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Gene Review

UPK3A  -  uroplakin 3A

Homo sapiens

Synonyms: UP3A, UP3a, UPIII, UPIIIA, UPK3, ...
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Disease relevance of UPK3A


High impact information on UPK3A

  • Normal urothelium expressed mRNA for all four uroplakins, although UPIII could be detected only by ribonuclease protection assay [4].
  • We have shown recently that a 47 kDa glycoprotein, uroplakin III (UPIII), in conjunction with uroplakins I (27 kDa) and II (15 kDa), forms the asymmetric unit membrane (AUM)--a highly specialized biomembrane characteristic of the apical surface of bladder epithelium [5].
  • Impaired p63 expression associates with poor prognosis and uroplakin III expression in invasive urothelial carcinoma of the bladder [6].
  • The combination of UPIb/UPIII was the most specific (79%) but had modest sensitivity (31%) [7].
  • Here it is shown shown that synaptobrevin, SNAP23 and syntaxin are perfectly colocalized with uroplakin III at the apical plasma membrane as well as with membranes of discoid vesicles [8].

Biological context of UPK3A


Anatomical context of UPK3A


Associations of UPK3A with chemical compounds

  • At 2, 4, and 12 weeks after grafting, cystometry was performed with the rats under pentobarbital anesthesia, and the bladders were subsequently harvested and immunostained with anti-PGP9.5, uroplakin III, and alpha-smooth muscle actin antibodies (n = 5 each time) [13].

Other interactions of UPK3A

  • As in normal and neoplastic bladder urothelium, urothelial markers, including uroplakin III, CK13, and CK20, were detected in the epithelial nests of Brenner tumors [14].

Analytical, diagnostic and therapeutic context of UPK3A


  1. Expression of uroplakin Ib and uroplakin III genes in tissues and peripheral blood of patients with transitional cell carcinoma. Yuasa, T., Yoshiki, T., Tanaka, T., Kim, C.J., Isono, T., Okada, Y. Jpn. J. Cancer Res. (1998) [Pubmed]
  2. Uroplakin III is a highly specific and moderately sensitive immunohistochemical marker for primary and metastatic urothelial carcinomas. Kaufmann, O., Volmerig, J., Dietel, M. Am. J. Clin. Pathol. (2000) [Pubmed]
  3. Immunohistochemistry as a tool in the differential diagnosis of ovarian tumors: an update. Baker, P.M., Oliva, E. Int. J. Gynecol. Pathol. (2005) [Pubmed]
  4. Uroplakin gene expression by normal and neoplastic human urothelium. Lobban, E.D., Smith, B.A., Hall, G.D., Harnden, P., Roberts, P., Selby, P.J., Trejdosiewicz, L.K., Southgate, J. Am. J. Pathol. (1998) [Pubmed]
  5. Molecular cloning of a 47 kDa tissue-specific and differentiation-dependent urothelial cell surface glycoprotein. Wu, X.R., Sun, T.T. J. Cell. Sci. (1993) [Pubmed]
  6. Impaired p63 expression associates with poor prognosis and uroplakin III expression in invasive urothelial carcinoma of the bladder. Koga, F., Kawakami, S., Fujii, Y., Saito, K., Ohtsuka, Y., Iwai, A., Ando, N., Takizawa, T., Kageyama, Y., Kihara, K. Clin. Cancer Res. (2003) [Pubmed]
  7. Detection of circulating cancer cells expressing uroplakins and epidermal growth factor receptor in bladder cancer patients. Osman, I., Kang, M., Lee, A., Deng, F.M., Polsky, D., Mikhail, M., Chang, C., David, D.A., Mitra, N., Wu, X.R., Sun, T.T., Bajorin, D.F. Int. J. Cancer (2004) [Pubmed]
  8. The maintenance of the permeability barrier of bladder facet cells requires a continuous fusion of discoid vesicles with the apical plasma membrane. Born, M., Pahner, I., Ahnert-Hilger, G., Jöns, T. Eur. J. Cell Biol. (2003) [Pubmed]
  9. Chromosomal localization of uroplakin genes of cattle and mice. Ryan, A.M., Womack, J.E., Yu, J., Lin, J.H., Wu, X.R., Sun, T.T., Clarke, V., D'Eustachio, P. Mamm. Genome (1993) [Pubmed]
  10. Primary ureteral reflux: emerging insights from molecular and genetic studies. Mak, R.H., Kuo, H.J. Curr. Opin. Pediatr. (2003) [Pubmed]
  11. Urothelial umbrella cells of human ureter are heterogeneous with respect to their uroplakin composition: different degrees of urothelial maturity in ureter and bladder? Riedel, I., Liang, F.X., Deng, F.M., Tu, L., Kreibich, G., Wu, X.R., Sun, T.T., Hergt, M., Moll, R. Eur. J. Cell Biol. (2005) [Pubmed]
  12. Loss of uroplakin III expression is associated with a poor prognosis in patients with urothelial carcinoma of the upper urinary tract. Ohtsuka, Y., Kawakami, S., Fujii, Y., Koga, F., Saito, K., Ando, N., Takizawa, T., Kageyama, Y., Kihara, K. BJU Int. (2006) [Pubmed]
  13. Bladder acellular matrix grafting regenerates urinary bladder in the spinal cord injury rat. Obara, T., Matsuura, S., Narita, S., Satoh, S., Tsuchiya, N., Habuchi, T. Urology (2006) [Pubmed]
  14. Brenner tumors but not transitional cell carcinomas of the ovary show urothelial differentiation: immunohistochemical staining of urothelial markers, including cytokeratins and uroplakins. Riedel, I., Czernobilsky, B., Lifschitz-Mercer, B., Roth, L.M., Wu, X.R., Sun, T.T., Moll, R. Virchows Arch. (2001) [Pubmed]
  15. Immunohistochemistry in diagnostic surgical pathology of the prostate. Hameed, O., Humphrey, P.A. Seminars in diagnostic pathology. (2005) [Pubmed]
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