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Gene Review

PRMT6  -  protein arginine methyltransferase 6

Homo sapiens

Synonyms: FLJ10559, HRMT1L6, Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6, Histone-arginine N-methyltransferase PRMT6, Protein arginine N-methyltransferase 6
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Disease relevance of PRMT6


High impact information on PRMT6


Chemical compound and disease context of PRMT6


Associations of PRMT6 with chemical compounds

  • Upon retinoic acid-induced transcriptional activation of HoxA2 in a cell model of neuronal differentiation, PRMT6 recruitment and H3 R2 methylation are diminished and H3 K4 trimethylation increases at the gene [5].
  • We speculate that the increased catalytic efficiency of PRMT6 for methylated substrates combined with lower K(m) values for native protein methyl acceptors may obscure this distributive mechanism to produce an apparently processive mechanism [6].

Biological context of PRMT6


Regulatory relationships of PRMT6


  1. Arginine Methylation of the Human Immunodeficiency Virus Type 1 Tat Protein by PRMT6 Negatively Affects Tat Interactions with both Cyclin T1 and the Tat Transactivation Region. Xie, B., Invernizzi, C.F., Richard, S., Wainberg, M.A. J. Virol. (2007) [Pubmed]
  2. Arginine methylation regulates DNA polymerase beta. El-Andaloussi, N., Valovka, T., Toueille, M., Steinacher, R., Focke, F., Gehrig, P., Covic, M., Hassa, P.O., Schär, P., Hübscher, U., Hottiger, M.O. Mol. Cell (2006) [Pubmed]
  3. The AT-hook of the chromatin architectural transcription factor high mobility group A1a is arginine-methylated by protein arginine methyltransferase 6. Sgarra, R., Lee, J., Tessari, M.A., Altamura, S., Spolaore, B., Giancotti, V., Bedford, M.T., Manfioletti, G. J. Biol. Chem. (2006) [Pubmed]
  4. The novel human protein arginine N-methyltransferase PRMT6 is a nuclear enzyme displaying unique substrate specificity. Frankel, A., Yadav, N., Lee, J., Branscombe, T.L., Clarke, S., Bedford, M.T. J. Biol. Chem. (2002) [Pubmed]
  5. PRMT6-mediated methylation of R2 in histone H3 antagonizes H3 K4 trimethylation. Hyllus, D., Stein, C., Schnabel, K., Schiltz, E., Imhof, A., Dou, Y., Hsieh, J., Bauer, U.M. Genes Dev. (2007) [Pubmed]
  6. A kinetic study of human protein arginine N-methyltransferase 6 reveals a distributive mechanism. Lakowski, T.M., Frankel, A. J. Biol. Chem. (2008) [Pubmed]
  7. Methylation of Tat by PRMT6 regulates human immunodeficiency virus type 1 gene expression. Boulanger, M.C., Liang, C., Russell, R.S., Lin, R., Bedford, M.T., Wainberg, M.A., Richard, S. J. Virol. (2005) [Pubmed]
  8. Thrombospondin-1 is a transcriptional repression target of PRMT6. Michaud-Levesque, J., Richard, S. J. Biol. Chem. (2009) [Pubmed]
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