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Chemical Compound Review

Rhuligel     dioxozirconium

Synonyms: Zirconia, ZrO2, Norton 9839, Zircoa 5027, TZ 3YTSK, ...
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Disease relevance of dioxozirconium

  • Using this new zirconia-based phase, a purification protocol is developed for the efficient removal of Escherichia coli 0111:B4 LPS from bovine insulin samples [1].
  • Recovery of leukoregulin proliferation inhibitory activity directed against RPMI 2650 epidermoid carcinoma cells was 90% from the silica, 88% from the agarose and 35% from the zirconia stabilized silica columns [2].
  • Of 12 hips with acetabular osteolysis, six had a 28 mm cobalt-chrome femoral head and the remaining six a 28 mm zirconia head [3].
  • However, under severe microseparation conditions representative of greater joint laxity, the wear rate of zirconia against alumina increased by 2 orders of magnitude, producing severe wear and, in one case, femoral head fracture [4].
  • MATERIAL AND METHODS: Thirty pulpless teeth in 22 patients were treated with zirconia posts [5].

High impact information on dioxozirconium

  • In the absence of these ions, the exopolyphosphatase binds to polyphosphate but does not degrade it, allowing affinity purification of the enzyme on a polyphosphate-modified zirconia support. o-Vanadate, Cu2+, and Ca2+ are effective inhibitors of the exopolyphosphatase [6].
  • In situ solid-state NMR spectroscopy was employed to study the kinetics of hydrogen/deuterium exchange and scrambling as well as (13)C scrambling reactions of labeled propane over Al(2)O(3)-promoted sulfated zirconia (SZA) catalyst under mild conditions (30-102 degrees C) [7].
  • Hydrodynamic flow and electroosmotic flow in zirconia-packed capillaries [8].
  • As for native zirconia, the EOF is pH-dependent and the pI is close to pH 5 [8].
  • In zirconia-coated capillaries the zeta-potential can be tuned from -50 to +100 mV depending on the composition of the electrolyte [9].

Chemical compound and disease context of dioxozirconium


Biological context of dioxozirconium

  • A highly active and stable zirconia supported 12-tungstophosphoric acid catalyst is found to be 2-3 times more active in benzylation and acylation reactions than a tungstated zirconia catalyst [11].
  • Lifetime "nose-only" inhalation studies were conducted in rats using four types of refractory ceramic fibers (FCF), 1 micron in diameter x 22 to 26 microns length: High Purity, Kaolin, Zirconia, and After-Service; and on hamsters using Kaolin RCF [12].
  • The biocompatibility and osseointegration of zirconia (ZrO(2)), either coated with RKKP bioglazeor uncoated, were evaluated in vitro and in vivo [13].
  • The utilisation of organosilanes to introduce active chemical groups onto zirconia surfaces, suitable for the subsequent immobilisation of proteins or other biomimetic ligands, is described [14].
  • Zirconia-based column high-performance liquid chromatography/atmospheric pressure photoionization tandem mass spectrometric analyses of drug molecules in rat plasma [15].

Anatomical context of dioxozirconium


Associations of dioxozirconium with other chemical compounds


Gene context of dioxozirconium

  • Furthermore, MMP-2 mRNA expression was decreased by titanium and increased by alumina whereas zirconia did not have any significant effect [25].
  • Conversely, MMP-9 mRNA expression was stimulated by titanium but decreased with zirconia, whereas alumina induced no significant changes [25].
  • First either mycobacterial primary transformants or propagated cultures were lysed in a mini-bead beater using zirconia beads and the lysate thus obtained was used to transform E. coli recA mutant cells [26].
  • We compare PEZ with inorganic phosphate-modified zirconia to show increased efficiency, as well as unique selectivities for chromatography of proteins on the chelator-modified surface [27].
  • However, this is at the expense of a portion of the two-dimensional peak capacity displayed by the C18-carbon clad zirconia system [28].

Analytical, diagnostic and therapeutic context of dioxozirconium


  1. The efficient removal of endotoxins from insulin using quaternized polyethyleneimine-coated porous zirconia. McNeff, C., Zhao, Q., Almlöf, E., Flickinger, M., Carr, P.W. Anal. Biochem. (1999) [Pubmed]
  2. Comparative chromatography of lectins and bioactivity recovery of the immunologic hormone leukoregulin on derivatized silica and on cross-linked agarose molecular sizing high-performance liquid chromatographic matrices. Evans, C.H., Barnett, S.C. J. Chromatogr. (1987) [Pubmed]
  3. A comparison of polyethylene wear in hips with cobalt-chrome or zirconia heads. A prospective, randomised study. Kim, Y.H., Kim, J.S., Cho, S.H. The Journal of bone and joint surgery. British volume. (2001) [Pubmed]
  4. Severe wear and fracture of zirconia heads against alumina inserts in hip simulator studies with microseparation. Stewart, T.D., Tipper, J.L., Insley, G., Streicher, R.M., Ingham, E., Fisher, J. The Journal of arthroplasty. (2003) [Pubmed]
  5. Clinical evaluation of pulpless teeth restored with conventionally cemented zirconia posts: a pilot study. Nothdurft, F.P., Pospiech, P.R. The Journal of prosthetic dentistry. (2006) [Pubmed]
  6. Purification and characterization of an exopolyphosphatase from Saccharomyces cerevisiae. Lorenz, B., Müller, W.E., Kulaev, I.S., Schröder, H.C. J. Biol. Chem. (1994) [Pubmed]
  7. The initial stages of solid acid-catalyzed reactions of adsorbed propane. A mechanistic study by in situ MAS NMR. Haouas, M., Walspurger, S., Taulelle, F., Sommer, J. J. Am. Chem. Soc. (2004) [Pubmed]
  8. Hydrodynamic flow and electroosmotic flow in zirconia-packed capillaries. Crosnier de Bellaistre, M., Randon, J., Rocca, J.L. Electrophoresis (2006) [Pubmed]
  9. Streaming current measurements in zirconia-coated capillaries. Crosnier de Bellaistre, M., Renaud, L., Kleimann, P., Morin, P., Randon, J., Rocca, J.L. Electrophoresis (2004) [Pubmed]
  10. Induction of malignant fibrous histiocytoma in female Fisher rats by implantation of cyanoacrylate, zirconia, polyvinyl chloride or silicone. Hatanaka, S., Oneda, S., Okazaki, K., Shong, L.J., Yoshida, A., Isaka, H., Yoshida, H. In Vivo (1993) [Pubmed]
  11. 12-Tungstophosphoric acid/zirconia--a highly active stable solid acid--comparison with a tungstated zirconia catalyst. Devassy, B.M., Halligudi, S.B., Hegde, S.G., Halgeri, A.B., Lefebvre, F. Chem. Commun. (Camb.) (2002) [Pubmed]
  12. Chronic inhalation and biopersistence of refractory ceramic fiber in rats and hamsters. Mast, R.W., Hesterberg, T.W., Glass, L.R., McConnell, E.E., Anderson, R., Bernstein, D.M. Environ. Health Perspect. (1994) [Pubmed]
  13. Improvement in zirconia osseointegration by means of a biological glass coating: An in vitro and in vivo investigation. Aldini, N.N., Fini, M., Giavaresi, G., Torricelli, P., Martini, L., Giardino, R., Ravaglioli, A., Krajewski, A., Mazzocchi, M., Dubini, B., Ponzi-Bossi, M.G., Rustichelli, F., Stanic, V. J. Biomed. Mater. Res. (2002) [Pubmed]
  14. High-performance liquid chromatography of amino acids, peptides and proteins. CXXX. Modified porous zirconia as sorbents in affinity chromatography. Wirth, H.J., Hearn, M.T. J. Chromatogr. (1993) [Pubmed]
  15. Zirconia-based column high-performance liquid chromatography/atmospheric pressure photoionization tandem mass spectrometric analyses of drug molecules in rat plasma. Hsieh, Y., Merkle, K., Wang, G. Rapid Commun. Mass Spectrom. (2003) [Pubmed]
  16. Ceramic and PMMA particles differentially affect osteoblast phenotype. Lohmann, C.H., Dean, D.D., Köster, G., Casasola, D., Buchhorn, G.H., Fink, U., Schwartz, Z., Boyan, B.D. Biomaterials (2002) [Pubmed]
  17. Raman spectroscopic analysis of phase-transformation and stress patterns in zirconia hip joints. Pezzotti, G., Porporati, A.A. Journal of biomedical optics. (2004) [Pubmed]
  18. Activity of plasma sprayed yttria stabilized zirconia reinforced hydroxyapatite/Ti-6Al-4V composite coatings in simulated body fluid. Gu, Y.W., Khor, K.A., Pan, D., Cheang, P. Biomaterials (2004) [Pubmed]
  19. In vitro reactions of human osteoblasts in culture with zirconia and alumina ceramics. Josset, Y., Oum'Hamed, Z., Zarrinpour, A., Lorenzato, M., Adnet, J.J., Laurent-Maquin, D. J. Biomed. Mater. Res. (1999) [Pubmed]
  20. Biological reaction to alumina, zirconia, titanium and polyethylene particles implanted onto murine calvaria. Warashina, H., Sakano, S., Kitamura, S., Yamauchi, K.I., Yamaguchi, J., Ishiguro, N., Hasegawa, Y. Biomaterials (2003) [Pubmed]
  21. A comparative study of the chromatographic selectivity of polystyrene-coated zirconia and related reversed-phase materials. Zhao, J., Carr, P.W. Anal. Chem. (2000) [Pubmed]
  22. Development of an eluotropic series for the chromatography of Lewis bases on zirconium oxide. Blackwell, J.A., Carr, P.W. Anal. Chem. (1992) [Pubmed]
  23. Synthesis and evaluation of an aromatic polymer-coated zirconia for reversed-phase liquid chromatography. Zhao, J., Carr, P.W. Anal. Chem. (1999) [Pubmed]
  24. Growth hormone covalently bound to sepharose or glass. Analysis of ligand release rates and characterization of soluble radiolabeled products. Bolander, F.F., Fellows, R.E. Biochemistry (1975) [Pubmed]
  25. Matrix metalloproteinases MMP-2, -9 and tissue inhibitors TIMP-1, -2 expression and secretion by primary human osteoblast cells in response to titanium, zirconia, and alumina ceramics. Oum'hamed, Z., Garnotel, R., Josset, Y., Trenteseaux, C., Laurent-Maquin, D. Journal of biomedical materials research. Part A. (2004) [Pubmed]
  26. Development of simple and efficient protocol for isolation of plasmids from mycobacteria using zirconia beads. Madiraju, M.V., Qin, M.H., Rajagopalan, M. Lett. Appl. Microbiol. (2000) [Pubmed]
  27. Chromatographic characterization of phosphonate analog EDTA-modified zirconia support for biochromatographic applications. Clausen, A.M., Carr, P.W. Anal. Chem. (1998) [Pubmed]
  28. Utilising retention correlation for the separation of oligostyrenes by coupled-column liquid chromatography. Gray, M.J., Dennis, G.R., Slonecker, P.J., Shalliker, R.A. Journal of chromatography. A. (2005) [Pubmed]
  29. Neutron diffraction study of the size-induced tetragonal to monoclinic phase transition in zirconia nanocrystals. Baldinozzi, G., Simeone, D., Gosset, D., Dutheil, M. Phys. Rev. Lett. (2003) [Pubmed]
  30. Synthesis and characterization of new zirconia-based polymeric cation-exchange stationary phases for high-performance liquid chromatography of proteins. Hu, Y., Carr, P.W. Anal. Chem. (1998) [Pubmed]
  31. Intermolecular interactions involved in solute retention on carbon media in reversed-phase high-performance liquid chromatography. Jackson, P.T., Schure, M.R., Weber, T.P., Carr, P.W. Anal. Chem. (1997) [Pubmed]
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