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MeSH Review

Cardiovascular Physiology

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Disease relevance of Cardiovascular Physiology


High impact information on Cardiovascular Physiology


Biological context of Cardiovascular Physiology


Anatomical context of Cardiovascular Physiology


Associations of Cardiovascular Physiology with chemical compounds


Gene context of Cardiovascular Physiology

  • Besides their action in cardiovascular physiology, NPs have been described as anti-inflammatory regulators of macrophage function: they have been reported to inhibit the induction of inflammatory mediators, such as iNOS, COX-2, and TNF-alpha [19].
  • To examine the role of liver-derived IGF-I in cardiovascular physiology, liver-derived IGF-I was inactivated at 4 wk of age, resulting in a 79% reduction of serum IGF-I levels [20].
  • Although hepatic CYP have been studied extensively, the role of CYP in cardiovascular physiology and disease is poorly understood [21].
  • Thus, AT1 47 provides us with a powerful tool to selectively silence this subtype of receptor to investigate its role in cardiovascular physiology [22].
  • In contrast, genetic ablation of SR-BI has a negative effect on cardiovascular physiology in both males and females and a gender specific negative impact on female fertility [23].

Analytical, diagnostic and therapeutic context of Cardiovascular Physiology


  1. A mineralocorticoid receptor mutation causing human hypertension. Geller, D.S. Curr. Opin. Nephrol. Hypertens. (2001) [Pubmed]
  2. Balancing tissue perfusion demands: cardiovascular dynamics of Cancer magister during exposure to low salinity and hypoxia. McGaw, I.J., McMahon, B.R. J. Exp. Zoolog. Part A Comp. Exp. Biol. (2003) [Pubmed]
  3. Role of the cardiac renin-angiotensin system in human heart failure. Paul, M., Stock, P., Langheinrich, M., Liefeldt, L., Schönfelder, G., Böhm, M. Adv. Exp. Med. Biol. (1995) [Pubmed]
  4. Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y. Erickson, J.C., Clegg, K.E., Palmiter, R.D. Nature (1996) [Pubmed]
  5. Estrogen receptor alpha mediates the nongenomic activation of endothelial nitric oxide synthase by estrogen. Chen, Z., Yuhanna, I.S., Galcheva-Gargova, Z., Karas, R.H., Mendelsohn, M.E., Shaul, P.W. J. Clin. Invest. (1999) [Pubmed]
  6. Identification of atrial natriuretic factor gene transcripts in the central nervous system of the rat. Gardner, D.G., Vlasuk, G.P., Baxter, J.D., Fiddes, J.C., Lewicki, J.A. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  7. Cardiomyocyte-specific endothelin A receptor knockout mice have normal cardiac function and an unaltered hypertrophic response to angiotensin II and isoproterenol. Kedzierski, R.M., Grayburn, P.A., Kisanuki, Y.Y., Williams, C.S., Hammer, R.E., Richardson, J.A., Schneider, M.D., Yanagisawa, M. Mol. Cell. Biol. (2003) [Pubmed]
  8. Identification of calcium-modulating cyclophilin ligand (CAML) as transducer of angiotensin II-mediated nuclear factor of activated T cells (NFAT) activation. Guo, S., Lopez-Ilasaca, M., Dzau, V.J. J. Biol. Chem. (2005) [Pubmed]
  9. Recent progress in T-cadherin (CDH13, H-cadherin) research. Takeuchi, T., Ohtsuki, Y. Histol. Histopathol. (2001) [Pubmed]
  10. Elevation of plasma homocysteine in natural menopause can not be explained by a lack of vitamin coenzyme availability: relevance to the risk of cardiovascular disease. Masse, P.G., Dosy, J., Cole, D.E., Evrovski, J., Mahuren, J.D., Coburn, S.P. The journal of nutrition, health & aging. (2005) [Pubmed]
  11. The PPAR genes, cardiovascular disease and the emergence of PPAR pharmacogenetics. Cresci, S. Expert opinion on pharmacotherapy. (2005) [Pubmed]
  12. Mechanisms of impaired vascular response to ANG II in perivascular injured carotid arteries of ovariectomized rat. Fukada, S.Y., Iyomasa, M.M., Cunha, F.Q., Corrêa, F.M., de Oliveira, A.M. J. Cardiovasc. Pharmacol. (2004) [Pubmed]
  13. Abnormal vascular function and hypertension in mice deficient in estrogen receptor beta. Zhu, Y., Bian, Z., Lu, P., Karas, R.H., Bao, L., Cox, D., Hodgin, J., Shaul, P.W., Thoren, P., Smithies, O., Gustafsson, J.A., Mendelsohn, M.E. Science (2002) [Pubmed]
  14. Modulation of cardiac Ca2+ channel by Gq-activating neurotransmitters reconstituted in Xenopus oocytes. Weiss, S., Doan, T., Bernstein, K.E., Dascal, N. J. Biol. Chem. (2004) [Pubmed]
  15. Implications of local angiotensin production in cardiovascular physiology and pharmacology. Dzau, V.J. Am. J. Cardiol. (1987) [Pubmed]
  16. Apraclonidine and brimonidine effects on anterior ocular and cardiovascular physiology in normal and sympathectomized monkeys. Gabelt, B.T., Robinson, J.C., Hubbard, W.C., Peterson, C.M., Debink, N., Wadhwa, A., Kaufman, P.L. Exp. Eye Res. (1994) [Pubmed]
  17. Arginine metabolism in vascular biology and disease. Morris, S.M. Vascular medicine (London, England) (2005) [Pubmed]
  18. Nutritional aspects of nitric oxide: human health implications and therapeutic opportunities. Janero, D.R. Nutrition (Burbank, Los Angeles County, Calif.) (2001) [Pubmed]
  19. Vasoprotective actions of the atrial natriuretic peptide. Kiemer, A.K., Fürst, R., Vollmar, A.M. Current medicinal chemistry. Cardiovascular and hematological agents. (2005) [Pubmed]
  20. Liver-derived insulin-like growth factor-I is involved in the regulation of blood pressure in mice. Tivesten, A., Bollano, E., Andersson, I., Fitzgerald, S., Caidahl, K., Sjögren, K., Skøtt, O., Liu, J.L., Mobini, R., Isaksson, O.G., Jansson, J.O., Ohlsson, C., Bergström, G., Isgaard, J. Endocrinology (2002) [Pubmed]
  21. Cytochrome p450 enzymes and cardiovascular disease. Hunter, A.L., Cruz, R.P., Cheyne, B.M., McManus, B.M., Granville, D.J. Can. J. Physiol. Pharmacol. (2004) [Pubmed]
  22. Selective silencing of angiotensin receptor subtype 1a (AT1aR) by RNA interference. Vázquez, J., Correa de Adjounian, M.F., Sumners, C., González, A., Diez-Freire, C., Raizada, M.K. Hypertension (2005) [Pubmed]
  23. Estrogen regulation of the scavenger receptor class B gene: Anti-atherogenic or steroidogenic, is there a priority? Lopez, D., McLean, M.P. Mol. Cell. Endocrinol. (2006) [Pubmed]
  24. Cardiovascular physiology in a case of heterotopic cardiac transplantation. Melvin, K.R., Pollick, C., Hunt, S.A., McDougall, R., Goris, M.L., Oyer, P., Popp, R.L., Stinson, E.B. Am. J. Cardiol. (1982) [Pubmed]
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