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Gene Review

TUSC3  -  tumor suppressor candidate 3

Homo sapiens

Synonyms: D8S1992, M33, MGC13453, MRT22, MRT7, ...
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Disease relevance of TUSC3

  • Clone HRF-2 showed a high degree of identity with exons 9, 10 and 11 of N33, a gene that is located within a homozygously deleted region of metastatic prostate cancer [1].
  • Five genes from chromosomal band 8p22 are significantly down-regulated in ovarian carcinoma: N33 and EFA6R have a potential impact on overall survival [2].
  • Concordant methylation of the ER and N33 genes in glioblastoma multiforme [3].
  • FabG of R. leguminosarum and NodG of Rhizobium sp. N33 were expressed in Escherichia coli [4].
  • The N-terminal amino acid sequence of a 29-kDa protein that interacts strongly with NodF revealed high similarity to NodG of Rhizobium sp. N33 and to NodG of Sinorhizobium meliloti We cloned and sequenced the gene coding for the NodG-like protein of R. leguminosarum and found it to be the product of the constitutively expressed gene fabG [4].

Psychiatry related information on TUSC3


High impact information on TUSC3

  • The transcript map of the deletion interval now includes two known genes (MSR and N33) and six novel ESTs [6].
  • The N33 gene showed partial methylation in normal colon mucosa, which was age-related (r = 0.7; P = 0.003 using regression analysis) [7].
  • ER and N33 methylation in GBM may therefore appear as a result of shared etiologic factors, which may relate in part to aging cell populations in the brain [3].
  • Of the nine genes found to be overexpressed in fibroblastic mesothelial cells, three are matrix-associated (integrin alpha5, collagen binding protein 2, human cartilage glycoprotein 39), whereas the others are associated with a proliferative cell type (14-3-3 epsilon, plexin B2, N33, and three genes encoding ribosomal elements) [8].
  • Our data allow definition of an interval of common deletion, flanked by the loci D8S511 and D8S1992, where the putative tumor-suppressor gene might be localized [9].

Biological context of TUSC3


Anatomical context of TUSC3

  • In addition, N33 and EFA6R showed a complete loss of expression in several ovarian cancer cell lines [2].
  • The deletion, in pancreatic tumor cell line MIA-PaCa-2, encompassed two screening loci, D8S549 and D8S1992, and overlapped another previously described homozygous deletion of band 8p22 in a metastatic prostate cancer specimen [13].
  • The origin of N33 is thought to be similar to N18 from median nerve stimulation, which originates from brainstem activity below the thalamus [14].
  • The cerebral distribution of the initial cortical response (N33-P40) to stimulation of muscle afferents largely paralleled that to stimulation of its parent nerve, the posterior tibial nerve (which contains afferents of muscle, cutaneous and joint origin) [15].

Associations of TUSC3 with chemical compounds

  • Unhydroxylated N33 alpha-chains also reacted with Jacalin, confirming that the abnormal modification was O-glycosylation and not hyperhydroxylation of proline or lysine [16].
  • The effect of STP on later SEP cortical components depended on their scalp topography: parietal N33 and P45 underwent significant changes in both latency and amplitude, whereas precentral N30 showed a significant amplitude increase only [17].

Other interactions of TUSC3

  • RESULTS: Two genes showed a significantly (P< 0.05) lower expression in grade 3 tumors compared with tumors of lower grade (N33) or compared with normal controls and tumors with lower grade (EFA6R) [2].


  1. Differential display analysis of oxygen-mediated changes in gene expression in first trimester human trophoblast cells. Pak, B.J., Park, H., Chang, E.R., Pang, S.C., Graham, C.H. Placenta (1998) [Pubmed]
  2. Five genes from chromosomal band 8p22 are significantly down-regulated in ovarian carcinoma: N33 and EFA6R have a potential impact on overall survival. Pils, D., Horak, P., Gleiss, A., Sax, C., Fabjani, G., Moebus, V.J., Zielinski, C., Reinthaller, A., Zeillinger, R., Krainer, M. Cancer (2005) [Pubmed]
  3. Concordant methylation of the ER and N33 genes in glioblastoma multiforme. Li, Q., Jedlicka, A., Ahuja, N., Gibbons, M.C., Baylin, S.B., Burger, P.C., Issa, J.P. Oncogene (1998) [Pubmed]
  4. The nodulation protein NodG shows the enzymatic activity of an 3-oxoacyl-acyl carrier protein reductase. López-Lara, I.M., Geiger, O. Mol. Plant Microbe Interact. (2001) [Pubmed]
  5. Evoked potentials in patients with Huntington's disease and their offspring. I. Somatosensory evoked potentials. Noth, J., Engel, L., Friedemann, H.H., Lange, H.W. Electroencephalography and clinical neurophysiology. (1984) [Pubmed]
  6. High-resolution physical map and transcript identification of a prostate cancer deletion interval on 8p22. Arbieva, Z.H., Banerjee, K., Kim, S.Y., Edassery, S.L., Maniatis, V.S., Horrigan, S.K., Westbrook, C.A. Genome Res. (2000) [Pubmed]
  7. Aging and DNA methylation in colorectal mucosa and cancer. Ahuja, N., Li, Q., Mohan, A.L., Baylin, S.B., Issa, J.P. Cancer Res. (1998) [Pubmed]
  8. Mesothelial differentiation as reflected by differential gene expression. Sun, X., Gulyás, M., Hjerpe, A. Am. J. Respir. Cell Mol. Biol. (2004) [Pubmed]
  9. Fine deletion mapping of chromosome 8p in non-small-cell lung carcinoma. Lerebours, F., Olschwang, S., Thuille, B., Schmitz, A., Fouchet, P., Buecher, B., Martinet, N., Galateau, F., Thomas, G. Int. J. Cancer (1999) [Pubmed]
  10. Physical mapping of chromosome 8p22 markers and their homozygous deletion in a metastatic prostate cancer. Bova, G.S., MacGrogan, D., Levy, A., Pin, S.S., Bookstein, R., Isaacs, W.B. Genomics (1996) [Pubmed]
  11. High frequency of allelic imbalance at regions of chromosome arm 8p in ovarian carcinoma. Pribill, I., Speiser, P., Leary, J., Leodolter, S., Hacker, N.F., Friedlander, M.L., Birnbaum, D., Zeillinger, R., Krainer, M. Cancer Genet. Cytogenet. (2001) [Pubmed]
  12. P30 and N33 of posterior tibial nerve SSEPs are analogous to P14 and N18 of median nerve SSEPs. Urasaki, E., Tokimura, T., Yasukouchi, H., Wada, S., Yokota, A. Electroencephalography and clinical neurophysiology. (1993) [Pubmed]
  13. High-density screen of human tumor cell lines for homozygous deletions of loci on chromosome arm 8p. Levy, A., Dang, U.C., Bookstein, R. Genes Chromosomes Cancer (1999) [Pubmed]
  14. Origin of subcortical somatosensory evoked potentials in response to posterior tibial nerve stimulation in humans. Urasaki, E., Wada, S., Yokota, A., Tokimura, T., Yasukouchi, H. J. UOEH (1993) [Pubmed]
  15. The cortical distribution of muscle and cutaneous afferent projections from the human foot. Macefield, G., Burke, D., Gandevia, S.C. Electroencephalography and clinical neurophysiology. (1989) [Pubmed]
  16. Aberrant O-glycosylation in the collagenous domain of pro alpha2(I) procollagen subunits synthesized by chemically transformed hamster fibroblasts. Ramachandran, U., Peterkofsky, B. Arch. Biochem. Biophys. (1997) [Pubmed]
  17. Anesthetic induction with thiopental: its effect on scalp topography of median nerve somatosensory evoked potentials. Pinto, F., Ragazzoni, A., Amantini, A., de Scisciolo, G., Bartelli, M., Rossi, R., Pieraccioli, E. Acta anaesthesiologica Scandinavica. (1990) [Pubmed]
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