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SLC2A9  -  solute carrier family 2 (facilitated...

Homo sapiens

Synonyms: GLUT-9, GLUT9, GLUTX, Glucose transporter type 9, Glut9, ...
 
 
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High impact information on SLC2A9

 

Biological context of SLC2A9

 

Anatomical context of SLC2A9

 

Associations of SLC2A9 with chemical compounds

  • IL-1beta induces an increased expression of glucose transporter (GLUT) 1 mRNA and protein, and GLUT9 mRNA [6].
 

Other interactions of SLC2A9

  • Human articular chondrocytes express three facilitative glucose transporter isoforms: GLUT1, GLUT3 and GLUT9 [4].
  • GLUT9 did not bind cytochalasin B as shown by a cytochalasin B binding assay, indicating a similar behavior of GLUT9 compared with GLUT5 [1].
  • RESULTS: We identified 2 novel genes (GLUT8 and GLUT9) that are members of the facilitative glucose transporter family [7].
 

Analytical, diagnostic and therapeutic context of SLC2A9

  • Western blotting confirmed the presence of the GLUT1 protein which migrated between the 50 and 64 kDa markers and two specific GLUT9 bands migrating under the 50 and 60 kDa markers, respectively [5].
  • We have previously used RT-PCR to show that fully developed human articular chondrocytes express transcripts for the GLUT1 and GLUT9 glucose transporters [5].

References

  1. Identification and characterization of human glucose transporter-like protein-9 (GLUT9): alternative splicing alters trafficking. Augustin, R., Carayannopoulos, M.O., Dowd, L.O., Phay, J.E., Moley, J.F., Moley, K.H. J. Biol. Chem. (2004) [Pubmed]
  2. Cloning and expression analysis of a novel member of the facilitative glucose transporter family, SLC2A9 (GLUT9). Phay, J.E., Hussain, H.B., Moley, J.F. Genomics (2000) [Pubmed]
  3. Sequence and functional analysis of GLUT10: a glucose transporter in the Type 2 diabetes-linked region of chromosome 20q12-13.1. Dawson, P.A., Mychaleckyj, J.C., Fossey, S.C., Mihic, S.J., Craddock, A.L., Bowden, D.W. Mol. Genet. Metab. (2001) [Pubmed]
  4. Human articular chondrocytes express three facilitative glucose transporter isoforms: GLUT1, GLUT3 and GLUT9. Mobasheri, A., Neama, G., Bell, S., Richardson, S., Carter, S.D. Cell Biol. Int. (2002) [Pubmed]
  5. Expression of the GLUT1 and GLUT9 facilitative glucose transporters in embryonic chondroblasts and mature chondrocytes in ovine articular cartilage. Mobasheri, A., Dobson, H., Mason, S.L., Cullingham, F., Shakibaei, M., Moley, J.F., Moley, K.H. Cell Biol. Int. (2005) [Pubmed]
  6. Cytokine regulation of facilitated glucose transport in human articular chondrocytes. Shikhman, A.R., Brinson, D.C., Valbracht, J., Lotz, M.K. J. Immunol. (2001) [Pubmed]
  7. Strategy for identification of novel glucose transporter family members by using internet-based genomic databases. Phay, J.E., Hussain, H.B., Moley, J.F. Surgery (2000) [Pubmed]
 
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