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Gene Review

Abcc3  -  ATP-binding cassette, sub-family C...

Mus musculus

Synonyms: 1700019L09Rik, ABC31, ATP-binding cassette sub-family C member 3, Canalicular multispecific organic anion transporter 2, Cmoat2, ...
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Disease relevance of Abcc3

  • Reduction of endogenous VDR expression in colon adenocarcinoma MCA-38 cells by siRNA transfection was associated with reduced constitutive and inducible expression of the Mrp3 gene [1].

High impact information on Abcc3

  • This results in increased levels of M3G in liver and bile, a 50-fold reduction in the plasma levels of M3G, and in a major shift in the main disposition route for morphine and M3G, predominantly via the urine in WT mice but via the feces in Mrp3(-/-) mice [2].
  • Western analyses revealed that Mrp4, but not Mrp3, was significantly increased after CBDL in wild-type mice [3].
  • Because Mrp3 preferentially transports glucuronide conjugates, we investigated the in vivo disposition of acetaminophen (APAP) and its metabolites [4].
  • Mrp3+/+ and Mrp3-/- knockout mice received APAP (150 mg/kg), and bile was collected [4].
  • MRP3 is an ABC transporter localized in the basolateral membrane of epithelial cells such as hepatocytes and enterocytes [4].

Biological context of Abcc3


Anatomical context of Abcc3

  • The function of MRP3 in other tissues, notably the gut and the adrenal cortex, remains to be defined [7].

Associations of Abcc3 with chemical compounds


Other interactions of Abcc3

  • These results provide the first direct evidence that Mrp3 and Mrp4 participate in the hepatic basolateral excretion of sulfate conjugates, although additional mechanism(s) are likely involved [8].
  • Hepatic Abcc3 protein levels, determined by immunoblot analysis, were approximately 60% higher in Abcc2-/- mice than in wild-type mice [10].
  • The cellular location of another of the differentially expressed ABC transporters, Abcc3, was examined by immunohistochemistry [11].
  • The MRP/plf-mRNA species expressed in the skin were predominantly plf1 and mrp3 as determined by gene-specific restriction enzyme sites within the RT-PCR products [12].


  1. Vitamin D receptor-dependent regulation of colon multidrug resistance-associated protein 3 gene expression by bile acids. McCarthy, T.C., Li, X., Sinal, C.J. J. Biol. Chem. (2005) [Pubmed]
  2. Mice lacking multidrug resistance protein 3 show altered morphine pharmacokinetics and morphine-6-glucuronide antinociception. Zelcer, N., van de Wetering, K., Hillebrand, M., Sarton, E., Kuil, A., Wielinga, P.R., Tephly, T., Dahan, A., Beijnen, J.H., Borst, P. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  3. Mrp4-/- mice have an impaired cytoprotective response in obstructive cholestasis. Mennone, A., Soroka, C.J., Cai, S.Y., Harry, K., Adachi, M., Hagey, L., Schuetz, J.D., Boyer, J.L. Hepatology (2006) [Pubmed]
  4. Altered disposition of acetaminophen in mice with a disruption of the Mrp3 gene. Manautou, J.E., de Waart, D.R., Kunne, C., Zelcer, N., Goedken, M., Borst, P., Elferink, R.O. Hepatology (2005) [Pubmed]
  5. Tumor necrosis factor alpha-dependent up-regulation of Lrh-1 and Mrp3(Abcc3) reduces liver injury in obstructive cholestasis. Bohan, A., Chen, W.S., Denson, L.A., Held, M.A., Boyer, J.L. J. Biol. Chem. (2003) [Pubmed]
  6. Characterization of drug transport by the human multidrug resistance protein 3 (ABCC3). Zelcer, N., Saeki, T., Reid, G., Beijnen, J.H., Borst, P. J. Biol. Chem. (2001) [Pubmed]
  7. Multidrug resistance-associated proteins 3, 4, and 5. Borst, P., de Wolf, C., van de Wetering, K. Pflugers Arch. (2007) [Pubmed]
  8. Evaluation of the role of multidrug resistance-associated protein (mrp) 3 and mrp4 in hepatic basolateral excretion of sulfate and glucuronide metabolites of acetaminophen, 4-methylumbelliferone, and harmol in abcc3-/- and abcc4-/- mice. Zamek-Gliszczynski, M.J., Nezasa, K., Tian, X., Bridges, A.S., Lee, K., Belinsky, M.G., Kruh, G.D., Brouwer, K.L. J. Pharmacol. Exp. Ther. (2006) [Pubmed]
  9. Regulation of mRNA expression of xenobiotic transporters by the pregnane x receptor in mouse liver, kidney, and intestine. Cheng, X., Klaassen, C.D. Drug Metab. Dispos. (2006) [Pubmed]
  10. Altered hepatobiliary disposition of 5 (and 6)-carboxy-2',7'-dichlorofluorescein in Abcg2 (Bcrp1) and Abcc2 (Mrp2) knockout mice. Nezasa, K., Tian, X., Zamek-Gliszczynski, M.J., Patel, N.J., Raub, T.J., Brouwer, K.L. Drug Metab. Dispos. (2006) [Pubmed]
  11. Regional variations in ABC transporter expression along the mouse intestinal tract. Mutch, D.M., Anderle, P., Fiaux, M., Mansourian, R., Vidal, K., Wahli, W., Williamson, G., Roberts, M.A. Physiol. Genomics (2004) [Pubmed]
  12. Mitogen-regulated protein/proliferin mRNA induction following single applications of tumor promoters to murine skin. Parfett, C.L. Mol. Carcinog. (2005) [Pubmed]
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