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MeSH Review

Podospora

 
 
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Disease relevance of Podospora

 

High impact information on Podospora

  • A nonmammalian homolog of the PAF1 gene (Zellweger syndrome) discovered as a gene involved in caryogamy in the fungus Podospora anserina [3].
  • A homologue of the yeast SHE4 gene is essential for the transition between the syncytial and cellular stages during sexual reproduction of the fungus Podospora anserina [4].
  • The Podospora anserina cro1 gene was identified as a gene required for sexual sporulation [4].
  • The first intron of the mitochondrial gene coding for cytochrome oxidase subunit I (COI I1) of Podospora anserina can undergo self-splicing in vitro at high concentrations of NH4Cl or KCl [5].
  • Inactivation of the Podospora anserina vegetative incompatibility locus het-c, whose product resembles a glycolipid transfer protein, drastically impairs ascospore production [6].
 

Biological context of Podospora

 

Anatomical context of Podospora

  • Cytosolic ribosomal mutations that abolish accumulation of circular intron in the mitochondria without preventing senescence of Podospora anserina [11].
  • Utilizing different parts of the 5' regulatory sequence of the Podospora gpd gene, expression vectors containing a dominant selectable marker gene (hygromycin B phosphotransferase) have been constructed for the transformation of P. anserina protoplasts [12].
 

Associations of Podospora with chemical compounds

  • In the fungus Podospora anserina, a double mutant strain which combines two ribosomal mutations exhibits a marked sensitivity to NH4+ acetate [13].
  • The mod-A suppressor of nonallelic heterokaryon incompatibility in Podospora anserina encodes a proline-rich polypeptide involved in female organ formation [14].
  • In Podospora anserina, pex2 mutants exhibit a metabolic defect [inability to grow on medium containing oleic acid (OA medium) as sole carbon source] and a developmental defect (inability to differentiate asci in homozygous crosses) [15].
  • Ribosomal suppressors and antisuppressors in Podospora anserina: resistance to cycloheximide [16].
  • Podospora mutant defective in glucose-dependent growth control [17].
 

Gene context of Podospora

References

  1. Mutations relieving hypersensitivity to paromomycin caused by ribosomal suppressors in Podospora anserina. Coppin-Raynal, E., Le Coze, D. Genet. Res. (1982) [Pubmed]
  2. Structure and expression of the URA5 gene of Saccharomyces cerevisiae. de Montigny, J., Belarbi, A., Hubert, J.C., Lacroute, F. Mol. Gen. Genet. (1989) [Pubmed]
  3. A nonmammalian homolog of the PAF1 gene (Zellweger syndrome) discovered as a gene involved in caryogamy in the fungus Podospora anserina. Berteaux-Lecellier, V., Picard, M., Thompson-Coffe, C., Zickler, D., Panvier-Adoutte, A., Simonet, J.M. Cell (1995) [Pubmed]
  4. A homologue of the yeast SHE4 gene is essential for the transition between the syncytial and cellular stages during sexual reproduction of the fungus Podospora anserina. Berteaux-Lecellier, V., Zickler, D., Debuchy, R., Panvier-Adoutte, A., Thompson-Coffe, C., Picard, M. EMBO J. (1998) [Pubmed]
  5. Self-splicing of the mobile group II intron of the filamentous fungus Podospora anserina (COI I1) in vitro. Schmidt, U., Riederer, B., Mörl, M., Schmelzer, C., Stahl, U. EMBO J. (1990) [Pubmed]
  6. Inactivation of the Podospora anserina vegetative incompatibility locus het-c, whose product resembles a glycolipid transfer protein, drastically impairs ascospore production. Saupe, S., Descamps, C., Turcq, B., Bégueret, J. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  7. Mutations in genes encoding the mitochondrial outer membrane proteins Tom70 and Mdm10 of Podospora anserina modify the spectrum of mitochondrial DNA rearrangements associated with cellular death. Jamet-Vierny, C., Contamine, V., Boulay, J., Zickler, D., Picard, M. Mol. Cell. Biol. (1997) [Pubmed]
  8. The mitochondrial tyrosyl-tRNA synthetase of Podospora anserina is a bifunctional enzyme active in protein synthesis and RNA splicing. Kämper, U., Kück, U., Cherniack, A.D., Lambowitz, A.M. Mol. Cell. Biol. (1992) [Pubmed]
  9. The S12 ribosomal protein of Podospora anserina belongs to the S19 bacterial family and controls the mitochondrial genome integrity through cytoplasmic translation. Dequard-Chablat, M., Sellem, C.H. J. Biol. Chem. (1994) [Pubmed]
  10. Two group I introns with a C.G basepair at the 5' splice-site instead of the very highly conserved U.G basepair: is selection post-translational? Hur, M., Waring, R.B. Nucleic Acids Res. (1995) [Pubmed]
  11. Cytosolic ribosomal mutations that abolish accumulation of circular intron in the mitochondria without preventing senescence of Podospora anserina. Silar, P., Koll, F., Rossignol, M. Genetics (1997) [Pubmed]
  12. Sequence analysis of the gene coding for glyceraldehyde-3-phosphate dehydrogenase (gpd) of Podospora anserina: use of homologous regulatory sequences to improve transformation efficiency. Ridder, R., Osiewacz, H.D. Curr. Genet. (1992) [Pubmed]
  13. Altered ribosomal proteins in mutants of the fungus Podospora anserina. Crouzet, M., Begueret, J. J. Biol. Chem. (1980) [Pubmed]
  14. The mod-A suppressor of nonallelic heterokaryon incompatibility in Podospora anserina encodes a proline-rich polypeptide involved in female organ formation. Barreau, C., Iskandar, M., Loubradou, G., Levallois, V., Bégueret, J. Genetics (1998) [Pubmed]
  15. Identification of six loci in which mutations partially restore peroxisome biogenesis and/or alleviate the metabolic defect of pex2 mutants in podospora. Ruprich-Robert, G., Berteaux-Lecellier, V., Zickler, D., Panvier-Adoutte, A., Picard, M. Genetics (2002) [Pubmed]
  16. Ribosomal suppressors and antisuppressors in Podospora anserina: resistance to cycloheximide. Coppin-Raynal, E. J. Bacteriol. (1977) [Pubmed]
  17. Podospora mutant defective in glucose-dependent growth control. Durrens, P. J. Bacteriol. (1983) [Pubmed]
  18. GRISEA, a copper-modulated transcription factor from Podospora anserina involved in senescence and morphogenesis, is an ortholog of MAC1 in Saccharomyces cerevisiae. Borghouts, C., Osiewacz, H.D. Mol. Gen. Genet. (1998) [Pubmed]
  19. Accelerated cell death in Podospora autophagy mutants. Pinan-Lucarré, B., Balguerie, A., Clavé, C. Eukaryotic Cell (2005) [Pubmed]
  20. DNA sequence analysis of the apocytochrome b gene of Podospora anserina: a new family of intronic open reading frame. Cummings, D.J., Michel, F., McNally, K.L. Curr. Genet. (1989) [Pubmed]
  21. An additional copy of the adenylate cyclase-encoding gene relieves developmental defects produced by a mutation in a vegetative incompatibility-controlling gene in Podospora anserina. Loubradou, G., Bégueret, J., Turcq, B. Gene (1996) [Pubmed]
  22. Stimulation of a mitochondrial endo-exonuclease from Podospora anserina by PCNA. Laquel-Robert, P., Castroviejo, M. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
 
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