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DSTN  -  destrin (actin depolymerizing factor)

Bos taurus

 
 
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Disease relevance of DSTN

  • Total tract digestibilities of DM, ADF, and NDF were determined using Cr2O3, and ruminal in situ loss of DM, ADF, and NDF of hays was estimated using 4 cows fitted with ruminal fistulas [1].
 

High impact information on DSTN

  • After filaments have aged by hydrolysis of their bound ATP and dissociation of the gamma phosphate, ADF/cofilin proteins promote debranching and depolymerization [2].
  • In spermatozoa induced to undergo an acrosome reaction with the calcium ionophore, A23187, further rearrangement occurs with destrin, thymosin beta10, and TS-ACP appearing in the postacrosomal domain [3].
  • Even though T85 had higher concentrations of NDF and ADF than CBG, T85 had 34.1% higher DM yield, 47.9% higher digestible DM, 55.0% higher digestible NDF, 91.7% higher digestible ADF, greater IVDMD, in vitro NDF and ADF disappearances, and higher in situ DM and NDF digestion (P < .05) [4].
  • Tifton 85 bermudagrass had lower concentrations of lignin and ether-linked ferulic acid and greater concentrations of NDF, ADF, hemicellulose, and cellulose than CBG (P < .05) [4].
  • Apparent ruminal digestibilities of ADF (P < .05) and NDF (P < .10) increased linearly as esterification increased [5].
 

Biological context of DSTN

  • Forty-seven cows (24 primiparous) were assigned to one of four normal (20.5%) ADF diets for wk 2 to 5 postpartum [6].
  • Diet 1 (NE1 = 1.65 Mcal/kg, CP = 18%, and ADF = 22%) was fed from start of lactation to at least 4 wk after initiation of treatment [7].
  • Estimated digestibilities of OM, ADF, NDF, and hemicellulose were decreased (P < .05) for BL diets at midgestation, whereas only the fiber portions of the BL diets were decreased at parturition in BL diets compared with hay [8].
  • Digestion kinetics of chemical fractions were determined by simultaneous analysis of the digestion profiles of DM, NDF, ADF, ADL, and acid detergent insoluble ash [9].
  • Content of phenolic acids was correlated neither with ADF, NDF or ADL content (R2 = 1-3%, P > 0.05) nor with CP degradability (R2 = 3% and R2 = 1% for PCA and FA, respectively, P > 0.05) [10].
 

Anatomical context of DSTN

  • Cellulose from alfalfa was degraded at a higher rate than NDF or ADF, indicating that cellulose may be the primary site of hydrolysis of the cell wall in the rumen [11].
  • Digestion of ADF and NDF in the large intestine as a percentage of total tract was unaffected by diet; however, the respective means were 16 and 15, 7 and 7, 5 and 15, and 1 and 1% [12].
  • No differences (P greater than .10) were detected among treatments in OM, NDF, ADF and N digestibilities in the rumen, small intestine or hindgut, but total tract OM digestibility was greater (P less than .10) for SBM and SFS than for C, and total tract N digestibility was greater (P less than .10) for SBM than for C or SFS [13].
  • Daily samples of forage offered and refused and of feces excreted for each steer within period were analyzed for DM, ash, NDF, ADF, and CP [14].
 

Associations of DSTN with chemical compounds

  • Steers fed T85 had higher (P < .05) digestion of DM, OM, NDF, ADF, hemicellulose, and cellulose than steers fed CBG [4].
  • Supplementing diets with urea did not affect DMI; ruminal, postruminal, or total tract digestibilities of DM, starch, ADF, or NDF; ruminal fluid VFA concentrations or molar percentages; or ruminal fluid or particulate dilution rates [15].
  • Ruminal fluid acetate increased and propionate decreased as ADF increased [16].
  • Ruminal digestion of ADF tended to increase with supplemental lasalocid [17].
  • The same concentration of A10255 (20 ppm) decreased ADF digestion less than 20 ppm of monensin [18].
 

Analytical, diagnostic and therapeutic context of DSTN

  • Two isonitrogenous diets differing only in fiber (NDF and ADF) content were used in a crossover design [19].
  • Content of p-coumaric (PCA) and ferulic (FA) acid was determined by the HPLC method in fourteen forbs with a potential utilization as forages (range of nutrient content per kg DM: 100 to 244 g CP, 339 to 528 g NDF and 180-369 g ADF [10].

References

  1. Effects of alfalfa hay of varying fiber fed at 35 or 50% of diet on lactation and nutrient utilization by dairy cows. Alhadhrami, G., Huber, J.T. J. Dairy Sci. (1992) [Pubmed]
  2. Cellular motility driven by assembly and disassembly of actin filaments. Pollard, T.D., Borisy, G.G. Cell (2003) [Pubmed]
  3. Actin and actin-binding proteins in bovine spermatozoa: potential role in membrane remodeling and intracellular signaling during epididymal maturation and the acrosome reaction. Howes, E.A., Hurst, S.M., Jones, R. J. Androl. (2001) [Pubmed]
  4. Comparison of Tifton 85 and Coastal bermudagrasses for yield, nutrient traits, intake, and digestion by growing beef steers. Mandebvu, P., West, J.W., Hill, G.M., Gates, R.N., Hatfield, R.D., Mullinix, B.G., Parks, A.H., Caudle, A.B. J. Anim. Sci. (1999) [Pubmed]
  5. Effects of saturation and esterification of fat sources on site and extent of digestion in steers: ruminal fermentation and digestion of organic matter, fiber, and nitrogen. Elliott, J.P., Drackley, J.K., Aldrich, C.G., Merchen, N.R. J. Anim. Sci. (1997) [Pubmed]
  6. Influence of dietary protein and supplemental niacin on lactational performance of cows fed normal and low fiber diets. Zimmerman, C.A., Rakes, A.H., Daniel, T.E., Hopkins, B.A. J. Dairy Sci. (1992) [Pubmed]
  7. Response to recombinant bovine somatotropin in dairy cows with different genetic merit for milk production. Nytes, A.J., Combs, D.K., Shook, G.E., Shaver, R.D., Cleale, R.M. J. Dairy Sci. (1990) [Pubmed]
  8. Mineral status in beef cows fed broiler litter diets with cation-anion differences or supplemented with hay. Rude, B.J., Rankins, D.L. J. Anim. Sci. (1997) [Pubmed]
  9. Digestion kinetics of alfalfa and wheat straw assuming heterogeneity of the potentially digestible fraction. Van Milgen, J., Berger, L.L., Murphy, M.R. J. Anim. Sci. (1993) [Pubmed]
  10. Content of p-coumaric and ferulic acid in forbs with potential grazing utilization. Komprda, T., Stohandlová, M., Foltýn, J., Pozdísek, J., Míka, V. Archiv für Tierernährung. (1999) [Pubmed]
  11. Observations on in situ degradation of forage cell components in alfalfa and Italian ryegrass. Andrighetto, I., Bailoni, L., Cozzi, G., Tolosa, H.F., Hartman, B., Hinds, M., Sapienza, D. J. Dairy Sci. (1993) [Pubmed]
  12. Nutrient digestion in the large intestine as influenced by forage to concentrate ratio and forage physical form. Siciliano-Jones, J., Murphy, M.R. J. Dairy Sci. (1989) [Pubmed]
  13. Influence of soybean meal and sorghum grain supplementation on intake, digesta kinetics, ruminal fermentation, site and extent of digestion and microbial protein synthesis in beef steers grazing blue grama rangeland. Krysl, L.J., Branine, M.E., Cheema, A.U., Funk, M.A., Galyean, M.L. J. Anim. Sci. (1989) [Pubmed]
  14. Effects of copper oxide bolus administration or high-level copper supplementation on forage utilization and copper status in beef cattle. Arthington, J.D. J. Anim. Sci. (2005) [Pubmed]
  15. Effects of urea and starch on rumen fermentation, nutrient passage to the duodenum, and performance of cows. Cameron, M.R., Klusmeyer, T.H., Lynch, G.L., Clark, J.H., Nelson, D.R. J. Dairy Sci. (1991) [Pubmed]
  16. Influence of dietary fiber and buffer value index on the ruminal milieu of lactating dairy cows. Le Ruyet, P., Tucker, W.B., Hogue, J.F., Aslam, M., Lema, M., Shin, I.S., Miller, T.P., Adams, G.D. J. Dairy Sci. (1992) [Pubmed]
  17. Lasalocid effects on ruminal degradation of protein and postruminal supply of amino acids in Holstein steers. Wessels, R.H., Titgemeyer, E.C., Armendariz, C.K., Jean, G.S. J. Dairy Sci. (1996) [Pubmed]
  18. In vitro effects of the thiopeptide A10255 on ruminal fermentation and microbial populations. Tung, R.S., Kung, L., Slyter, L.L. J. Dairy Sci. (1992) [Pubmed]
  19. Effect of dietary fiber on endogenous nitrogen flows in lactating dairy cows. Ouellet, D.R., Demers, M., Zuur, G., Lobley, G.E., Seoane, J.R., Nolan, J.V., Lapierre, H. J. Dairy Sci. (2002) [Pubmed]
 
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