Gene Review:
Syk - spleen tyrosine kinase
Mus musculus
Synonyms:
Spleen tyrosine kinase, Sykb, Tyrosine-protein kinase SYK, ptk72
Saxon,
Ferrini,
Mócsai,
Vántus,
Tomohiro Miki,
Zhang,
Siraganian,
Berton,
Ligeti,
Yukio Yamori,
Costello,
Turner,
Reth,
Crowley,
Santini,
Ikuo Morita,
DeFranco,
Yamada,
Katsumi Ikeda,
Jin-Wen Xu,
Schreiber,
Gozzini,
Sada,
Meng,
Zhang,
Lowell,
Tybulewicz,
Lowell,
Kepley,
Jakus,
Wienands,
Fitzer-Attas,
Scappini,
Terada,
Indik,
Zhu,
Suzuki,
- The immunomodulatory adapter proteins DAP12 and Fc receptor gamma-chain (FcRgamma) regulate development of functional osteoclasts through the Syk tyrosine kinase. Mócsai, A., Humphrey, M.B., Van Ziffle, J.A., Hu, Y., Burghardt, A., Spusta, S.C., Majumdar, S., Lanier, L.L., Lowell, C.A., Nakamura, M.C. Proc. Natl. Acad. Sci. U.S.A. (2004)
- B cell antigen receptor desensitization: disruption of receptor coupling to tyrosine kinase activation. Vilen, B.J., Famiglietti, S.J., Carbone, A.M., Kay, B.K., Cambier, J.C. J. Immunol. (1997)
- R406, an orally available spleen tyrosine kinase inhibitor blocks fc receptor signaling and reduces immune complex-mediated inflammation. Braselmann, S., Taylor, V., Zhao, H., Wang, S., Sylvain, C., Baluom, M., Qu, K., Herlaar, E., Lau, A., Young, C., Wong, B.R., Lovell, S., Sun, T., Park, G., Argade, A., Jurcevic, S., Pine, P., Singh, R., Grossbard, E.B., Payan, D.G., Masuda, E.S. J. Pharmacol. Exp. Ther. (2006)
- Mac-1 signaling via Src-family and Syk kinases results in elastase-dependent thrombohemorrhagic vasculopathy. Hirahashi, J., Mekala, D., Van Ziffle, J., Xiao, L., Saffaripour, S., Wagner, D.D., Shapiro, S.D., Lowell, C., Mayadas, T.N. Immunity (2006)
- Syk expression in endothelial cells and their morphologic defects in embryonic Syk-deficient mice. Yanagi, S., Inatome, R., Ding, J., Kitaguchi, H., Tybulewicz, V.L., Yamamura, H. Blood (2001)
- Syk, c-Src, the alphavbeta3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorption. Zou, W., Kitaura, H., Reeve, J., Long, F., Tybulewicz, V.L., Shattil, S.J., Ginsberg, M.H., Ross, F.P., Teitelbaum, S.L. J. Cell Biol. (2007)
- Initiation and processing of signals from the B cell antigen receptor. Reth, M., Wienands, J. Annu. Rev. Immunol. (1997)
- Impaired viability and profound block in thymocyte development in mice lacking the adaptor protein SLP-76. Pivniouk, V., Tsitsikov, E., Swinton, P., Rathbun, G., Alt, F.W., Geha, R.S. Cell (1998)
- T cell activation by clustered tyrosine kinases. Kolanus, W., Romeo, C., Seed, B. Cell (1993)
- Vav3 regulates osteoclast function and bone mass. Faccio, R., Teitelbaum, S.L., Fujikawa, K., Chappel, J., Zallone, A., Tybulewicz, V.L., Ross, F.P., Swat, W. Nat. Med. (2005)
- A chimeric human-cat fusion protein blocks cat-induced allergy. Zhu, D., Kepley, C.L., Zhang, K., Terada, T., Yamada, T., Saxon, A. Nat. Med. (2005)
- A critical role for Syk in signal transduction and phagocytosis mediated by Fcgamma receptors on macrophages. Crowley, M.T., Costello, P.S., Fitzer-Attas, C.J., Turner, M., Meng, F., Lowell, C., Tybulewicz, V.L., DeFranco, A.L. J. Exp. Med. (1997)
- Fcgamma receptor-mediated phagocytosis in macrophages lacking the Src family tyrosine kinases Hck, Fgr, and Lyn. Fitzer-Attas, C.J., Lowry, M., Crowley, M.T., Finn, A.J., Meng, F., DeFranco, A.L., Lowell, C.A. J. Exp. Med. (2000)
- The Src homology 2 domain of Vav is required for its compartmentation to the plasma membrane and activation of c-Jun NH(2)-terminal kinase 1. Arudchandran, R., Brown, M.J., Peirce, M.J., Song, J.S., Zhang, J., Siraganian, R.P., Blank, U., Rivera, J. J. Exp. Med. (2000)
- The carboxy-terminal region of the granulocyte colony-stimulating factor receptor transduces a phagocytic signal. Santini, V., Scappini, B., Indik, Z.K., Gozzini, A., Ferrini, P.R., Schreiber, A.D. Blood (2003)
- Cbl-b negatively regulates B cell antigen receptor signaling in mature B cells through ubiquitination of the tyrosine kinase Syk. Sohn, H.W., Gu, H., Pierce, S.K. J. Exp. Med. (2003)
- Lck regulates the tyrosine phosphorylation of the T cell receptor subunits and ZAP-70 in murine thymocytes. van Oers, N.S., Killeen, N., Weiss, A. J. Exp. Med. (1996)
- Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton. Obergfell, A., Eto, K., Mocsai, A., Buensuceso, C., Moores, S.L., Brugge, J.S., Lowell, C.A., Shattil, S.J. J. Cell Biol. (2002)
- Regulation of microtubule formation in activated mast cells by complexes of gamma-tubulin with Fyn and Syk kinases. Sulimenko, V., Dráberová, E., Sulimenko, T., Macurek, L., Richterová, V., Dráber, P., Dráber, P. J. Immunol. (2006)
- Kinase pathways in chemoattractant-induced degranulation of neutrophils: the role of p38 mitogen-activated protein kinase activated by Src family kinases. Mócsai, A., Jakus, Z., Vántus, T., Berton, G., Lowell, C.A., Ligeti, E. J. Immunol. (2000)
- Molecular basis for a direct interaction between the Syk protein-tyrosine kinase and phosphoinositide 3-kinase. Moon, K.D., Post, C.B., Durden, D.L., Zhou, Q., De, P., Harrison, M.L., Geahlen, R.L. J. Biol. Chem. (2005)
- Reconstitution of B cell antigen receptor-induced signaling events in a nonlymphoid cell line by expressing the Syk protein-tyrosine kinase. Richards, J.D., Gold, M.R., Hourihane, S.L., DeFranco, A.L., Matsuuchi, L. J. Biol. Chem. (1996)
- C-reactive protein suppresses insulin signaling in endothelial cells: role of spleen tyrosine kinase. Xu, J.W., Morita, I., Ikeda, K., Miki, T., Yamori, Y. Mol. Endocrinol. (2007)
- Granulocyte colony-stimulating factor receptor signaling involves the formation of a three-component complex with Lyn and Syk protein-tyrosine kinases. Corey, S.J., Burkhardt, A.L., Bolen, J.B., Geahlen, R.L., Tkatch, L.S., Tweardy, D.J. Proc. Natl. Acad. Sci. U.S.A. (1994)
- The pre-T cell receptor (TCR) complex is functionally coupled to the TCR-zeta subunit. van Oers, N.S., von Boehmer, H., Weiss, A. J. Exp. Med. (1995)
- Characterization of Cbl tyrosine phosphorylation and a Cbl-Syk complex in RBL-2H3 cells. Ota, Y., Beitz, L.O., Scharenberg, A.M., Donovan, J.A., Kinet, J.P., Samelson, L.E. J. Exp. Med. (1996)
- High dose M-CSF partially rescues the Dap12-/- osteoclast phenotype. Faccio, R., Zou, W., Colaianni, G., Teitelbaum, S.L., Ross, F.P. J. Cell. Biochem. (2003)
- Protein tyrosine kinase Syk in mast cell signaling. Siraganian, R.P., Zhang, J., Suzuki, K., Sada, K. Mol. Immunol. (2002)
- Antigen receptor proximal signaling in splenic B-2 cell subsets. Li, X., Martin, F., Oliver, A.M., Kearney, J.F., Carter, R.H. J. Immunol. (2001)
- Role for the Rac1 exchange factor Vav in the signaling pathways leading to NK cell cytotoxicity. Galandrini, R., Palmieri, G., Piccoli, M., Frati, L., Santoni, A. J. Immunol. (1999)
- Genetic and pharmacological analyses of involvement of Src-family, Syk and Btk tyrosine kinases in platelet shape change. Src-kinases mediate integrin alphaIIb beta3 inside-out signalling during shape change. Bauer, M., Maschberger, P., Quek, L., Briddon, S.J., Dash, D., Weiss, M., Watson, S.P., Siess, W. Thromb. Haemost. (2001)
- Regulation of protein kinase CbetaI by two protein-tyrosine kinases, Btk and Syk. Kawakami, Y., Kitaura, J., Hartman, S.E., Lowell, C.A., Siraganian, R.P., Kawakami, T. Proc. Natl. Acad. Sci. U.S.A. (2000)
- Direct T cell activation by chimeric single chain Fv-Syk promotes Syk-Cbl association and Cbl phosphorylation. Fitzer-Attas, C.J., Schindler, D.G., Waks, T., Eshhar, Z. J. Biol. Chem. (1997)
- Platelets activated by collagen through the immunoreceptor tyrosine-based activation motif in the Fc receptor gamma-chain play a pivotal role in the development of myocardial ischemia-reperfusion injury. Takaya, N., Katoh, Y., Iwabuchi, K., Hayashi, I., Konishi, H., Itoh, S., Okumura, K., Ra, C., Nagaoka, I., Daida, H. J. Mol. Cell. Cardiol. (2005)
- Rapid ubiquitination of Syk following GPVI activation in platelets. Dangelmaier, C.A., Quinter, P.G., Jin, J., Tsygankov, A.Y., Kunapuli, S.P., Daniel, J.L. Blood (2005)
- Lyn and Syk kinases are sequentially engaged in phagocytosis mediated by Fc gamma R. Strzelecka-Kiliszek, A., Kwiatkowska, K., Sobota, A. J. Immunol. (2002)
- Redundancy in B Cell Developmental Pathways: c-Cbl Inactivation Rescues Early B Cell Development through a B Cell Linker Protein-Independent Pathway. Song, H., Zhang, J., Chiang, Y.J., Siraganian, R.P., Hodes, R.J. J. Immunol. (2007)
- Scaffolding adapter Grb2-associated binder 2 requires Syk to transmit signals from FcepsilonRI. Yu, M., Lowell, C.A., Neel, B.G., Gu, H. J. Immunol. (2006)
- The SH2 domains of Src family kinases associate with Syk. Aoki, Y., Kim, Y.T., Stillwell, R., Kim, T.J., Pillai, S. J. Biol. Chem. (1995)
- Genetic and pharmacological analyses of Syk function in alphaIIbbeta3 signaling in platelets. Law, D.A., Nannizzi-Alaimo, L., Ministri, K., Hughes, P.E., Forsyth, J., Turner, M., Shattil, S.J., Ginsberg, M.H., Tybulewicz, V.L., Phillips, D.R. Blood (1999)
- Pre-T cell receptor signals are responsible for the down-regulation of Syk protein tyrosine kinase expression. Chu, D.H., van Oers, N.S., Malissen, M., Harris, J., Elder, M., Weiss, A. J. Immunol. (1999)
- Syk and Fyn are required by mouse megakaryocytes for the rise in intracellular calcium induced by a collagen-related peptide. Melford, S.K., Turner, M., Briddon, S.J., Tybulewicz, V.L., Watson, S.P. J. Biol. Chem. (1997)