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Gene Review

KRT20  -  keratin 20, type I

Homo sapiens

Synonyms: CD20, CK-20, CK20, Cytokeratin-20, K20, ...
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Disease relevance of KRT20


Psychiatry related information on KRT20


High impact information on KRT20

  • The crystal structure reveals the basis of the specificity of the enzyme for H4-K20 because a histidine residue within the substrate, close to the target lysine, is required for completion of the active site [9].
  • These results establish the HCF-1C subunit as an important M phase regulator and suggest that H4-K20 methylation status contributes to chromosome behavior during mitosis and proper cytokinesis [10].
  • Here, we show that HCF-1C subunit depletion causes extensive mitotic defects, including a switch from monomethyl to dimethyl lysine 20 of histone H4 (H4-K20) and defective chromosome alignment and segregation [10].
  • Indeed, upregulation of PR-Set7 expression upon loss of HCF-1 leads to improper mitotic H4-K20 methylation and cytokinesis defects [10].
  • Analysis of reaction products by reverse phase high performance liquid chromatography and gas phase sequencing demonstrated the exclusive myristyl acylation of K19 and K20, consistent with the presence in monocytes of a specific lysyl N-epsilon-NH2-myristyl transferase activity [11].

Chemical compound and disease context of KRT20


Biological context of KRT20


Anatomical context of KRT20


Associations of KRT20 with chemical compounds

  • CK7 and CK20 have limited utility in distinguishing HCC from CC or MA, and Factor XIII-A is not useful [24].
  • The expression of laminin-1 chains (beta1 and gamma1), laminin-2 (merosin), integrin receptors to laminin (alpha3beta1 and alpha6beta4) and cytokeratin (CK20) were studied by immunohistochemical methods in gastric biopsies from antrum of 25 patients [25].
  • All the tumors were negative for CK20, estrogen and progesterone receptors, Her2Neu, and p53 [26].
  • Paraffin-embedded tissue from the ovary and jejunum was stained with hematoxylin and eosin, as well as with immunohistochemical stains for cytokeratin 20 and cytokeratin 7 [27].
  • Tumor-suspect nodules previously considered disease free by HE stain on whole-mount section were examined by in situ hybridization (ISH) on tissue microarray (TMA) through detecting mRNAs of CEA and CK20 with non radioactive biotin-tagged oligonucleotide probes [28].

Enzymatic interactions of KRT20

  • CDX2 expression (at 10% and 50% cut-off levels) and the CK20/CK7 pattern of the metastases were correlated to the primary site established [29].

Co-localisations of KRT20


Regulatory relationships of KRT20


Other interactions of KRT20


Analytical, diagnostic and therapeutic context of KRT20

  • In this study, we compared real-time RT-PCR for CEA and CK20 and analysed patients with metastatic disease (n=32) and healthy volunteers (n=17) [36].
  • CK20 mean values were elevated in cancer patients (P<0.001) and defined a subgroup (38%) who showed CK20 levels at least 100-fold above the highest value of the healthy control group [36].
  • We surveyed 435 epithelial neoplasms from various organ systems by immunohistochemistry using CK 7 and CK 20 monoclonal antibodies [3].
  • CEA or CK-20 or GCC-specific polymerase chain reaction (PCR) was carried out on mRNA transcripts extracted from the nodal tissues [37].
  • Detection of CK-20 and CEA mRNA correlated in nine of 12 cases (75.0%) with the risk of tumour recurrence (not significant) and showed a tendency towards shorter disease-free survival by univariate analysis (not significant) [38].


  1. Increased detection of circulating tumor cells in the blood of colorectal carcinoma patients using two reverse transcription-PCR assays and multiple blood samples. Wharton, R.Q., Jonas, S.K., Glover, C., Khan, Z.A., Klokouzas, A., Quinn, H., Henry, M., Allen-Mersh, T.G. Clin. Cancer Res. (1999) [Pubmed]
  2. Villin, cytokeratin 7, and cytokeratin 20 expression in pulmonary adenocarcinoma with ultrastructural evidence of microvilli with rootlets. Tan, J., Sidhu, G., Greco, M.A., Ballard, H., Wieczorek, R. Hum. Pathol. (1998) [Pubmed]
  3. Cytokeratin 7 and cytokeratin 20 expression in epithelial neoplasms: a survey of 435 cases. Chu, P., Wu, E., Weiss, L.M. Mod. Pathol. (2000) [Pubmed]
  4. Immunohistochemical expression of CDX2 in primary ovarian mucinous tumors and metastatic mucinous carcinomas involving the ovary: comparison with CK20 and correlation with coordinate expression of CK7. Vang, R., Gown, A.M., Wu, L.S., Barry, T.S., Wheeler, D.T., Yemelyanova, A., Seidman, J.D., Ronnett, B.M. Mod. Pathol. (2006) [Pubmed]
  5. Primary neuroendocrine carcinoma of the vagina with Merkel cell carcinoma phenotype. Coleman, N.M., Smith-Zagone, M.J., Tanyi, J., Anderson, M.L., Coleman, R.L., Dyson, S.W., Reed, J.A. Am. J. Surg. Pathol. (2006) [Pubmed]
  6. FGFR3 mutations and a normal CK20 staining pattern define low-grade noninvasive urothelial bladder tumours. van Oers, J.M., Wild, P.J., Burger, M., Denzinger, S., Stoehr, R., Rosskopf, E., Hofstaedter, F., Steyerberg, E.W., Klinkhammer-Schalke, M., Zwarthoff, E.C., van der Kwast, T.H., Hartmann, A. Eur. Urol. (2007) [Pubmed]
  7. A surface glycoprotein complex related to the adhesive receptors of the VLA family, shared by epidermal Langerhans cells and basal keratinocytes. Staquet, M.J., Dezutter-Dambuyant, C., Schmitt, D., Amiot, M., Boumsell, L., Thivolet, J. J. Invest. Dermatol. (1989) [Pubmed]
  8. Pancreatic tumors in patients with lung malignancies: a spectrum of clinicopathologic considerations. Schwarz, R.E., Chu, P.G., Grannis, F.W. South. Med. J. (2004) [Pubmed]
  9. Specificity and mechanism of the histone methyltransferase Pr-Set7. Xiao, B., Jing, C., Kelly, G., Walker, P.A., Muskett, F.W., Frenkiel, T.A., Martin, S.R., Sarma, K., Reinberg, D., Gamblin, S.J., Wilson, J.R. Genes Dev. (2005) [Pubmed]
  10. A switch in mitotic histone H4 lysine 20 methylation status is linked to M phase defects upon loss of HCF-1. Julien, E., Herr, W. Mol. Cell (2004) [Pubmed]
  11. Myristyl acylation of the tumor necrosis factor alpha precursor on specific lysine residues. Stevenson, F.T., Bursten, S.L., Locksley, R.M., Lovett, D.H. J. Exp. Med. (1992) [Pubmed]
  12. Cytokeratin 7 and cytokeratin 20 in primary urinary bladder carcinoma and matched lymph node metastasis. Jiang, J., Ulbright, T.M., Younger, C., Sanchez, K., Bostwick, D.G., Koch, M.O., Eble, J.N., Cheng, L. Arch. Pathol. Lab. Med. (2001) [Pubmed]
  13. Cylindroma (dermal analog tumor) of the breast: a comparison with cylindroma of the skin and adenoid cystic carcinoma of the breast. Albores-Saavedra, J., Heard, S.C., McLaren, B., Kamino, H., Witkiewicz, A.K. Am. J. Clin. Pathol. (2005) [Pubmed]
  14. Immunohistochemical differentiation of metastatic breast carcinomas from metastatic adenocarcinomas of other common primary sites. Kaufmann, O., Deidesheimer, T., Muehlenberg, M., Deicke, P., Dietel, M. Histopathology (1996) [Pubmed]
  15. Highly augmented cytopathic effect of a fiber-mutant E1B-defective adenovirus for gene therapy of gliomas. Shinoura, N., Yoshida, Y., Tsunoda, R., Ohashi, M., Zhang, W., Asai, A., Kirino, T., Hamada, H. Cancer Res. (1999) [Pubmed]
  16. Mucinous carcinoid as an unusual manifestation of endodermal differentiation in ovarian yolk sac tumors. Nogales, F.F., Buriticá, C., Regauer, S., González, T. Am. J. Surg. Pathol. (2005) [Pubmed]
  17. Reduced expression of cytokeratin 20 in colorectal carcinomas with high levels of microsatellite instability. McGregor, D.K., Wu, T.T., Rashid, A., Luthra, R., Hamilton, S.R. Am. J. Surg. Pathol. (2004) [Pubmed]
  18. Expression of thyroid transcription factor-1, cytokeratin 7, and cytokeratin 20 in bronchioloalveolar carcinomas: an immunohistochemical evaluation of 67 cases. Lau, S.K., Desrochers, M.J., Luthringer, D.J. Mod. Pathol. (2002) [Pubmed]
  19. Quantitative estimation of CEA and CK20 expression in tumour tissue of colorectal cancer and its liver metastases with reverse transcription and real-time PCR. Cerna, M., Holubec, L., Pesta, M., Kormunda, S., Topolcan, O., Cerny, R. Anticancer Res. (2006) [Pubmed]
  20. Quantitative real-time RT-PCR detection for CEA, CK20 and CK19 mRNA in peripheral blood of colorectal cancer patients. Xu, D., Li, X.F., Zheng, S., Jiang, W.Z. Journal of Zhejiang University. Science. B. (2006) [Pubmed]
  21. Detection of occult tumour cells in lymph nodes of colorectal cancer patients using real-time quantitative RT-PCR for CEA and CK20 mRNAS. Oberg, A.N., Lindmark, G.E., Israelsson, A.C., Hammarström, S.G., Hammarström, M.L. Int. J. Cancer (2004) [Pubmed]
  22. Intraepidermal cytokeratin 7 expression is not restricted to Paget cells but is also seen in Toker cells and Merkel cells. Lundquist, K., Kohler, S., Rouse, R.V. Am. J. Surg. Pathol. (1999) [Pubmed]
  23. Alteration of cytokeratin 7 and cytokeratin 20 expression profile is uniquely associated with tumorigenesis of primary adenocarcinoma of the small intestine. Chen, Z.M., Wang, H.L. Am. J. Surg. Pathol. (2004) [Pubmed]
  24. Immunohistochemical analysis of hepatocellular and adenocarcinoma in the liver: MOC31 compares favorably with other putative markers. Porcell, A.I., De Young, B.R., Proca, D.M., Frankel, W.L. Mod. Pathol. (2000) [Pubmed]
  25. Differential expression of laminin isoform (alpha2), integrins (alpha3beta1 and alpha6beta4) and cytokeratin 20 in H. pylori gastritis. Sales, M.G., Nasciutti, L.E., Lorena, D.E., Muzzi, M., Porto, L.C. Histol. Histopathol. (2001) [Pubmed]
  26. Low-grade intraductal carcinoma of salivary gland: report of 3 cases with marked apocrine differentiation. Weinreb, I., Tabanda-Lichauco, R., Van der Kwast, T., Perez-Ordoñez, B. Am. J. Surg. Pathol. (2006) [Pubmed]
  27. Jejunal adenocarcinoma presenting as a primary ovarian carcinoma. Kilic, G., Abadi, M. Gynecol. Oncol. (2000) [Pubmed]
  28. Regional micrometastasis of low rectal cancer in mesorectum: a study utilizing HE stain on whole-mount section and ISH analyses on tissue microarray. Wang, Z., Zhou, Z.G., Wang, C., Zheng, X.L., Wang, R., Li, F.Y., Guo, J., Jiang, L.L. Cancer Invest. (2006) [Pubmed]
  29. Identifying colorectal metastases in liver biopsies: the novel CDX2 antibody is less specific than the cytokeratin 20+/7- phenotype. Tot, T. Med. Sci. Monit. (2004) [Pubmed]
  30. Keratinocyte growth factor receptor expression in normal colorectal epithelial cells and differentiated type of colorectal cancer. Yoshino, M., Ishiwata, T., Watanabe, M., Komine, O., Shibuya, T., Tokunaga, A., Naito, Z. Oncol. Rep. (2005) [Pubmed]
  31. A rare case of metastases to the maxillary sinus from sigmoid colon adenocarcinoma. Cama, E., Agostino, S., Ricci, R., Scarano, E. ORL J. Otorhinolaryngol. Relat. Spec. (2002) [Pubmed]
  32. Quantification of cytokeratin 20, carcinoembryonic antigen and guanylyl cyclase C mRNA levels in lymph nodes may not predict treatment failure in colorectal cancer patients. Bustin, S.A., Siddiqi, S., Ahmed, S., Hands, R., Dorudi, S. Int. J. Cancer (2004) [Pubmed]
  33. Expression of cytokeratin 20 in mucinous bronchioloalveolar carcinoma. Shah, R.N., Badve, S., Papreddy, K., Schindler, S., Laskin, W.B., Yeldandi, A.V. Hum. Pathol. (2002) [Pubmed]
  34. Utility of cytokeratin 20 and Ki-67 as markers of urothelial dysplasia. Kunju, L.P., Lee, C.T., Montie, J., Shah, R.B. Pathol. Int. (2005) [Pubmed]
  35. Cytokeratin 20, AN43, PGDH, and COX-2 expression in transitional and squamous cell carcinoma of the bladder. Gee, J.R., Montoya, R.G., Khaled, H.M., Sabichi, A.L., Grossman, H.B. Urol. Oncol. (2003) [Pubmed]
  36. Differential expression of carcinoembryonic antigen (CEA) splice variants in whole blood of colon cancer patients and healthy volunteers: implication for the detection of circulating colon cancer cells. Hampton, R., Walker, M., Marshall, J., Juhl, H. Oncogene (2002) [Pubmed]
  37. Intrinsic variability in the detection of micrometastases in lymph nodes for re-staging of colorectal cancer. effect of individual markers and tissue samples. Salto-Tellez, M., Kong, S.L., Leong, A.P., Koay, E.S. Eur. J. Cancer (2003) [Pubmed]
  38. Impact of cytokeratin-20 and carcinoembryonic antigen mRNA detection by RT-PCR in regional lymph nodes of patients with colorectal cancer. Rosenberg, R., Hoos, A., Mueller, J., Nekarda, H. Br. J. Cancer (2000) [Pubmed]
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