The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

SLC28A2  -  solute carrier family 28 (concentrative...

Homo sapiens

Synonyms: CNT 2, CNT2, Concentrative nucleoside transporter 2, HCNT2, HsT17153, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of SLC28A2

  • Both proteins belong to a gene family that includes the NupC proton/nucleoside symporter of E. coli. cDNAs encoding members of the CNT family have been isolated from rat tissues (jejunum, brain, liver; rCNT1 and rCNT2/SPNT) and, most recently, human kidney (hCNT1 and hSPNT1) [1].
  • Bacterial isolates, namely Rhodococcus (HCCS), Sphingomonas (MWFG) and Paracoccus (SPNT) were capable to degrade mixed PAHs (Phe + Fla + Pyr) [2].

High impact information on SLC28A2

  • RESULTS: Gemcitabine was transported by most of the tested proteins (the exceptions being the purine-selective rCNT2 and hCNT2), with the greatest uptake occurring in oocytes producing recombinant rCNT1 and hCNT1 [3].
  • Despite a huge individual variability in the mRNA amounts for every transporter gene expressed in CLL cells (CNT2, CNT3, ENT1, and ENT2), no relationship between mRNA levels and in vitro fludarabine cytotoxicity was observed [4].
  • CNT2 proteins, the high-affinity transporters for purines like adenosine as well as for uridine, have been found in cells comprising the BBB of rats [5].
  • Moreover, inhibition of adenosine transport through the concentrative adenosine plasma membrane transporter CNT2 with formycin B results in the blockade of adenosine-mediated AMPK signaling [6].
  • These models reveal that hCNT2 affinity is dominated by hydrogen bonding features, whereas hCNT1 and hENT1 displayed mainly electrostatic and steric features [7].

Biological context of SLC28A2


Anatomical context of SLC28A2


Associations of SLC28A2 with chemical compounds


Regulatory relationships of SLC28A2

  • TGF-beta transcriptionally activates the gene encoding the high-affinity adenosine transporter CNT2 in rat liver parenchymal cells [14].


  1. Molecular cloning, functional expression and chromosomal localization of a cDNA encoding a human Na+/nucleoside cotransporter (hCNT2) selective for purine nucleosides and uridine. Ritzel, M.W., Yao, S.Y., Ng, A.M., Mackey, J.R., Cass, C.E., Young, J.D. Mol. Membr. Biol. (1998) [Pubmed]
  2. Isolation of PAH-degrading bacteria from mangrove sediments and their biodegradation potential. Guo, C.L., Zhou, H.W., Wong, Y.S., Tam, N.F. Mar. Pollut. Bull. (2005) [Pubmed]
  3. Gemcitabine transport in xenopus oocytes expressing recombinant plasma membrane mammalian nucleoside transporters. Mackey, J.R., Yao, S.Y., Smith, K.M., Karpinski, E., Baldwin, S.A., Cass, C.E., Young, J.D. J. Natl. Cancer Inst. (1999) [Pubmed]
  4. Fludarabine uptake mechanisms in B-cell chronic lymphocytic leukemia. Molina-Arcas, M., Bellosillo, B., Casado, F.J., Montserrat, E., Gil, J., Colomer, D., Pastor-Anglada, M. Blood (2003) [Pubmed]
  5. Uridine and cytidine in the brain: their transport and utilization. Cansev, M. Brain Res. Brain Res. Rev. (2006) [Pubmed]
  6. Extracellular adenosine activates AMP-dependent protein kinase (AMPK). Aymerich, I., Foufelle, F., Ferré, P., Casado, F.J., Pastor-Anglada, M. J. Cell. Sci. (2006) [Pubmed]
  7. Molecular requirements of the human nucleoside transporters hCNT1, hCNT2, and hENT1. Chang, C., Swaan, P.W., Ngo, L.Y., Lum, P.Y., Patil, S.D., Unadkat, J.D. Mol. Pharmacol. (2004) [Pubmed]
  8. Transcription factors involved in the expression of SLC28 genes in human liver parenchymal cells. Fern??ndez-Veledo, S., Jover, R., Casado, F.J., G??mez-Lech??n, M.J., Pastor-Anglada, M. Biochem. Biophys. Res. Commun. (2007) [Pubmed]
  9. Specific Mutations in Transmembrane Helix 8 of Human Concentrative Na(+)/Nucleoside Cotransporter hCNT1 Affect Permeant Selectivity and Cation Coupling. Slugoski, M.D., Loewen, S.K., Ng, A.M., Smith, K.M., Yao, S.Y., Karpinski, E., Cass, C.E., Baldwin, S.A., Young, J.D. Biochemistry (2007) [Pubmed]
  10. Identification of amino acid residues responsible for the pyrimidine and purine nucleoside specificities of human concentrative Na(+) nucleoside cotransporters hCNT1 and hCNT2. Loewen, S.K., Ng, A.M., Yao, S.Y., Cass, C.E., Baldwin, S.A., Young, J.D. J. Biol. Chem. (1999) [Pubmed]
  11. Functional expression and characterization of a sodium-dependent nucleoside transporter hCNT2 cloned from human duodenum. Shin, H.C., Landowski, C.P., Sun, D., Vig, B.S., Kim, I., Mittal, S., Lane, M., Rosania, G., Drach, J.C., Amidon, G.L. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  12. Ribavirin uptake by cultured human choriocarcinoma (BeWo) cells and Xenopus laevis oocytes expressing recombinant plasma membrane human nucleoside transporters. Yamamoto, T., Kuniki, K., Takekuma, Y., Hirano, T., Iseki, K., Sugawara, M. Eur. J. Pharmacol. (2007) [Pubmed]
  13. Specificity of human and rat orthologs of the concentrative nucleoside transporter, SPNT. Gerstin, K.M., Dresser, M.J., Giacomini, K.M. Am. J. Physiol. Renal Physiol. (2002) [Pubmed]
  14. TGF-beta transcriptionally activates the gene encoding the high-affinity adenosine transporter CNT2 in rat liver parenchymal cells. Vald??s, R., Fern??ndez-Veledo, S., Aymerich, I., Casado, F.J., Pastor-Anglada, M. Cell. Mol. Life Sci. (2006) [Pubmed]
WikiGenes - Universities