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Gene Review

Spz1  -  spermatogenic leucine zipper 1

Mus musculus

Synonyms: 1700027M20Rik, AI429130, BHLH-Zip transcription factor SPZ1, Spermatogenic Zip 1, Spermatogenic leucine zipper protein 1
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High impact information on Spz1


Biological context of Spz1


Anatomical context of Spz1


Other interactions of Spz1

  • Further analysis showed that the expression of zygotically activated genes such as Interferon-gamma, Dub-1, Spz1, DD2106 (unknown gene), and DD2111 (unknown gene) were suppressed in NT embryos, suggesting that the cellular process involved in the nuclear reprogramming of somatic nucleus is not appropriately regulated [6].

Analytical, diagnostic and therapeutic context of Spz1

  • In the testes of transgenic mice, Spz1 proteins were found to be overexpressed in both germ and somatic cells as determined by immunofluorescence staining [3].
  • We identified that Spz1 is ectopically expressed in multiple tissues of transgenic male mice by Western blot analysis [3].
  • The ability of Spz1 protein to bind to the bHLH consensus-binding site, the E-box, was confirmed by EMSA, and a 9-bp asymmetric target site was identified by random selection and PCR amplification [5].


  1. bHLH-zip transcription factor Spz1 mediates mitogen-activated protein kinase cell proliferation, transformation, and tumorigenesis. Hsu, S.H., Hsieh-Li, H.M., Huang, H.Y., Huang, P.H., Li, H. Cancer Res. (2005) [Pubmed]
  2. Identification of the spermatogenic zip protein Spz1 as a putative protein phosphatase-1 (PP1) regulatory protein that specifically binds the PP1cgamma2 splice variant in mouse testis. Hrabchak, C., Varmuza, S. J. Biol. Chem. (2004) [Pubmed]
  3. Dysfunctional spermatogenesis in transgenic mice overexpressing bHLH-Zip transcription factor, Spz1. Hsu, S.H., Hsieh-Li, H.M., Li, H. Exp. Cell Res. (2004) [Pubmed]
  4. Expression of a novel bHLH-Zip gene in human testis. Sha, J.H., Zhou, Z.M., Li, J.M., Lin, M., Zhu, H., Zhu, H., Zhou, Y.D., Wang, L.L., Wang, Y.Q., Zhou, K.Y. Asian J. Androl. (2003) [Pubmed]
  5. Spz1, a novel bHLH-Zip protein, is specifically expressed in testis. Hsu, S.H., Shyu, H.W., Hsieh-Li, H.M., Li, H. Mech. Dev. (2001) [Pubmed]
  6. Zygotically activated genes are suppressed in mouse nuclear transferred embryos. Suzuki, T., Minami, N., Kono, T., Imai, H. Cloning Stem Cells (2006) [Pubmed]
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