Phys. Lipids (1985) [Pubmed]
  11. Charged membrane surfaces impede the protein-mediated transfer of glycosphingolipids between phospholipid bilayers. Mattjus, P., Pike, H.M., Molotkovsky, J.G., Brown, R.E. Biochemistry (2000) [Pubmed]
  12. Glycolipid transfer protein and intracellular traffic of glucosylceramide. Sasaki, T. Experientia (1990) [Pubmed]
  13. Crystallization and X-ray analysis of bovine glycolipid transfer protein. West, G., Nymalm, Y., Airenne, T.T., Kidron, H., Mattjus, P., Salminen, T.T. Acta Crystallogr. D Biol. Crystallogr. (2004) [Pubmed]
 
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