The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

DPP10  -  dipeptidyl-peptidase 10 (non-functional)

Homo sapiens

Synonyms: DPL2, DPP X, DPPY, DPRP-3, DPRP3, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on DPP10

  • SNP association was limited to the initial exons of a solitary gene of 3.6 kb (DPP10), which extends over 1 Mb of genomic DNA [1].
  • In 2003, two novel genes relating to asthma were identified using this approach, PHF11 and DPP10, neither of which had previously been implicated in the pathobiology of either asthma or allergy [2].
  • Evidence for selective sweeps is also found in many other regions, including genes known to be associated with disease risk such as DPP10 and COL4A3 [3].
  • We found DPP10 activity to be nearly identical to DPPX activity and significantly different from DPPIV activity [4].
  • These experiments suggest that DPP10 contributes to the molecular composition of A-type currents in the central nervous system [4].

Biological context of DPP10


Anatomical context of DPP10

  • Northern-blot analysis shows that whereas DPP8 and DPP9 are widely expressed, DPP10 is expressed mainly in the brain and pancreas [5].
  • Kv4.2 coimmunoprecipitated with HA/DPP10 from extracts of oocytes heterologously expressing both proteins [7].
  • DPP10 mRNA is abundantly expressed in nodose and dorsal root ganglia, suggesting that DPP10 participates in controlling airway reactivity and mechanosensation [8].
  • Here we report that DPPY mRNA is abundant in human adrenal gland, but very low in the corresponding rat tissue [9].

Associations of DPP10 with chemical compounds

  • We propose that DPP10 is a new member of the S9B serine proteases subfamily [5].
  • The substrate AdoMet adopts a bent shape that directs the activated methyl group toward the active site near the catalytic DPPY motif [10].
  • The IgVL/lambda genes belonged to the Vlambda1 family (DPL2, DPL5, DPL8nf), the Vlambda2 family (DPL11, n = 2) and to the Vlambda6 family (IGLV6S1); 6/6 IgVL genes showed somatic mutations, the R/S ratio (CDR) was > 3 in 3/6 IgVL genes and the mean R/S ratio of all IgVL was 3.0 (CDR) and 2.3 (FR), suggesting an antigen-dependent selection [11].

Other interactions of DPP10

  • DPP6, which has the highest amino acid identity with DPP10, has been shown previously [Nadal, Ozaita, Amarillo, de Miera, Ma, Mo, Goldberg, Misumi, Ikehara, Neubert et al. (2003) Neuron 37, 449-461] to associate with A-type K(+) channel subunits, modulating their transport and function in somatodendritic compartments of neurons [5].
  • Elucidation of the physiological or pathophysiological role of DPP8, DPP9 and DPP10 and characterization of their structure-function relationships will add impetus to the development of inhibitor molecules for pharmacological or therapeutic use [5].
  • DPP10 expressed with Kv4.3 caused negative shifts in both steady-state activation and inactivation of Kv4.3, but no significant shifts were detected when DPP10 was expressed with Kv4.3 + KChIP2b (Kv channel interacting protein) [12].
  • Finally, significant progress in the field of asthma heritability is featured in reports relating to both known and novel genes, including those encoding CCR5 and DPP-10 [13].

Analytical, diagnostic and therapeutic context of DPP10

  • Using in situ hybridization, we found DPP10 to be prominently expressed in brain neuronal populations that also express Kv4 subunits [4].
  • Sequence analysis showed that the V lambda segment of the AC6C3 MAb had 80.29% homology to the human germline Ig lambda-chain V lambda III.1, clone DPL2 [14].


  1. Positional cloning of a novel gene influencing asthma from chromosome 2q14. Allen, M., Heinzmann, A., Noguchi, E., Abecasis, G., Broxholme, J., Ponting, C.P., Bhattacharyya, S., Tinsley, J., Zhang, Y., Holt, R., Jones, E.Y., Lench, N., Carey, A., Jones, H., Dickens, N.J., Dimon, C., Nicholls, R., Baker, C., Xue, L., Townsend, E., Kabesch, M., Weiland, S.K., Carr, D., von Mutius, E., Adcock, I.M., Barnes, P.J., Lathrop, G.M., Edwards, M., Moffatt, M.F., Cookson, W.O. Nat. Genet. (2003) [Pubmed]
  2. Asthma genetics 2003. Weiss, S.T., Raby, B.A. Hum. Mol. Genet. (2004) [Pubmed]
  3. Genomic scans for selective sweeps using SNP data. Nielsen, R., Williamson, S., Kim, Y., Hubisz, M.J., Clark, A.G., Bustamante, C. Genome Res. (2005) [Pubmed]
  4. DPP10 modulates Kv4-mediated A-type potassium channels. Zagha, E., Ozaita, A., Chang, S.Y., Nadal, M.S., Lin, U., Saganich, M.J., McCormack, T., Akinsanya, K.O., Qi, S.Y., Rudy, B. J. Biol. Chem. (2005) [Pubmed]
  5. Cloning and characterization of dipeptidyl peptidase 10, a new member of an emerging subgroup of serine proteases. Qi, S.Y., Riviere, P.J., Trojnar, J., Junien, J.L., Akinsanya, K.O. Biochem. J. (2003) [Pubmed]
  6. Functional analysis of conserved motifs in type III restriction-modification enzymes. Saha, S., Ahmad, I., Reddy, Y.V., Krishnamurthy, V., Rao, D.N. Biol. Chem. (1998) [Pubmed]
  7. Modulation of Kv4.2 channel expression and gating by dipeptidyl peptidase 10 (DPP10). Jerng, H.H., Qian, Y., Pfaffinger, P.J. Biophys. J. (2004) [Pubmed]
  8. Transmembrane interaction mediates complex formation between peptidase homologues and Kv4 channels. Ren, X., Hayashi, Y., Yoshimura, N., Takimoto, K. Mol. Cell. Neurosci. (2005) [Pubmed]
  9. Species and tissue differences in the expression of DPPY splicing variants. Takimoto, K., Hayashi, Y., Ren, X., Yoshimura, N. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  10. Structures of liganded and unliganded RsrI N6-adenine DNA methyltransferase: a distinct orientation for active cofactor binding. Thomas, C.B., Scavetta, R.D., Gumport, R.I., Churchill, M.E. J. Biol. Chem. (2003) [Pubmed]
  11. Molecular analysis of rheumatoid factor (RF)-negative B cell hybridomas from rheumatoid synovial tissue: evidence for an antigen-induced stimulation with selection of high mutated IgVH and low mutated IgVL/lambda genes. Krenn, V., König, A., Hensel, F., Berek, C., Souto Carneiro, M.M., Haedicke, W., Wang, Y., Vollmers, H., Müller-Hermelink, H.K. Clin. Exp. Immunol. (1999) [Pubmed]
  12. DPP10 is an inactivation modulatory protein of Kv4.3 and Kv1.4. Li, H.L., Qu, Y.J., Lu, Y.C., Bondarenko, V.E., Wang, S., Skerrett, I.M., Morales, M.J. Am. J. Physiol., Cell Physiol. (2006) [Pubmed]
  13. Chemokines and their receptors in the pathogenesis of allergic asthma: progress and perspective. Bisset, L.R., Schmid-Grendelmeier, P. Current opinion in pulmonary medicine. (2005) [Pubmed]
  14. Amplification of immunoglobulin transcripts by the non-palindromic adaptor polymerase chain reaction (NPA-PCR). Nucleotide sequence analysis of two human monoclonal antibodies recognizing two cell surface antigens expressed in ovarian, cervix, breast, colon and other carcinomas. Chen, P.F., Freedman, R.S., Chernajovsky, Y., Platsoucas, C.D. Hum. Antibodies Hybridomas (1994) [Pubmed]
WikiGenes - Universities