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Gene Review

TGFA  -  transforming growth factor, alpha

Canis lupus familiaris

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Disease relevance of TGFA


High impact information on TGFA


Biological context of TGFA


Anatomical context of TGFA


Associations of TGFA with chemical compounds

  • The inhibitory action of EGF-URO for agonist (NE, PGF2 alpha or KCl)-mediated contraction was diminished with repeated exposure of the tissue to EGF-URO, whereas the inhibitory action of TGF-alpha persisted with repetitive tissue exposure.(ABSTRACT TRUNCATED AT 250 WORDS)[5]
  • In the mid stage of diestrus, clear staining for TGF-alpha was again found in the glands of the luminal region, and staining for EGF-R was observed in all glands [6].

Other interactions of TGFA


Analytical, diagnostic and therapeutic context of TGFA


  1. Separation of parathyroid hormone-like activity from transforming growth factor-alpha and -beta in the canine adenocarcinoma (CAC-8) model of humoral hypercalcemia of malignancy. Merryman, J.I., Rosol, T.J., Brooks, C.L., Capen, C.C. Endocrinology (1989) [Pubmed]
  2. Expression of transforming growth factor alpha in plutonium-239-induced lung neoplasms in dogs: investigations of autocrine mechanisms of growth. Gillett, N.A., Stegelmeier, B.L., Chang, I.Y., Kelly, G. Radiat. Res. (1991) [Pubmed]
  3. Mitogenic response of canine fundic epithelial cells in short-term culture to transforming growth factor alpha and insulinlike growth factor I. Chen, M.C., Lee, A.T., Soll, A.H. J. Clin. Invest. (1991) [Pubmed]
  4. Transforming growth factor alpha receptor binding sites in the canine gastrointestinal tract. Sottili, M., Sternini, C., Brecha, N.C., Lezoche, E., Walsh, J.H. Gastroenterology (1992) [Pubmed]
  5. Distinct vascular actions of epidermal growth factor-urogastrone and transforming growth factor-alpha. Gan, B.S., Hollenberg, M.D., MacCannell, K.L., Lederis, K., Winkler, M.E., Derynck, R. J. Pharmacol. Exp. Ther. (1987) [Pubmed]
  6. Detection of transforming growth factor-alpha and epidermal growth factor receptor mRNA and immunohistochemical localization of the corresponding proteins in the canine uterus during the estrous cycle. Tamada, H., Tominaga, M., Kida, K., Kawate, N., Inaba, T., Matsuyama, S., Sawada, T. Histol. Histopathol. (2005) [Pubmed]
  7. Screening for candidate hepatic growth factors by selective portal infusion after canine Eck's fistula. Francavilla, A., Starzl, T.E., Porter, K., Foglieni, C.S., Michalopoulos, G.K., Carrieri, G., Trejo, J., Azzarone, A., Barone, M., Zeng, Q.H. Hepatology (1991) [Pubmed]
  8. Cyst fluid from human autosomal dominant polycystic kidneys promotes cyst formation and expansion by renal epithelial cells in vitro. Ye, M., Grant, M., Sharma, M., Elzinga, L., Swan, S., Torres, V.E., Grantham, J.J. J. Am. Soc. Nephrol. (1992) [Pubmed]
  9. Comparative studies of the mitogenic effects of epidermal growth factor and transforming growth factor-alpha and the expression of various growth factors in neoplastic and non-neoplastic prostatic cell lines. Jones, H.E., Eaton, C.L., Barrow, D., Dutkowski, C.M., Gee, J.M., Griffiths, K. Prostate (1997) [Pubmed]
  10. Effect on the canine Eck fistula liver of intraportal TGF-beta alone or with hepatic growth factors. Francavilla, A., Azzarone, A., Carrieri, G., Scotti-Foglieni, C., Zeng, Q.H., Cillo, U., Porter, K., Starzl, T.E. Hepatology (1992) [Pubmed]
  11. Renal cell cultures for the study of growth factor interactions underlying kidney organogenesis. Mattii, L., Bianchi, F., Da Prato, I., Dolfi, A., Bernardini, N. In Vitro Cell. Dev. Biol. Anim. (2001) [Pubmed]
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