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Chemical Compound Review

AGN-PC-00H0XB     2,5- bis(hydroxymethyl)oxolane- 3,4-diol

Synonyms: SureCN4439225, NSC-129241, AC1L1BLU, NSC129241, AR-1D4049, ...
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Psychiatry related information on NSC129241


High impact information on NSC129241


Chemical compound and disease context of NSC129241


Biological context of NSC129241


Anatomical context of NSC129241


Associations of NSC129241 with other chemical compounds

  • Administration of the fructose analog 2,5-anhydro-D-mannitol (2,5-AM) stimulates eating in rats fed a low-fat diet but not in those fed a high-fat diet that enhances fatty acid oxidation [15].
  • Combined administration of methyl palmoxirate (5 mg/kg po), an inhibitor of fatty acid oxidation, and 2,5-anhydro-D-mannitol (150 mg/kg ip), which decreases liver ATP content, increased feeding in rats more than expected on the basis of eating responses after treatment with either inhibitor given alone [16].

Gene context of NSC129241


  1. 2,5-Anhydro-D-mannitol induces Fos-like immunoreactivity in hindbrain and forebrain: relationship to eating behavior. Horn, C.C., Friedman, M.I. Brain Res. (1998) [Pubmed]
  2. A comparison of the effects of food deprivation and 2,5-anhydro-D-mannitol on metabolism and ingestion. Park, C.R., Benthem, L., Seeley, R.J., Friedman, M.I., Wilkinson, C.W., Woods, S.C. Am. J. Physiol. (1996) [Pubmed]
  3. Regulation of carbohydrate metabolism by 2,5-anhydro-D-mannitol. Riquelme, P.T., Wernette-Hammond, M.E., Kneer, N.M., Lardy, H.A. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  4. The sugar phosphate specificity of rat hepatic 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. Pilkis, S.J., Pilkis, J., el-Maghrabi, M.R., Claus, T.H. J. Biol. Chem. (1985) [Pubmed]
  5. Mechanism of action of 2,5-anhydro-D-mannitol in hepatocytes. Effects of phosphorylated metabolites on enzymes of carbohydrate metabolism. Riquelme, P.T., Wernette-Hammond, M.E., Kneer, N.M., Lardy, H.A. J. Biol. Chem. (1984) [Pubmed]
  6. Inhibition of gluconeogenesis and glycogenolysis by 2,5-anhydro-D-mannitol. Hanson, R.L., Ho, R.S., Wiseberg, J.J., Simpson, R., Younathan, E.S., Blair, J.B. J. Biol. Chem. (1984) [Pubmed]
  7. Temporal relationships between eating behavior and liver adenine nucleotides in rats treated with 2,5-AM. Koch, J.E., Ji, H., Osbakken, M.D., Friedman, M.I. Am. J. Physiol. (1998) [Pubmed]
  8. Regulation of food intake by metabolic fuels in white-crowned sparrows. Boswell, T., Richardson, R.D., Seeley, R.J., Ramenofsky, M., Wingfield, J.C., Friedman, M.I., Woods, S.C. Am. J. Physiol. (1995) [Pubmed]
  9. Metabolic inhibition increases feeding and brain Fos-like immunoreactivity as a function of diet. Horn, C.C., Friedman, M.I. Am. J. Physiol. (1998) [Pubmed]
  10. Increased feeding after treatment with fructose, but not glucose, antimetabolites in rats with dopamine-depleting brain lesions. Lu, Y., Rowland, N.E. Brain Res. (1993) [Pubmed]
  11. Interactions of dietary fat and 2,5-anhydro-D-mannitol on energy metabolism in isolated rat hepatocytes. Ji, H., Graczyk-Milbrandt, G., Osbakken, M.D., Friedman, M.I. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2002) [Pubmed]
  12. Effect of 2,5-anhydro-D-mannitol on membrane potential in rat hepatocyte couplets and hepatocyte monolayer cultures. Cermak, R., Scharrer, E. Biochim. Biophys. Acta (1999) [Pubmed]
  13. Ornithine decarboxylase activity in rat intestinal mucosa and liver is stimulated by central administration of 2-deoxy-D-glucose but not of 2,5-anhydro-D-mannitol. Morita, H., Fujimoto, K., Sakata, T., Kurokawa, M., Yoshimatsu, H., Noda, T., Iwakiri, R., Sakai, T. Brain Res. (1996) [Pubmed]
  14. Induction of Fos-like immunoreactivity (Fos-li) and stimulation of feeding by 2,5-anhydro-D-mannitol (2,5-AM) require the vagus nerve. Ritter, S., Dinh, T.T., Friedman, M.I. Brain Res. (1994) [Pubmed]
  15. High-fat diet prevents eating response and attenuates liver ATP decline in rats given 2,5-anhydro-D-mannitol. Friedman, M.I., Koch, J.E., Graczyk-Milbrandt, G., Ulrich, P.M., Osbakken, M.D. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2002) [Pubmed]
  16. Neural substrate for an integrated metabolic control of feeding behavior. Horn, C.C., Addis, A., Friedman, M.I. Am. J. Physiol. (1999) [Pubmed]
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