Gene Review:
HMGB1 - high mobility group box 1
Homo sapiens
Synonyms:
DKFZp686A04236, HMG-1, HMG1, HMG3, High mobility group protein 1, ...
- HMG-1 as a late mediator of endotoxin lethality in mice. Wang, H., Bloom, O., Zhang, M., Vishnubhakat, J.M., Ombrellino, M., Che, J., Frazier, A., Yang, H., Ivanova, S., Borovikova, L., Manogue, K.R., Faist, E., Abraham, E., Andersson, J., Andersson, U., Molina, P.E., Abumrad, N.N., Sama, A., Tracey, K.J. Science. (1999)
- Therapeutic potential of HMGB1-targeting agents in sepsis. Wang, H., Zhu, S., Zhou, R., Li, W., Sama, A.E. Expert. Rev. Mol. Med. (2008)
- Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Scaffidi, P., Misteli, T., Bianchi, M.E. Nature (2002)
- Overexpression of high mobility group box 1 in gastrointestinal stromal tumors with KIT mutation. Choi, Y.R., Kim, H., Kang, H.J., Kim, N.G., Kim, J.J., Park, K.S., Paik, Y.K., Kim, H.O., Kim, H. Cancer Res. (2003)
- Cutting edge: high-mobility group box 1 preconditioning protects against liver ischemia-reperfusion injury. Izuishi, K., Tsung, A., Jeyabalan, G., Critchlow, N.D., Li, J., Tracey, K.J., Demarco, R.A., Lotze, M.T., Fink, M.P., Geller, D.A., Billiar, T.R. J. Immunol. (2006)
- Colon cancer cell-derived high mobility group 1/amphoterin induces growth inhibition and apoptosis in macrophages. Kuniyasu, H., Yano, S., Sasaki, T., Sasahira, T., Sone, S., Ohmori, H. Am. J. Pathol. (2005)
- Angiogenetic signaling through hypoxia: HMGB1: an angiogenetic switch molecule. Schlueter, C., Weber, H., Meyer, B., Rogalla, P., Röser, K., Hauke, S., Bullerdiek, J. Am. J. Pathol. (2005)
- Reversing established sepsis with antagonists of endogenous high-mobility group box 1. Yang, H., Ochani, M., Li, J., Qiang, X., Tanovic, M., Harris, H.E., Susarla, S.M., Ulloa, L., Wang, H., DiRaimo, R., Czura, C.J., Wang, H., Roth, J., Warren, H.S., Fink, M.P., Fenton, M.J., Andersson, U., Tracey, K.J. Proc. Natl. Acad. Sci. U. S. A. (2004)
- Role of HMGB1 in cardiovascular diseases. Li, W., Sama, A.E., Wang, H. Curr. Opin. Pharmacol (2006)
- Circulating high-mobility group box 1 (HMGB1) concentrations are elevated in both uncomplicated pneumonia and pneumonia with severe sepsis. Angus, D.C., Yang, L., Kong, L., Kellum, J.A., Delude, R.L., Tracey, K.J., Weissfeld, L. Crit. Care Med. (2007)
- Masquerader: high mobility group box-1 and cancer. Ellerman, J.E., Brown, C.K., de Vera, M., Zeh, H.J., Billiar, T., Rubartelli, A., Lotze, M.T. Clin. Cancer Res. (2007)
- High mobility group box 1 protein binding to lipopolysaccharide facilitates transfer of lipopolysaccharide to CD14 and enhances lipopolysaccharide-mediated TNF-alpha production in human monocytes. Youn, J.H., Oh, Y.J., Kim, E.S., Choi, J.E., Shin, J.S. J. Immunol. (2008)
- alpha-Synuclein filaments bind the transcriptional regulator HMGB-1. Lindersson, E.K., Højrup, P., Gai, W.P., Locker, D., Martin, D., Jensen, P.H. Neuroreport (2004)
- Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Grant, S.F., Thorleifsson, G., Reynisdottir, I., Benediktsson, R., Manolescu, A., Sainz, J., Helgason, A., Stefansson, H., Emilsson, V., Helgadottir, A., Styrkarsdottir, U., Magnusson, K.P., Walters, G.B., Palsdottir, E., Jonsdottir, T., Gudmundsdottir, T., Gylfason, A., Saemundsdottir, J., Wilensky, R.L., Reilly, M.P., Rader, D.J., Bagger, Y., Christiansen, C., Gudnason, V., Sigurdsson, G., Thorsteinsdottir, U., Gulcher, J.R., Kong, A., Stefansson, K. Nat. Genet. (2006)
- Recurrent rearrangements in the high mobility group protein gene, HMGI-C, in benign mesenchymal tumours. Schoenmakers, E.F., Wanschura, S., Mols, R., Bullerdiek, J., Van den Berghe, H., Van de Ven, W.J. Nat. Genet. (1995)
- Molecular basis of human 46X,Y sex reversal revealed from the three-dimensional solution structure of the human SRY-DNA complex. Werner, M.H., Huth, J.R., Gronenborn, A.M., Clore, G.M. Cell (1995)
- The high mobility group protein HMG I(Y) is required for NF-kappa B-dependent virus induction of the human IFN-beta gene. Thanos, D., Maniatis, T. Cell (1992)
- Microinjection of the nonhistone chromosomal protein HMG1 into bovine fibroblasts and HeLa cells. Rechsteiner, M., Kuehl, L. Cell (1979)
- Effects of spectator ligands on the specific recognition of intrastrand platinum-DNA cross-links by high mobility group box and TATA-binding proteins. Wei, M., Cohen, S.M., Silverman, A.P., Lippard, S.J. J. Biol. Chem. (2001)
- The human HMGB1 promoter is modulated by a silencer and an enhancer-containing intron. Lum, H.K., Lee, K.L. Biochim. Biophys. Acta (2001)
- Down-regulation of the aberrant expression of the inflammation mediator high mobility group box chromosomal protein 1 in muscle tissue of patients with polymyositis and dermatomyositis treated with corticosteroids. Ulfgren, A.K., Grundtman, C., Borg, K., Alexanderson, H., Andersson, U., Harris, H.E., Lundberg, I.E. Arthritis Rheum. (2004)
- Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis. Wang, H., Liao, H., Ochani, M., Justiniani, M., Lin, X., Yang, L., Al-Abed, Y., Wang, H., Metz, C., Miller, E.J., Tracey, K.J., Ulloa, L. Nat. Med. (2004)
- Association of chromatin proteins high mobility group box (HMGB) 1 and HMGB2 with mitotic chromosomes. Pallier, C., Scaffidi, P., Chopineau-Proust, S., Agresti, A., Nordmann, P., Bianchi, M.E., Marechal, V. Mol. Biol. Cell (2003)
- Nucleocytoplasmic Shuttling of HMGB1 Is Regulated by Phosphorylation That Redirects It toward Secretion. Youn, J.H., Shin, J.S. J. Immunol. (2006)
- HMGB1 and HMGB2 cell-specifically down-regulate the p53- and p73-dependent sequence-specific transactivation from the human Bax gene promoter. Stros, M., Ozaki, T., Bacikova, A., Kageyama, H., Nakagawara, A. J. Biol. Chem. (2002)
- High Mobility Group B1 Protein Suppresses the Human Plasmacytoid Dendritic Cell Response to TLR9 Agonists. Popovic, P.J., Demarco, R., Lotze, M.T., Winikoff, S.E., Bartlett, D.L., Krieg, A.M., Guo, Z.S., Brown, C.K., Tracey, K.J., Zeh, H.J. J. Immunol. (2006)
- Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion. Bonaldi, T., Talamo, F., Scaffidi, P., Ferrera, D., Porto, A., Bachi, A., Rubartelli, A., Agresti, A., Bianchi, M.E. EMBO J. (2003)
- Inflammation-promoting activity of HMGB1 on human microvascular endothelial cells. Fiuza, C., Bustin, M., Talwar, S., Tropea, M., Gerstenberger, E., Shelhamer, J.H., Suffredini, A.F. Blood (2003)
- The role of IFN-alpha and nitric oxide in the release of HMGB1 by RAW 264.7 cells stimulated with polyinosinic-polycytidylic acid or lipopolysaccharide. Jiang, W., Pisetsky, D.S. J. Immunol. (2006)
- HMGB1 activates replication of latent HIV-1 in a monocytic cell-line, but inhibits HIV-1 replication in primary macrophages. Nowak, P., Barqasho, B., Treutiger, C.J., Harris, H.E., Tracey, K.J., Andersson, J., Sönnerborg, A. Cytokine (2006)
- High-mobility group box 1 activates integrin-dependent homing of endothelial progenitor cells. Chavakis, E., Hain, A., Vinci, M., Carmona, G., Bianchi, M.E., Vajkoczy, P., Zeiher, A.M., Chavakis, T., Dimmeler, S. Circ. Res. (2007)
- HMGB1 develops enhanced proinflammatory activity by binding to cytokines. Sha, Y., Zmijewski, J., Xu, Z., Abraham, E. J. Immunol. (2008)
- Release of HMGB1 in response to proapoptotic glioma killing strategies: efficacy and neurotoxicity. Candolfi, M., Yagiz, K., Foulad, D., Alzadeh, G.E., Tesarfreund, M., Muhammad, A.K., Puntel, M., Kroeger, K.M., Liu, C., Lee, S., Curtin, J.F., King, G.D., Lerner, J., Sato, K., Mineharu, Y., Xiong, W., Lowenstein, P.R., Castro, M.G. Clin. Cancer Res. (2009)
- Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity. Antoine, D.J., Jenkins, R.E., Dear, J.W., Williams, D.P., McGill, M.R., Sharpe, M.R., Craig, D.G., Simpson, K.J., Jaeschke, H., Park, B.K. J. Hepatol. (2012)
- The role of the C-terminal extension (CTE) of the estrogen receptor alpha and beta DNA binding domain in DNA binding and interaction with HMGB. Melvin, V.S., Harrell, C., Adelman, J.S., Kraus, W.L., Churchill, M., Edwards, D.P. J. Biol. Chem. (2004)
- High mobility group protein 1 interacts specifically with the core domain of human TATA box-binding protein and interferes with transcription factor IIB within the pre-initiation complex. Sutrias-Grau, M., Bianchi, M.E., Bernués, J. J. Biol. Chem. (1999)
- High-affinity binding of tumor-suppressor protein p53 and HMGB1 to hemicatenated DNA loops. Stros, M., Muselíková-Polanská, E., Pospísilová, S., Strauss, F. Biochemistry (2004)
- The RAG1 homeodomain recruits HMG1 and HMG2 to facilitate recombination signal sequence binding and to enhance the intrinsic DNA-bending activity of RAG1-RAG2. Aidinis, V., Bonaldi, T., Beltrame, M., Santagata, S., Bianchi, M.E., Spanopoulou, E. Mol. Cell. Biol. (1999)
- Role of high mobility group protein-1 (HMG1) in amyloid-beta homeostasis. Takata, K., Kitamura, Y., Kakimura, J., Shibagaki, K., Tsuchiya, D., Taniguchi, T., Smith, M.A., Perry, G., Shimohama, S. Biochem. Biophys. Res. Commun. (2003)
- Growth suppression and radiosensitivity increase by HMGB1 in breast cancer. Jiao, Y., Wang, H.C., Fan, S.J. Acta. Pharmacol. Sin. (2007)
- Purification and postsynthetic modifications of Friend erythroleukemic cell high mobility group protein HMG-I. Elton, T.S., Reeves, R. Anal. Biochem. (1986)
- Identity of the in vivo phosphorylation site in high mobility group 14 protein in HeLa cells with the site phosphorylated by casein kinase II in vitro. Walton, G.M., Gill, G.N. J. Biol. Chem. (1983)
- HMGB1 signals through toll-like receptor (TLR) 4 and TLR2. Yu, M., Wang, H., Ding, A., Golenbock, D.T., Latz, E., Czura, C.J., Fenton, M.J., Tracey, K.J., Yang, H. Shock (2006)
- High mobility group B proteins facilitate strong estrogen receptor binding to classical and half-site estrogen response elements and relax binding selectivity. Das, D., Peterson, R.C., Scovell, W.M. Mol. Endocrinol. (2004)
- The high mobility group protein HMG1 can reversibly inhibit class II gene transcription by interaction with the TATA-binding protein. Ge, H., Roeder, R.G. J. Biol. Chem. (1994)
- High mobility group box chromosomal protein 1 plays a role in the pathogenesis of rheumatoid arthritis as a novel cytokine. Taniguchi, N., Kawahara, K., Yone, K., Hashiguchi, T., Yamakuchi, M., Goto, M., Inoue, K., Yamada, S., Ijiri, K., Matsunaga, S., Nakajima, T., Komiya, S., Maruyama, I. Arthritis Rheum. (2003)
- Functions of MutLalpha, replication protein A (RPA), and HMGB1 in 5'-directed mismatch repair. Genschel, J., Modrich, P. J. Biol. Chem. (2009)
- High mobility group protein-1 (HMG-1) is a unique activator of p53. Jayaraman, L., Moorthy, N.C., Murthy, K.G., Manley, J.L., Bustin, M., Prives, C. Genes Dev. (1998)
- High-mobility group chromatin proteins 1 and 2 functionally interact with steroid hormone receptors to enhance their DNA binding in vitro and transcriptional activity in mammalian cells. Boonyaratanakornkit, V., Melvin, V., Prendergast, P., Altmann, M., Ronfani, L., Bianchi, M.E., Taraseviciene, L., Nordeen, S.K., Allegretto, E.A., Edwards, D.P. Mol. Cell. Biol. (1998)
- Protein kinase CK2 differentially phosphorylates maize chromosomal high mobility group B (HMGB) proteins modulating their stability and DNA interactions. Stemmer, C., Schwander, A., Bauw, G., Fojan, P., Grasser, K.D. J. Biol. Chem. (2002)
- Nuclear heat shock protein 72 as a negative regulator of oxidative stress (hydrogen peroxide)-induced HMGB1 cytoplasmic translocation and release. Tang, D., Kang, R., Xiao, W., Jiang, L., Liu, M., Shi, Y., Wang, K., Wang, H., Xiao, X. J. Immunol. (2007)
- A major ingredient of green tea rescues mice from lethal sepsis partly by inhibiting HMGB1. Li, W., Ashok, M., Li, J., Yang, H., Sama, A.E., Wang, H. PLoS. One. (2007)
- A cardiovascular drug rescues mice from lethal sepsis by selectively attenuating a late-acting proinflammatory mediator, high mobility group box 1. Li, W., Li, J., Ashok, M., Wu, R., Chen, D., Yang, L., Yang, H., Tracey, K.J., Wang, P., Sama, A.E., Wang, H. J. Immunol. (2007)
- Contributions of high mobility group box protein in experimental and clinical acute lung injury. Ueno, H., Matsuda, T., Hashimoto, S., Amaya, F., Kitamura, Y., Tanaka, M., Kobayashi, A., Maruyama, I., Yamada, S., Hasegawa, N., Soejima, J., Koh, H., Ishizaka, A. Am. J. Respir. Crit. Care Med. (2004)
- Factors masking HMGB1 in human serum and plasma. Urbonaviciute, V., F??rnrohr, B.G., Weber, C., Haslbeck, M., Wilhelm, S., Herrmann, M., Voll, R.E. J. Leukoc. Biol. (2007)