Disease relevance of BYSL

• Identification of CCND3 and BYSL as candidate targets for the 6p21 amplification in diffuse large B-cell lymphoma [1].
• We hypothesized that trophinin's function in embryo implantation is unique to humans and investigated the expression of trophinin, tastin, and bystin in ectopic pregnancy, a condition unique to humans [2].
• Bystin in perineural invasion of prostate cancer [3].

High impact information on BYSL

• The present study identifies a cytoplasmic protein, named bystin, that directly binds trophinin and tastin [4].
• Bystin consists of 306 amino acid residues and is predicted to contain tyrosine, serine, and threonine residues in contexts conforming to motifs for phosphorylation by protein kinases [4].
• Trophinin, tastin, and bystin have been identified as molecules potentially involved in human embryo implantation [2].
• Overexpression of CCND3 through genomic amplification is likely to lead to aberrant cell cycle control, although the precise biological role of BYSL with respect to tumorigenesis remains to be determined [1].
• Expression of trophinin and bystin identifies distinct cell types in the germinal zones of adult rat brain [5].

Biological context of BYSL

• Trophinin, tastin, and bystin comprise a complex mediating a unique homophilic cell adhesion between trophoblast and endometrial epithelial cells at their respective apical cell surfaces [6].
• Assignment1 of the bystin gene BYSL to human chromosome band 6p21.1 by in situ hybridization [7].

Anatomical context of BYSL

• In placenta from the 6th week of pregnancy, trophinin and bystin were found in the cytoplasm of the syncytiotrophoblast in the chorionic villi, and in endometrial decidual cells at the utero placental interface [6].
• The unique expression pattern and cell adhesion activity exhibited by trophinin, tastin, and bystin suggest strongly the involvement of these molecules in the initial attachment of blastocyst to uterus [8].
• Recent molecular approaches to elucidate the mechanism of embryo implantation: trophinin, bystin, and tastin as molecules involved in the initial attachment of blastocysts to the uterus in humans [9].

Associations of BYSL with chemical compounds

• The present study shows that bystin is expressed in luminal and glandular epithelia in the mouse uterus at peri-implantation stages [10].

Analytical, diagnostic and therapeutic context of BYSL

• Bystin is present in the supernatant of the PNI co-culture [3].
• METHODS: Profiling of genes differentially expressed in the perineural invasion (PNI) in vitro model by gene microarray analysis showed overexpression of bystin in prostate cancer cells co-cultured with nerves [3].

References