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Gene Review

MTA2  -  metastasis associated 1 family, member 2

Homo sapiens

Synonyms: MTA1-L1, MTA1-L1 protein, MTA1L1, Metastasis-associated 1-like 1, Metastasis-associated protein MTA2, ...
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Disease relevance of MTA2


Psychiatry related information on MTA2


High impact information on MTA2

  • PID expression strongly represses p53-dependent transcriptional activation, and, notably, it modulates p53-mediated cell growth arrest and apoptosis [8].
  • MTA2 modulates the enzymatic activity of the histone deacetylase core complex [9].
  • MBD3 mediates the association of MTA2 with the core histone deacetylase complex [9].
  • We suggest that MTA1 associates with a different set of transcription factors from MTA2 and that this property may contribute to the metastatic potential of cells overexpressing MTA1 [1].
  • The superfamily is named PID (proliferation, ion, and death) because prohibitins are involved in proliferation and cell cycle control, stomatins are involved in ion channel regulation, and the plant defense-related genes are involved in cell death [10].

Chemical compound and disease context of MTA2

  • A five-fold increased risk of hospitalized pelvic infection among Dalkon Shield users found in the Women's Health Study resulted not from ascertainment bias, but was related to the fact that Dalkon Shield users had more severe hospitalized PID than did other hospitalized women with PID and IUD use [11].
  • The second model (PID) described the response in terms of a proportional component without delay, an integral component that adjusted basal delivery in proportion to hyper/hypoglycemia, and a derivative component that responded to the rate of glucose change [12].
  • The incidence of ectopic pregnancy has been steadily growing during the past decade; this fact can only partially be related to known factors (PID, use of IUDs, minipill, inductors of ovulation, sterilization reversal) [13].

Biological context of MTA2


Anatomical context of MTA2

  • The organism has also been isolated in the endometrium and fallopian tubes of women who have PID.The evidence is therefore accumulating that M genitalium is a cause of PID, and the assessment of reliable tests to further investigate the importance of this organism and its relevance in designing future treatment strategies is urgently needed [16].
  • Presuming that an increase in PID had a negative effect on metabolism of the intervertebral disc, our results may help to explain why progressive degeneration occurs in these segments [17].
  • We examined microbial isolates from the endocervical and peritoneal cavity of 30 women hospitalized with acute PID [18].
  • The GC positivity rates which were significantly higher than expected were found in patients with abnormal uterine bleeding, urinary tract symptoms, and cervicitis, as well as acute PID [19].
  • The GPC outperformed the MPC and PID controllers when applied to the cultivation of hybridoma cells [20].

Associations of MTA2 with chemical compounds

  • MTA1, MTA2, and MTA3 are components of the nucleosome remodeling and deacetylation complex, which is associated with adenosine triphosphate-dependent chromatin remodeling and transcriptional regulation [21].
  • Except for a transient increased risk after IUD insertions, increased risk is seen mainly in case-control studies after 1973, the time of a major PID epidemic and adverse publicity related to the Dalkon Shield [22].
  • Oxycodone 5 mg/ibuprofen 400 mg was significantly more effective compared with the other treatments on all secondary end points (P < 0.001, all variables except peak PID vs oxycodone 5 mg/acetaminophen 325 mg [P = 0.006]), with the exception of the time to onset of analgesia [23].
  • Whenever possible, women with PID should be hospitalized for parenteral therapy [24].
  • We conclude that it is appropriate in women with this stage of PID to treat initially with clindamycin and an aminoglycoside [25].

Physical interactions of MTA2


Other interactions of MTA2

  • MTA2 expression seems to be unrelated to ER status [26].

Analytical, diagnostic and therapeutic context of MTA2


  1. The metastasis-associated proteins 1 and 2 form distinct protein complexes with histone deacetylase activity. Yao, Y.L., Yang, W.M. J. Biol. Chem. (2003) [Pubmed]
  2. Metastasis-associated protein 2 is a repressor of estrogen receptor alpha whose overexpression leads to estrogen-independent growth of human breast cancer cells. Cui, Y., Niu, A., Pestell, R., Kumar, R., Curran, E.M., Liu, Y., Fuqua, S.A. Mol. Endocrinol. (2006) [Pubmed]
  3. Risk of pelvic inflammatory disease among intrauterine-device users irrespective of previous pregnancy. Osser, S., Gullberg, B., Liedholm, P., Sjöberg, N.O. Lancet (1980) [Pubmed]
  4. Hemophilus influenza infection of an implantable insulin-pump pocket. Levy, R.P., Borchelt, M.D., Kremer, R.M., Francis, S.J., O'Connor, C.A. Diabetes Care (1992) [Pubmed]
  5. The role of Neisseria gonorrhoeae and Chlamydia trachomatis in pelvic inflammatory disease and its sequelae in Zimbabwe. De Muylder, X., Laga, M., Tennstedt, C., Van Dyck, E., Aelbers, G.N., Piot, P. J. Infect. Dis. (1990) [Pubmed]
  6. Pelvic inflammatory disease and sepsis. Dulin, J.D., Akers, M.C. Critical care nursing clinics of North America. (2003) [Pubmed]
  7. Prions--infectious pathogens causing the spongiform encephalopathies. Prusiner, S.B., Kingsbury, D.T. CRC critical reviews in clinical neurobiology. (1985) [Pubmed]
  8. Deacetylation of p53 modulates its effect on cell growth and apoptosis. Luo, J., Su, F., Chen, D., Shiloh, A., Gu, W. Nature (2000) [Pubmed]
  9. Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation. Zhang, Y., Ng, H.H., Erdjument-Bromage, H., Tempst, P., Bird, A., Reinberg, D. Genes Dev. (1999) [Pubmed]
  10. Prohibitins, stomatins, and plant disease response genes compose a protein superfamily that controls cell proliferation, ion channel regulation, and death. Nadimpalli, R., Yalpani, N., Johal, G.S., Simmons, C.R. J. Biol. Chem. (2000) [Pubmed]
  11. Another look at the Dalkon Shield: meta-analysis underscores its problems. Sivin, I. Contraception. (1993) [Pubmed]
  12. Modeling beta-cell insulin secretion--implications for closed-loop glucose homeostasis. Steil, G.M., Rebrin, K., Janowski, R., Darwin, C., Saad, M.F. Diabetes Technol. Ther. (2003) [Pubmed]
  13. Biology of nidation and ectopic implantation. De Cecco, L., Capitanio, G.L., Croce, S., Forcucci, M., Gerbaldo, D., Rissone, R. Acta Eur. Fertil. (1984) [Pubmed]
  14. Molecular cloning, mapping, and characterization of a novel human gene, MTA1-L1, showing homology to a metastasis-associated gene, MTA1. Futamura, M., Nishimori, H., Shiratsuchi, T., Saji, S., Nakamura, Y., Tokino, T. J. Hum. Genet. (1999) [Pubmed]
  15. The regions of the Fe65 protein homologous to the phosphotyrosine interaction/phosphotyrosine binding domain of Shc bind the intracellular domain of the Alzheimer's amyloid precursor protein. Fiore, F., Zambrano, N., Minopoli, G., Donini, V., Duilio, A., Russo, T. J. Biol. Chem. (1995) [Pubmed]
  16. Is Mycoplasma genitalium a cause of pelvic inflammatory disease? Ross, J.D. Infect. Dis. Clin. North Am. (2005) [Pubmed]
  17. Intradiscal pressure recordings in the cervical spine. Pospiech, J., Stolke, D., Wilke, H.J., Claes, L.E. Neurosurgery (1999) [Pubmed]
  18. The microbiology and therapy of acute pelvic inflammatory disease in hospitalized patients. Thompson, S.E., Hager, W.D., Wong, K.H., Lopez, B., Ramsey, C., Allen, S.D., Stargel, M.D., Thornsberry, C., Benigno, B.B., Thompson, J.D., Shulman, J.A. Am. J. Obstet. Gynecol. (1980) [Pubmed]
  19. Female gonorrhea: its relation to abnormal uterine bleeding, urinary tract symptoms, and cervicitis. Curran, J.W., Rendtorff, R.C., Chandler, R.W., Wiser, W.L., Robinson, H. Obstetrics and gynecology. (1975) [Pubmed]
  20. Identification and control of dissolved oxygen in hybridoma cell culture in a shear sensitive environment. Simon, L., Karim, M.N. Biotechnol. Prog. (2001) [Pubmed]
  21. Emerging roles of MTA family members in human cancers. Kumar, R., Wang, R.A., Bagheri-Yarmand, R. Semin. Oncol. (2003) [Pubmed]
  22. Pelvic inflammatory disease with intrauterine device use: a reassessment. Kessel, E. Fertil. Steril. (1989) [Pubmed]
  23. Analgesic efficacy and tolerability of oxycodone 5 mg/ibuprofen 400 mg compared with those of oxycodone 5 mg/acetaminophen 325 mg and hydrocodone 7.5 mg/acetaminophen 500 mg in patients with moderate to severe postoperative pain: a randomized, double-blind, placebo-controlled, single-dose, parallel-group study in a dental pain model. Litkowski, L.J., Christensen, S.E., Adamson, D.N., Van Dyke, T., Han, S.H., Newman, K.B. Clinical therapeutics. (2005) [Pubmed]
  24. Pelvic inflammatory disease. Peterson, H.B., Galaid, E.I., Cates, W. Med. Clin. North Am. (1990) [Pubmed]
  25. Reproductive outcome after medical management of complicated pelvic inflammatory disease. Brumsted, J.R., Clifford, P.M., Nakajima, S.T., Gibson, M. Fertil. Steril. (1988) [Pubmed]
  26. Metastasis tumor antigen family proteins during breast cancer progression and metastasis in a reliable mouse model for human breast cancer. Zhang, H., Stephens, L.C., Kumar, R. Clin. Cancer Res. (2006) [Pubmed]
  27. Sexually transmitted diseases and infertility. Weström, L.V. Sexually transmitted diseases. (1994) [Pubmed]
  28. Pattern of acute pelvic inflammatory disease in abortion-related admissions. Sinnathuray, T.A., Yusof, K., Palan, V.T., Fong, C.K., Adeep, N., Chong, C.H., Yip, Y.C. Am. J. Obstet. Gynecol. (1980) [Pubmed]
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