Disease relevance of CDCA7L

• The transfection of R1 in a human neuroblastoma cell line, SK-N-BE (2)-C, inhibited the monoamine oxidase A promoter and enzymatic activity [1].
• Complementary DNA probes of R1 and R14 genes 5 were used in Northern blot hybridization and indicated the presence of at least two gene 5 alleles among Melbourne G9 rotaviruses [2].

High impact information on CDCA7L

• This study reports the roles of MAO A and R1 in apoptosis and proliferation [3].
• Immunoprecipitation and immunohistochemistry experiments indicate that the oncogene c-Myc colocalizes with R1 and induces R1 gene expression [3].
• In addition, dexamethasone induces R1 translocation from the cytosol to the nucleus in a time-dependent manner in both the neuroblastoma and wild-type UW228 cell lines but not in R1 knock-down UW228 cells [4].
• Glucocorticoid and androgen activation of monoamine oxidase A is regulated differently by R1 and Sp1 [4].
• Taken together, this study shows that R1 is a novel repressor that inhibits monoamine oxidase A gene expression [1].

Biological context of CDCA7L

• The R1 cDNA encodes a protein with 454 amino acids and an open reading frame at the 5'-end [1].
• After treatment, the restoration of IFN- gamma R1 at both mRNA and protein levels, coupled with down-regulation of counteracting cytokines, may facilitate the action of signals associated with IFN- gamma , yielding parasite clearance [5].
• Phylogenetic analysis indicated that while all isolates clustered into one group containing the Wa NSP4 allele (genotype 1), isolate R1 was most closely related to Wa [2].
• Nucleotide sequence analysis revealed that isolates carrying the R14 gene 5 shared 94-98% sequence identities with one another, while sequence identity to R1 was 78% [2].
• Northern hybridization analysis with a whole genome probe derived from the prototype G9 strain, F45, revealed that the NSP1 gene (gene 5) of two isolates (R1 and R14) did not exhibit significant homology [2].

Anatomical context of CDCA7L

• Immunocytochemical analysis showed that R1 was expressed in both cytosol and nucleus, which suggested a role for R1 in transcriptional regulation [1].
• This so-called isthmic organizer (IsO) secretes signaling molecules, such as fibroblast growth factors (FGFs), which regulate cellular survival, patterning and proliferation in the midbrain and rhombomere 1 (R1) of the hindbrain [6].
• Hypothalamus and amygdala showed changes related to the task but not specific to spatial learning while in hippocampus, pro-TRH and TRH-R1 mRNA levels were specifically increased in those animals trained to find a hidden platform [7].

Associations of CDCA7L with chemical compounds

• Thus, the dissociations of Si2H6 to produce SiH2 + SiH4 (R1) and H3SiSiH + H2 (R2) both proceed through tight inner transition states followed by loose outer transition states [8].

Other interactions of CDCA7L

• R1, a novel repressor of the human monoamine oxidase A [1].

Analytical, diagnostic and therapeutic context of CDCA7L

• Northern blot analysis revealed the presence of endogenous R1 mRNA in human brain and peripheral tissues [1].
• TRH content and TSH serum levels were determined by radioimmunoassay; mRNA levels of pro-TRH, TRH-R1, TRH-R2, and PPII, by RT-PCR [7].
• Exclusive changes due to spatial training were observed in posterior hippocampus of rats trained for 5 days sacrificed after 60min: decreased TRH content and increased mRNA levels of pro-TRH and TRH-R1, particularly in CA3 region (measured by in situ hybridization) [7].

References