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Slc28a2  -  solute carrier family 28 (concentrative...

Rattus norvegicus

Synonyms: CNT 2, Cnt2, Concentrative nucleoside transporter 2, Na(+)/nucleoside cotransporter 2, SPNT, ...
 
 
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Disease relevance of Slc28a2

 

Psychiatry related information on Slc28a2

  • This specific decrease in CNT2 transcript suggests a new physiological role for the transporter in the modulation of extracellular adenosine levels and the sleep/wakefulness cycle [2].
 

High impact information on Slc28a2

  • BACKGROUND & AIMS: Concentrative nucleoside transporters CNT1 (pyrimidine preferring) and CNT2 (purine preferring) may be involved in the uptake of nucleoside-derived drugs used in antiviral and chemical therapies [3].
  • This study describes a novel mechanism of regulation of the high-affinity Na(+)-dependent adenosine transporter (CNT2) via the activation of A(1) adenosine receptors (A(1)R) [1].
  • With the available antibodies against Kir6.X, SUR2A, and SUR2B, it is shown that all of these proteins colocalize with CNT2 and A(1)R in defined plasma membrane domains of FAO cells [1].
  • The extent of the purinergic modulation of CNT2 is affected by the glucose concentration, a finding which indicates that glycemia and glucose metabolism may affect this cross-regulation among A(1)R, CNT2, and K(ATP) channels [1].
  • A(1)R agonist activation of CNT2 occurs in both hepatocytes and FAO cells, which express Kir6.1, Kir6.2, SUR1, SUR2A, and SUR2B mRNA channel subunits [1].
 

Biological context of Slc28a2

 

Anatomical context of Slc28a2

  • Cloned blood-brain barrier adenosine transporter is identical to the rat concentrative Na+ nucleoside cotransporter CNT2 [5].
  • CNT2 mRNA was widespread in rat brain, although most prevalent in the amygdala, the hippocampus, specific neocortical regions and the cerebellum [2].
  • In this study, we analysed the distribution of the transcript encoding the high affinity adenosine-preferring concentrative transporter CNT2 in the rat central nervous system and compared it with that of the equilibrative transporter ENT1 [2].
  • Distribution of CNT2 and ENT1 transcripts in rat brain: selective decrease of CNT2 mRNA in the cerebral cortex of sleep-deprived rats [2].
  • 6. Rat skeletal muscle MVECs express es/ENT1, ei/ENT2, and cif/CNT2 transporters with characteristics typical of rat tissues [8].
 

Associations of Slc28a2 with chemical compounds

  • Incubation of fetal hepatocytes with dexamethasone and T3 resulted in a significant increase in Na+-dependent uridine uptake and an accumulation of the CNT2 protein and mRNA [7].
  • Expression of concentrative nucleoside transporters SLC28 (CNT1, CNT2, and CNT3) along the rat nephron: effect of diabetes [6].
 

Analytical, diagnostic and therapeutic context of Slc28a2

  • The cellular expression of equilibrative (ENT1, ENT2, ENT3) and concentrative (CNT1, CNT2, CNT3) NT subtypes was also determined using both qualitative and quantitative polymerase chain reaction techniques [8].
  • SPNT mRNA amounts increased as early as 2 hours after partial hepatectomy [9].
  • A PCR-generated fragment, based on a published SPNT sequence cloned from rat liver, was used as a probe in Northern blot analysis [10].

References

  1. ATP-sensitive K(+) channels regulate the concentrative adenosine transporter CNT2 following activation by A(1) adenosine receptors. Duflot, S., Riera, B., Fernández-Veledo, S., Casadó, V., Norman, R.I., Casado, F.J., Lluís, C., Franco, R., Pastor-Anglada, M. Mol. Cell. Biol. (2004) [Pubmed]
  2. Distribution of CNT2 and ENT1 transcripts in rat brain: selective decrease of CNT2 mRNA in the cerebral cortex of sleep-deprived rats. Guillén-Gómez, E., Calbet, M., Casado, J., de Lecea, L., Soriano, E., Pastor-Anglada, M., Burgaya, F. J. Neurochem. (2004) [Pubmed]
  3. Nutritional regulation of nucleoside transporter expression in rat small intestine. Valdés, R., Ortega, M.A., Casado, F.J., Felipe, A., Gil, A., Sánchez-Pozo, A., Pastor-Anglada, M. Gastroenterology (2000) [Pubmed]
  4. Selective loss of nucleoside carrier expression in rat hepatocarcinomas. Dragan, Y., Valdés, R., Gomez-Angelats, M., Felipe, A., Javier Casado, F., Pitot, H., Pastor-Anglada, M. Hepatology (2000) [Pubmed]
  5. Cloned blood-brain barrier adenosine transporter is identical to the rat concentrative Na+ nucleoside cotransporter CNT2. Li, J.Y., Boado, R.J., Pardridge, W.M. J. Cereb. Blood Flow Metab. (2001) [Pubmed]
  6. Expression of concentrative nucleoside transporters SLC28 (CNT1, CNT2, and CNT3) along the rat nephron: effect of diabetes. Rodríguez-Mulero, S., Errasti-Murugarren, E., Ballarín, J., Felipe, A., Doucet, A., Casado, F.J., Pastor-Anglada, M. Kidney Int. (2005) [Pubmed]
  7. Developmental regulation of the concentrative nucleoside transporters CNT1 and CNT2 in rat liver. del Santo, B., Tarafa, G., Felipe, A., Casado, F.J., Pastor-Anglada, M. J. Hepatol. (2001) [Pubmed]
  8. Nucleoside transporter subtype expression and function in rat skeletal muscle microvascular endothelial cells. Archer, R.G., Pitelka, V., Hammond, J.R. Br. J. Pharmacol. (2004) [Pubmed]
  9. Differential expression and regulation of nucleoside transport systems in rat liver parenchymal and hepatoma cells. del Santo, B., Valdés, R., Mata, J., Felipe, A., Casado, F.J., Pastor-Anglada, M. Hepatology (1998) [Pubmed]
  10. Expression of sodium-dependent purine nucleoside carrier (SPNT) mRNA correlates with nucleoside transport activity in rat liver. Felipe, A., Ferrer-Martínez, A., Casado, F.J., Pastor-Anglada, M. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
 
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