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Gene Review

RBFOX1  -  RNA binding protein, fox-1 homolog (C....

Homo sapiens

Synonyms: 2BP1, A2BP, A2BP1, Ataxin-2-binding protein 1, FOX-1, ...
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Disease relevance of A2BP1

  • The structural gene of FOX-1 (blaFOX-1) was cloned into a 2,270-bp PstI-PstI fragment and was expressed in E. coli TG1 [1].
  • The deduced 382-amino-acid sequence of FOX-1 exhibited a high degree of similarity with chromosomally encoded AmpC beta-lactamases of Pseudomonas aeruginosa, Serratia marcescens, Enterobacter cloacae, E. coli, and Citrobacter freundii [1].

Psychiatry related information on A2BP1


High impact information on A2BP1


Biological context of A2BP1


Anatomical context of A2BP1


Associations of A2BP1 with chemical compounds


Physical interactions of A2BP1


Other interactions of A2BP1

  • The results presented here underline previous findings about the interaction of human ataxin-2 and A2BP1 [7].
  • Measurement of urinary hydrogen peroxide by FOX-1 method in conjunction with catalase in diabetes mellitus--a sensitive and specific approach [8].

Analytical, diagnostic and therapeutic context of A2BP1


  1. Gene sequence and biochemical characterization of FOX-1 from Klebsiella pneumoniae, a new AmpC-type plasmid-mediated beta-lactamase with two molecular variants. Gonzalez Leiza, M., Perez-Diaz, J.C., Ayala, J., Casellas, J.M., Martinez-Beltran, J., Bush, K., Baquero, F. Antimicrob. Agents Chemother. (1994) [Pubmed]
  2. The de novo chromosome 16 translocations of two patients with abnormal phenotypes (mental retardation and epilepsy) disrupt the A2BP1 gene. Bhalla, K., Phillips, H.A., Crawford, J., McKenzie, O.L., Mulley, J.C., Eyre, H., Gardner, A.E., Kremmidiotis, G., Callen, D.F. J. Hum. Genet. (2004) [Pubmed]
  3. A novel protein with RNA-binding motifs interacts with ataxin-2. Shibata, H., Huynh, D.P., Pulst, S.M. Hum. Mol. Genet. (2000) [Pubmed]
  4. Characterization of FOX-3, an AmpC-type plasmid-mediated beta-lactamase from an Italian isolate of Klebsiella oxytoca. Marchese, A., Arlet, G., Schito, G.C., Lagrange, P.H., Philippon, A. Antimicrob. Agents Chemother. (1998) [Pubmed]
  5. Tissue-dependent isoforms of mammalian Fox-1 homologs are associated with tissue-specific splicing activities. Nakahata, S., Kawamoto, S. Nucleic Acids Res. (2005) [Pubmed]
  6. Measurement of plasma hydroperoxide concentration by FOX-1 assay in conjunction with triphenylphosphine. Banerjee, D., Madhusoodanan, U.K., Sharanabasappa, M., Ghosh, S., Jacob, J. Clin. Chim. Acta (2003) [Pubmed]
  7. The ortholog of human ataxin-2 is essential for early embryonic patterning in C. elegans. Kiehl, T.R., Shibata, H., Pulst, S.M. J. Mol. Neurosci. (2000) [Pubmed]
  8. Measurement of urinary hydrogen peroxide by FOX-1 method in conjunction with catalase in diabetes mellitus--a sensitive and specific approach. Banerjee, D., Jacob, J., Kunjamma, G., Madhusoodanan, U.K., Ghosh, S. Clin. Chim. Acta (2004) [Pubmed]
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