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Chemical Compound Review

lasalocid     6-[(3R,4S,5S,7R)-7- [(2S,3S,5S)-5-ethyl-5...

Synonyms: Lasalocide, Lasalocido, Lasalocidum, Lasalocide A, Lasalocid A, ...
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Disease relevance of Lasalocid A


Psychiatry related information on Lasalocid A


High impact information on Lasalocid A


Chemical compound and disease context of Lasalocid A


Biological context of Lasalocid A

  • Effects of an inotropic agent, RO 2-2985 (X-537A), on regional blood flow and myocardial function in chronically instrumented conscious dogs and anesthetized dogs [17].
  • These results demonstrate that hydrolysis of ADP-insensitive EP in the catalytic cycle of this enzyme is selectively inhibited by lasalocid [18].
  • These findings suggest that lasalocid is a potentially useful anticryptosporidial agent but that long-term continuous administration may be necessary in the immunocompromised host [19].
  • Comparative studies with the ionophores monensin and lasalocid, which induce effects similar to those observed for OMCTS, indicated that the stimulation of bismuth methylation is not specific for the siloxane and suggested that the stimulation observed is mainly due to facilitated membrane permeation of the metal ion [20].
  • Cellobiose uptake was inhibited by electron transport inhibitors, iron-reactive compounds, proton ionophores, sulfhydryl inhibitors, N,N-dicyclohexylcarbodiimide, and NaF, as well as lasalocid and monensin [21].

Anatomical context of Lasalocid A


Associations of Lasalocid A with other chemical compounds


Gene context of Lasalocid A


Analytical, diagnostic and therapeutic context of Lasalocid A


  1. Bone resorption in organ culture: inhibition by the divalent cation ionophores A23187 and X-537A. Ivey, J.L., Wright, D.R., Tashjian, A.H. J. Clin. Invest. (1976) [Pubmed]
  2. Characterization of the potent in vitro and in vivo antimalarial activities of ionophore compounds. Gumila, C., Ancelin, M.L., Delort, A.M., Jeminet, G., Vial, H.J. Antimicrob. Agents Chemother. (1997) [Pubmed]
  3. Efficacy of lasalocid against murine Pneumocystis carinii pneumonitis. OZ, H.S., Hughes, W.T., Rehg, J.E. Antimicrob. Agents Chemother. (1997) [Pubmed]
  4. The susceptibility of ionophore-resistant Clostridium aminophilum F to other antibiotics. Houlihan, A.J., Russell, J.B. J. Antimicrob. Chemother. (2003) [Pubmed]
  5. Cellular basis for arrhythmogenicity of ionophores with different cation selectivities. Gaide, M.S., Gibson, J.K., Bassett, A.L. Eur. J. Pharmacol. (1984) [Pubmed]
  6. Lasalocid and particle size of corn grain for dairy cows in early lactation. 2. Effect on ruminal measurements and feeding behavior. Knowlton, K.F., Allen, M.S., Erickson, P.S. J. Dairy Sci. (1996) [Pubmed]
  7. Monomeric forms of the acid ionophore lasalocid A (X-537A) from polar solvents. Chiang, C.C., Paul, I.C. Science (1977) [Pubmed]
  8. Free acid, anion, alkali, and alkaline earth complexes of lasalocid a (X537A) in methanol: structural and kinetic studies at the monomer level. Shen, C., Patel, D.J. Proc. Natl. Acad. Sci. U.S.A. (1976) [Pubmed]
  9. Structural and kinetic studies of lasalocid A (X537A) and its silver, sodium, and barium salts in nonpolar solvents. Patel, D.J., Shen, C. Proc. Natl. Acad. Sci. U.S.A. (1976) [Pubmed]
  10. Use of calcium ionophores to determine the effects of intracellular calcium on the action potential of canine cardiac Purkinje fibers. Gelles, J.M. Circ. Res. (1977) [Pubmed]
  11. Effects of the antibiotic ionophore X-537A on contractility and ionic exchange in rabbit ventricular myocardium. Wendt, I.R., Langer, G.A. Circ. Res. (1977) [Pubmed]
  12. Evaluation of decoquinate, lasalocid, and monensin against experimentally induced sarcocystosis in calves. Foreyt, W.J. Am. J. Vet. Res. (1986) [Pubmed]
  13. Chemoprophylaxis of cryptosporidiosis in chickens, using halofuginone, salinomycin, lasalocid, or monensin. Lindsay, D.S., Blagburn, B.L., Sundermann, C.A., Ernest, J.A. Am. J. Vet. Res. (1987) [Pubmed]
  14. Eating barley too frequently or in excess decreases lambs' preference for barley but sodium bicarbonate and lasalocid attenuate the response. Phy, T.S., Provenza, F.D. J. Anim. Sci. (1998) [Pubmed]
  15. The relationship of maximum or intermediate coccidiostat levels to broiler chick water intake. Damron, B.L. Poult. Sci. (1994) [Pubmed]
  16. Reduction of 3-methylindole production and prevention of acute bovine pulmonary edema and emphysema with lasalocid. Nocerini, M.R., Honeyfield, D.C., Carlson, J.R., Breeze, R.G. J. Anim. Sci. (1985) [Pubmed]
  17. Effects of an inotropic agent, RO 2-2985 (X-537A), on regional blood flow and myocardial function in chronically instrumented conscious dogs and anesthetized dogs. Hanley, H.G., Lewis, R.M., Hartley, C.J., Franklin, D., Schwartz, A. Circ. Res. (1975) [Pubmed]
  18. Selective inhibition by lasalocid of hydrolysis of the ADP-insensitive phosphoenzyme in the catalytic cycle of sarcoplasmic reticulum Ca2(+)-ATPase. Kawashima, T., Hara, H., Kanazawa, T. J. Biol. Chem. (1990) [Pubmed]
  19. Anticryptosporidial activity of lasalocid and other ionophorous antibiotics in immunosuppressed rats. Rehg, J.E. J. Infect. Dis. (1993) [Pubmed]
  20. Effect of Octamethylcyclotetrasiloxane on Methylation of Bismuth by Methanosarcina barkeri. Michalke, K., Meyer, J., Hensel, R. Appl. Environ. Microbiol. (2006) [Pubmed]
  21. Cellobiose uptake and metabolism by Ruminococcus flavefaciens. Helaszek, C.T., White, B.A. Appl. Environ. Microbiol. (1991) [Pubmed]
  22. Effects of an ionophore, X-537A, on mouse CNS cultures: a light and electron microscope study. Tessler, A.R., Kim, S.U., Gonatas, N.K. J. Neuropathol. Exp. Neurol. (1976) [Pubmed]
  23. Effects of the ionophore X-537A on acetylcholine release at the frog neuromuscular junction. Kita, H., Van Der Kloot, W. J. Physiol. (Lond.) (1976) [Pubmed]
  24. Stimulus-secretion coupling in rat pancreas: role of sodium, calcium and cyclic nucleotides studied by X-537A and BrX-537A. Singh, M. J. Physiol. (Lond.) (1980) [Pubmed]
  25. Interleukin-1 beta maturation and release in response to ATP and nigericin. Evidence that potassium depletion mediated by these agents is a necessary and common feature of their activity. Perregaux, D., Gabel, C.A. J. Biol. Chem. (1994) [Pubmed]
  26. Hydroxyl deformation frequencies as a probe of hydrogen bonding in lasalocid A (X-537A) and its sodium complex. Phillies, G.D., Stanley, H.E. J. Am. Chem. Soc. (1976) [Pubmed]
  27. A comparison of data analysis methods for determining gas phase stabilities by CID: alkali metal complexes of polyether ionophore antibiotics. Forbes, M.W., Volmer, D.A., Francis, G.J., Böhme, D.K. J. Am. Soc. Mass Spectrom. (2005) [Pubmed]
  28. Anticryptosporidial activity of ranalexin, lasalocid and azithromycin alone and in combination in cell lines. Giacometti, A., Cirioni, O., Barchiesi, F., Scalise, G. J. Antimicrob. Chemother. (2000) [Pubmed]
  29. In-vitro activities of paromomycin and lasalocid evaluated in combination against Cryptosporidium parvum. You, X., Schinazi, R.F., Arrowood, M.J., Lejkowski, M., Juodawlkis, A.S., Mead, J.R. J. Antimicrob. Chemother. (1998) [Pubmed]
  30. Golgi apparatus and lectin-binding sites. Effects of Lasalocid (X537A). Garfield, R.E., Somlyo, A.P. Exp. Cell Res. (1977) [Pubmed]
  31. Parallel but separate release of catecholamines and acetylcholinesterase from stimulated adrenal chromaffin cells in culture. Mizobe, F., Iwamoto, M., Livett, B.G. J. Neurochem. (1984) [Pubmed]
  32. Fragmentation studies on lasalocid acid by accurate mass electrospray mass spectrometry. Lopes, N.P., Gates, P.J., Wilkins, J.P., Staunton, J. The Analyst. (2002) [Pubmed]
  33. Improvement of chemical analysis of antibiotics. XI. Simultaneous fluorodensitometric determination of polyether antibiotics. Asukabe, H., Yoneyama, H., Mori, Y., Harada, K., Suzuki, M., Oka, H. J. Chromatogr. (1987) [Pubmed]
  34. The ionic sensitivity of secretion-associated organelles in root cap cells of maize. Robinson, D.G. Eur. J. Cell Biol. (1981) [Pubmed]
  35. Influence of solvent and of cation size on the conformations of lasalocid A-lanthanide(III) ion complexes: circular dichroism and fluorescence studies. Shastri, B.P., Sankaram, M.B., Easwaran, K.R. Biochemistry (1987) [Pubmed]
  36. A rapid method for the determination of lasalocid in animal tissues and eggs by high performance liquid chromatography with fluorescence detection and confirmation by LC-MS-MS. Matabudul, D.K., Conway, B., Lumley, I.D. The Analyst. (2000) [Pubmed]
  37. A differential scanning calorimetry study of the interaction of lasalocid antibiotic with phospholipid bilayers. Tahir, A., Grabielle-Madelmont, C., Betrencourt, C., Ollivon, M., Peretti, P. Chem. Phys. Lipids (1999) [Pubmed]
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