Gene Review:
SPRY1 - sprouty homolog 1, antagonist of FGF...
Homo sapiens
Synonyms:
Protein sprouty homolog 1, Spry-1, hSPRY1
- A specific region of 37 amino acid residues in the SPRY (B30.2) domain of African green monkey TRIM5alpha determines species-specific restriction of simian immunodeficiency virus SIVmac infection. Nakayama, E.E., Miyoshi, H., Nagai, Y., Shioda, T. J. Virol. (2005)
- TRIM5alpha selectively binds a restriction-sensitive retroviral capsid. Sebastian, S., Luban, J. Retrovirology (2005)
- Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway. Hanafusa, H., Torii, S., Yasunaga, T., Nishida, E. Nat. Cell Biol. (2002)
- Structural and functional insights into the B30.2/SPRY domain. Woo, J.S., Imm, J.H., Min, C.K., Kim, K.J., Cha, S.S., Oh, B.H. EMBO J. (2006)
- Positive selection of primate TRIM5alpha identifies a critical species-specific retroviral restriction domain. Sawyer, S.L., Wu, L.I., Emerman, M., Malik, H.S. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Identification and expression analysis of a novel splice variant of human Sprouty1 gene. Wang, L., Ji, C., Wu, H., Xu, J., Wu, Q., Dai, J., Yin, G., Ye, X., Gu, S., Xie, Y., Mao, Y. Int. J. Mol. Med. (2003)
- Concomitant down-regulation of SPRY1 and SPRY2 in prostate carcinoma. Fritzsche, S., Kenzelmann, M., Hoffmann, M.J., Müller, M., Engers, R., Gröne, H.J., Schulz, W.A. Endocr. Relat. Cancer (2006)
- Regulation of Sprouty2 stability by mammalian Seven-in-Absentia homolog 2. Nadeau, R.J., Toher, J.L., Yang, X., Kovalenko, D., Friesel, R. J. Cell. Biochem. (2007)
- Assignment of SPROUTY 1 (SPRY1) gene to tammar wallaby chromosome 6 by fluorescence in situ hybridisation. Charchar, F.J., Svartman, M., Graves, J.A. Cytogenet. Cell Genet. (2000)
- Sprouty proteins are targeted to membrane ruffles upon growth factor receptor tyrosine kinase activation. Identification of a novel translocation domain. Lim, J., Wong, E.S., Ong, S.H., Yusoff, P., Low, B.C., Guy, G.R. J. Biol. Chem. (2000)
- A Src Homology 3-binding Sequence on the C Terminus of Sprouty2 Is Necessary for Inhibition of the Ras/ERK Pathway Downstream of Fibroblast Growth Factor Receptor Stimulation. Lao, D.H., Chandramouli, S., Yusoff, P., Fong, C.W., Saw, T.Y., Tai, L.P., Yu, C.Y., Leong, H.F., Guy, G.R. J. Biol. Chem. (2006)
- The cysteine-rich sprouty translocation domain targets mitogen-activated protein kinase inhibitory proteins to phosphatidylinositol 4,5-bisphosphate in plasma membranes. Lim, J., Yusoff, P., Wong, E.S., Chandramouli, S., Lao, D.H., Fong, C.W., Guy, G.R. Mol. Cell. Biol. (2002)
- Tyrosine phosphorylation of Sprouty2 enhances its interaction with c-Cbl and is crucial for its function. Fong, C.W., Leong, H.F., Wong, E.S., Lim, J., Yusoff, P., Guy, G.R. J. Biol. Chem. (2003)
- Dual Effects of Sprouty1 on TCR Signaling Depending on the Differentiation State of the T Cell. Choi, H., Cho, S.Y., Schwartz, R.H., Choi, K. J. Immunol. (2006)
- FGF signaling inhibitor, SPRY4, is evolutionarily conserved target of WNT signaling pathway in progenitor cells. Katoh, Y., Katoh, M. Int. J. Mol. Med. (2006)
- Human placental Hofbauer cells express sprouty proteins: a possible modulating mechanism of villous branching. Anteby, E.Y., Natanson-Yaron, S., Greenfield, C., Goldman-Wohl, D., Haimov-Kochman, R., Holzer, H., Yagel, S. Placenta (2005)
- Dynamics of the SPRY domain-containing SOCS box protein 2: Flexibility of key functional loops. Yao, S., Liu, M.S., Masters, S.L., Zhang, J.G., Babon, J.J., Nicola, N.A., Nicholson, S.E., Norton, R.S. Protein Sci. (2006)