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TGFA  -  transforming growth factor, alpha

Macaca mulatta

 
 
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Disease relevance of TGFA

 

High impact information on TGFA

 

Biological context of TGFA

  • The present study was undertaken to examine the hypothesis that hypothalamic expression of the TGF alpha gene and its receptor changes in relation to the stage of sexual development in nonhuman primates, and to determine whether these changes are accompanied by corresponding alterations in LHRH gene expression [4].
 

Anatomical context of TGFA

 

Associations of TGFA with chemical compounds

  • These findings indicate that TGFalpha is probably not involved in mediating the inhibitory action of estradiol on GnRH neurons [3].
  • The effect of transforming growth factor-alpha was studied in histamine-stimulated gastric acid secretion in monkeys and in pylorus-ligated rats [5].
 

Other interactions of TGFA

  • These results demonstrate that increases in TGF alpha and EGFR gene expression, specific to the neuroendocrine brain, occur during developmental phases in which gonadotropin output is also elevated--most noticeably at the time of puberty.(ABSTRACT TRUNCATED AT 400 WORDS)[4]

References

  1. Central administration of transforming growth factor-alpha and neuregulin-1 suppress active behaviors and cause weight loss in hamsters. Snodgrass-Belt, P., Gilbert, J.L., Davis, F.C. Brain Res. (2005) [Pubmed]
  2. Increased gastroduodenal concentrations of transforming growth factor alpha in adaptation to aspirin in monkeys and rats. Romano, M., Lesch, C.A., Meise, K.S., Veljaca, M., Sanchez, B., Kraus, E.R., Boland, C.R., Guglietta, A., Coffey, R.J. Gastroenterology (1996) [Pubmed]
  3. Effect of estrogen on hypothalamic transforming growth factor alpha and gonadotropin-releasing hormone gene expression in the female rhesus monkey. El Majdoubi, M., Sahu, A., Plant, T.M. Neuroendocrinology (1998) [Pubmed]
  4. Developmental expression of the genes encoding transforming growth factor alpha and its receptor in the hypothalamus of female rhesus macaques. Ma, Y.J., Costa, M.E., Ojeda, S.R. Neuroendocrinology (1994) [Pubmed]
  5. Effect of transforming growth factor-alpha on gastric acid secretion in rats and monkeys. Guglietta, A., Lesch, C.A., Romano, M., McClure, R.W., Coffey, R.J. Dig. Dis. Sci. (1994) [Pubmed]
 
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