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PTPN14  -  protein tyrosine phosphatase, non-receptor...

Homo sapiens

Synonyms: PEZ, PTP36, PTPD2, Protein-tyrosine phosphatase pez, Tyrosine-protein phosphatase non-receptor type 14
 
 
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High impact information on PTPN14

 

Biological context of PTPN14

 

Anatomical context of PTPN14

 

Associations of PTPN14 with chemical compounds

  • Crystal structure of human protein tyrosine phosphatase 14 (PTPN14) at 1.65-A resolution [5].
  • PTP36 was found to make complexes with serine/threonine kinase(s), which phosphorylated PTP36 in vitro [2].
  • Further studies using deletion mutants suggested that the first 30 amino acids as well as the band 4.1 domain of PTP36 were involved in association with Triton X-100 insoluble cytoskeletons [6].
  • We compare PEZ with inorganic phosphate-modified zirconia to show increased efficiency, as well as unique selectivities for chromatography of proteins on the chelator-modified surface [7].
 

Other interactions of PTPN14

 

Analytical, diagnostic and therapeutic context of PTPN14

  • Further detailed RT-PCR and Northern blot analyses revealed the expression of several isoforms for PTP36 in a tissue-dependent manner [6].

References

  1. The protein tyrosine phosphatase Pez is a major phosphatase of adherens junctions and dephosphorylates beta-catenin. Wadham, C., Gamble, J.R., Vadas, M.A., Khew-Goodall, Y. Mol. Biol. Cell (2003) [Pubmed]
  2. Regulation of phosphorylation level and distribution of PTP36, a putative protein tyrosine phosphatase, by cell-substrate adhesion. Ogata, M., Takada, T., Mori, Y., Uchida, Y., Miki, T., Okuyama, A., Kosugi, A., Sawada, M., Oh-hora, M., Hamaoka, T. J. Biol. Chem. (1999) [Pubmed]
  3. Effects of overexpression of PTP36, a putative protein tyrosine phosphatase, on cell adhesion, cell growth, and cytoskeletons in HeLa cells. Ogata, M., Takada, T., Mori, Y., Oh-hora, M., Uchida, Y., Kosugi, A., Miyake, K., Hamaoka, T. J. Biol. Chem. (1999) [Pubmed]
  4. Translocation of protein tyrosine phosphatase Pez/PTPD2/PTP36 to the nucleus is associated with induction of cell proliferation. Wadham, C., Gamble, J.R., Vadas, M.A., Khew-Goodall, Y. J. Cell. Sci. (2000) [Pubmed]
  5. Crystal structure of human protein tyrosine phosphatase 14 (PTPN14) at 1.65-A resolution. Barr, A.J., Debreczeni, J.E., Eswaran, J., Knapp, S. Proteins (2006) [Pubmed]
  6. Characterization of newly identified four isoforms for a putative cytosolic protein tyrosine phosphatase PTP36. Aoyama, K., Matsuda, T., Aoki, N. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
  7. Chromatographic characterization of phosphonate analog EDTA-modified zirconia support for biochromatographic applications. Clausen, A.M., Carr, P.W. Anal. Chem. (1998) [Pubmed]
  8. Comparative analysis of the Band 4.1/ezrin-related protein tyrosine phosphatase Pez from two Drosophila species: implications for structure and function. Edwards, K., Davis, T., Marcey, D., Kurihara, J., Yamamoto, D. Gene (2001) [Pubmed]
 
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