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Chemical Compound Review

PREGNENOLONE CARBONITRILE     (3S,8R,9S,10R,13S,14S,16R,17S) -17-ethanoyl...

Synonyms: CCRIS 9224, AG-L-64254, CHEMBL1400945, SureCN1012160, BSPBio_001063, ...
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High impact information on PREGNENOLONE CARBONITRILE






Associations of PREGNENOLONE CARBONITRILE with other chemical compounds




Analytical, diagnostic and therapeutic context of PREGNENOLONE CARBONITRILE


  1. In vivo antitumor activity and host toxicity of methoxymorpholinyl doxorubicin: role of cytochrome P450 3A. Quintieri, L., Rosato, A., Napoli, E., Sola, F., Geroni, C., Floreani, M., Zanovello, P. Cancer Res. (2000) [Pubmed]
  2. Promotion of thyroid tumors in rats by pregnenolone-16alpha-carbonitrile (PCN) and polychlorinated biphenyl (PCB). Vansell, N.R., Muppidi, J.R., Habeebu, S.M., Klaassen, C.D. Toxicol. Sci. (2004) [Pubmed]
  3. Phenobarbital, beta-naphthoflavone, clofibrate, and pregnenolone-16alpha-carbonitrile do not affect hepatic thyroid hormone UDP-glucuronosyl transferase activity, and thyroid gland function in mice. Viollon-Abadie, C., Lassere, D., Debruyne, E., Nicod, L., Carmichael, N., Richert, L. Toxicol. Appl. Pharmacol. (1999) [Pubmed]
  4. Coordinate regulation of xenobiotic and bile acid homeostasis by pregnane X receptor. Staudinger, J., Liu, Y., Madan, A., Habeebu, S., Klaassen, C.D. Drug Metab. Dispos. (2001) [Pubmed]
  5. Humanized xenobiotic response in mice expressing nuclear receptor SXR. Xie, W., Barwick, J.L., Downes, M., Blumberg, B., Simon, C.M., Nelson, M.C., Neuschwander-Tetri, B.A., Brunt, E.M., Guzelian, P.S., Evans, R.M. Nature (2000) [Pubmed]
  6. Differential effects of microsomal enzyme-inducing chemicals on the hepatic expression of rat organic anion transporters, OATP1 and OATP2. Rausch-Derra, L.C., Hartley, D.P., Meier, P.J., Klaassen, C.D. Hepatology (2001) [Pubmed]
  7. Oltipraz-mediated changes in aflatoxin B(1) biotransformation in rat liver: implications for human chemointervention. Buetler, T.M., Bammler, T.K., Hayes, J.D., Eaton, D.L. Cancer Res. (1996) [Pubmed]
  8. Dimethylnitrosamine-induced inhibition of hepatic protein synthesis in vitro and the effect of pretreatment with cystamine or pregnenolone-16alpha-carbonitrile. Kleihues, P., Margison, J.M., Margison, G.P. Cancer Res. (1975) [Pubmed]
  9. Tissue-specific, inducible, and hormonal control of the human UDP-glucuronosyltransferase-1 (UGT1) locus. Chen, S., Beaton, D., Nguyen, N., Senekeo-Effenberger, K., Brace-Sinnokrak, E., Argikar, U., Remmel, R.P., Trottier, J., Barbier, O., Ritter, J.K., Tukey, R.H. J. Biol. Chem. (2005) [Pubmed]
  10. Nuclear Pregnane X Receptor Cross-talk with FoxA2 to Mediate Drug-induced Regulation of Lipid Metabolism in Fasting Mouse Liver. Nakamura, K., Moore, R., Negishi, M., Sueyoshi, T. J. Biol. Chem. (2007) [Pubmed]
  11. Induction of rat organic anion transporting polypeptide 2 by pregnenolone-16alpha-carbonitrile is via interaction with pregnane X receptor. Guo, G.L., Staudinger, J., Ogura, K., Klaassen, C.D. Mol. Pharmacol. (2002) [Pubmed]
  12. Pregnane X receptor up-regulation of P-glycoprotein expression and transport function at the blood-brain barrier. Bauer, B., Hartz, A.M., Fricker, G., Miller, D.S. Mol. Pharmacol. (2004) [Pubmed]
  13. Clofibrate and perfluorodecanoate both upregulate the expression of the pregnane X receptor but oppositely affect its ligand-dependent induction on cytochrome P450 3A23. Ma, Y., Sachdeva, K., Liu, J., Song, X., Li, Y., Yang, D., Deng, R., Chichester, C.O., Yan, B. Biochem. Pharmacol. (2005) [Pubmed]
  14. The role of protein synthesis and degradation in the post-transcriptional regulation of rat multidrug resistance-associated protein 2 (Mrp2, Abcc2). Jones, B.R., Li, W., Cao, J., Hoffman, T.A., Gerk, P.M., Vore, M. Mol. Pharmacol. (2005) [Pubmed]
  15. Xenobiotic- and vitamin D-responsive induction of the steroid/bile acid-sulfotransferase Sult2A1 in young and old mice: The role of a gene enhancer in the liver chromatin. Seo, Y.K., Chung, Y.T., Kim, S., Echchgadda, I., Song, C.S., Chatterjee, B. Gene (2007) [Pubmed]
  16. P-glycoprotein and an unstirred water layer barring digoxin absorption in the vascularly perfused rat small intestine preparation: induction studies with pregnenolone-16alpha-carbonitrile. Liu, S., Tam, D., Chen, X., Pang, K.S. Drug Metab. Dispos. (2006) [Pubmed]
  17. The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity. Staudinger, J.L., Goodwin, B., Jones, S.A., Hawkins-Brown, D., MacKenzie, K.I., LaTour, A., Liu, Y., Klaassen, C.D., Brown, K.K., Reinhard, J., Willson, T.M., Koller, B.H., Kliewer, S.A. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  18. Regulation of mRNA expression of xenobiotic transporters by the pregnane x receptor in mouse liver, kidney, and intestine. Cheng, X., Klaassen, C.D. Drug Metab. Dispos. (2006) [Pubmed]
  19. Orphan nuclear receptor pregnane X receptor sensitizes oxidative stress responses in transgenic mice and cancerous cells. Gong, H., Singh, S.V., Singh, S.P., Mu, Y., Lee, J.H., Saini, S.P., Toma, D., Ren, S., Kagan, V.E., Day, B.W., Zimniak, P., Xie, W. Mol. Endocrinol. (2006) [Pubmed]
  20. Simultaneous substitution of phenylalanine-305 and aspartate-318 of rat pregnane X receptor with the corresponding human residues abolishes the ability to transactivate the CYP3A23 promoter. Song, X., Li, Y., Liu, J., Mukundan, M., Yan, B. J. Pharmacol. Exp. Ther. (2005) [Pubmed]
  21. Microarray analysis on Phase II drug metabolizing enzymes expression in pregnant rats after treatment with pregnenolone-16alpha-carbonitrile or phenobarbital. Ejiri, N., Katayama, K., Kiyosawa, N., Baba, Y., Doi, K. Exp. Mol. Pathol. (2005) [Pubmed]
  22. Identification by differential display of the IF1 inhibitor peptide of ATP synthase/ATPase as a gene inducible in rat liver by pregnenolone 16alpha-carbonitrile. Jiménez, B.D., Quattrochi, L.C., Yockey, C.B., Guzelian, P.S. Life Sci. (2000) [Pubmed]
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