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Gene Review

PSMB4  -  proteasome (prosome, macropain) subunit,...

Homo sapiens

Synonyms: 26 kDa prosomal protein, HN3, HsBPROS26, HsN3, Macropain beta chain, ...
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Disease relevance of PSMB4


High impact information on PSMB4


Biological context of PSMB4

  • Sequence analyses and inter-species comparisons of three novel human proteasomal subunits, HsN3, HsC7-I and HsC10-II, confine potential proteolytic active-site residues [8].
  • Here we report the nucleotide sequences of three human proteasomal subunits, HsN3, HsC7-I and HsC10-II, coding for proteins with 264, 201 and 205 amino acid residues with calculated molecular weights of 29,192, 22,836 and 22,931, respectively [8].
  • Computationally, molecular structures, vibrational frequencies and adsorption energies of possible adsorbates including HN3 and its derivatives, N3, N2, NH, and H, have been predicted by first-principles calculations based on the density functional theory (DFT) and the pseudopotential method [9].

Anatomical context of PSMB4


Associations of PSMB4 with chemical compounds

  • Protonated molecules, obtained by CI(NH3) of azidofuranosyl derivatives, lose HN3 giving abundant furanosyl (S+) ions [12].
  • Following arsenite treatment or irradiation, a significant increase compared with that of the control was observed for glutathione (GSH) transferase omega 1 and proteasome subunit beta type 4 precursor [13].
  • Rat dosing experiments confirmed that EDEA, MDEA, and TEA could be detected in urine for at least 48 h after exposure to HN1, HN2, and HN3, respectively [14].
  • It was also observed at ultrasonic intensities exceeding 3.5 W cm-2 that the decomposition of HN3 led to the accumulation of NH4+ in solution [15].
  • The kinetics of N2H5+ decomposition and initial HN3 formation increase in a linear manner with the HNO3 concentration (from 1 to 6 M) and with the ultrasonic intensity (from 0.5 to 3.1 W cm-2) [15].

Physical interactions of PSMB4


Analytical, diagnostic and therapeutic context of PSMB4

  • Reactions of N3, the product of the reaction of HO with HN3, were studied in an environmental chamber using an FTIR spectrometer for end-product analysis [17].


  1. Application of gibberelic acid (GA) alone or together wih cytostatics in treatment of lung cancer. Miklussák, S., Schwartz, E., Dornetzhuber, V., Badalík, L., Laczko, V., Krcová, M., Laczková, A., Rajecová, S., Zemková, O. Neoplasma (1980) [Pubmed]
  2. Genome-wide analysis of oral cancer--early results from the Cancer Genome Anatomy Project. Shillitoe, E.J., May, M., Patel, V., Lethanakul, C., Ensley, J.F., Strausberg, R.L., Gutkind, J.S. Oral Oncol. (2000) [Pubmed]
  3. The human proteasome subunit HsN3 is located in the inner rings of the complex dimer. Kopp, F., Kristensen, P., Hendil, K.B., Johnsen, A., Sobek, A., Dahlmann, B. J. Mol. Biol. (1995) [Pubmed]
  4. Evidence for multiple substrate-reduction sites and distinct inhibitor-binding sites from an altered Azotobacter vinelandii nitrogenase MoFe protein. Shen, J., Dean, D.R., Newton, W.E. Biochemistry (1997) [Pubmed]
  5. Synthesis and antiretrovirus properties of 5'-isocyano-5'-deoxythymidine, 5'-isocyano-2',5'-dideoxyuridine, 3'-azido-5'-isocyano-3',5'-dideoxythymidine, and 3'-azido-5'-isocyano-2',3',5'-trideoxyuridine. Hiebl, J., Zbiral, E., Balzarini, J., De Clercq, E. J. Med. Chem. (1991) [Pubmed]
  6. Association between HTLV-1 Tax and I kappa B alpha is dependent on the I kappa B alpha phosphorylation state. Petropoulos, L., Hiscott, J. Virology (1998) [Pubmed]
  7. Genetic relationships of the genes encoding the human proteasome beta subunits and the proteasome PA28 complex. McCusker, D., Jones, T., Sheer, D., Trowsdale, J. Genomics (1997) [Pubmed]
  8. Sequence analyses and inter-species comparisons of three novel human proteasomal subunits, HsN3, HsC7-I and HsC10-II, confine potential proteolytic active-site residues. Nothwang, H.G., Tamura, T., Tanaka, K., Ichihara, A. Biochim. Biophys. Acta (1994) [Pubmed]
  9. Reactions of hydrazoic acid on TiO2 nanoparticles: an experimental and computational study. Wang, J.H., Lin, M.C., Sun, Y.C. The journal of physical chemistry. B, Condensed matter, materials, surfaces, interfaces & biophysical. (2005) [Pubmed]
  10. Reactions of the trifunctional nitrogen mustard tris(2-chloroethyl)-amine (HN3) with human erythrocyte membranes in vitro. Wildenauer, D., Weger, N. Biochem. Pharmacol. (1979) [Pubmed]
  11. The lack of effects of alkylating agents on mammalian cell membranes. Ankel, E.G., Ring, B.J., Lai, C.S., Holcenberg, J.S. International journal of tissue reactions. (1986) [Pubmed]
  12. Reactivity of anomeric 1alpha- and 1beta-pentofuranosyl azide derivatives in ammonia chemical ionization. Kralj, B., Kocjan, D., Kobe, J. Rapid Commun. Mass Spectrom. (2001) [Pubmed]
  13. Combined effects of gamma radiation and arsenite on the proteome of human TK6 lymphoblastoid cells. Tapio, S., Danescu-Mayer, J., Asmuss, M., Posch, A., Gomolka, M., Hornhardt, S. Mutat. Res. (2005) [Pubmed]
  14. Quantitation of biomarkers of exposure to nitrogen mustards in urine from rats dosed with nitrogen mustards and from an unexposed human population. Lemire, S.W., Barr, J.R., Ashley, D.L., Olson, C.T., Hayes, T.L. Journal of analytical toxicology. (2004) [Pubmed]
  15. Kinetics of hydrazinium nitrate decomposition in nitric acid solutions under the effect of power ultrasound. Venault, L., Moisy, P., Blanc, P., Madic, C. Ultrasonics sonochemistry. (2001) [Pubmed]
  16. A novel link between the proteasome pathway and the signal transduction pathway of the bone morphogenetic proteins (BMPs). Lin, Y., Martin, J., Gruendler, C., Farley, J., Meng, X., Li, B.Y., Lechleider, R., Huff, C., Kim, R.H., Grasser, W.A., Paralkar, V., Wang, T. BMC Cell Biol. (2002) [Pubmed]
  17. Atmospheric chemistry of hydrazoic acid (HN3): UV absorption spectrum, HO reaction rate, and reactions of the N3 radical. Orlando, J.J., Tyndall, G.S., Betterton, E.A., Lowry, J., Stegall, S.T. Environ. Sci. Technol. (2005) [Pubmed]
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