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MeSH Review

Tibial Nerve

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Disease relevance of Tibial Nerve


Psychiatry related information on Tibial Nerve


High impact information on Tibial Nerve


Chemical compound and disease context of Tibial Nerve


Biological context of Tibial Nerve

  • METHODS: More than 6 months after an acute SCI, clinical follow-up examinations were paralleled by electrophysiologic recordings with tibial nerve stimulation (M-wave, F-wave, H-reflex, and flexor reflex) [14].
  • In the sciatic system of rats with streptozocin (SZ)-induced diabetes, delay of axonal transport of neurofilament (NF) proteins, tubulin, and other proteins is associated with a change in axonal caliber, which increases by 40% in lumbar motor roots and decreases by 36% in tibial nerves [15].
  • Bilateral radio-frequency lesions of the 'glycine-sensitive area' similarly lowered blood pressure and heart rate, blocked the fastigial pressor response and abolished renal nerve responses to fastigial nucleus or tibial nerve stimulation [16].
  • Topical application of capsaicin (1%) on the tibial nerve did not affect SCS-induced vasodilation at 30 and 60% of motor threshold (MT) [17].
  • The effects of anesthetic technique (nitrous oxide or propofol) and high-pass digital filtering on within-patient variability of posterior tibial nerve somatosensory cortical evoked potentials (PTN-SCEP) were compared prospectively in two groups of 20 patients undergoing spinal surgery [18].

Anatomical context of Tibial Nerve


Associations of Tibial Nerve with chemical compounds

  • EMG recordings after both sural and tibial nerve stimulation showed that distinct early and late ipsilateral flexor muscle responses could be elicited [24].
  • Serum lipoperoxide concentrations, tibial nerve lipoperoxide content and serum TNF-alpha activity induced by lipopolysaccharide was increased in diabetic rats, but inhibited in troglitazone-treated rats [25].
  • We examined, in anaesthetized (ketamine/xylazine) rats, the properties of motoneurones with axons in the tibial nerve, from rats performing daily spontaneous running exercise for 12 weeks in exercise wheels ('runners') and from rats confined to plastic cages ('controls') [26].
  • To characterize further properties of monosaccharide transport at the BNB, unidirectional transfer constant (K) values were determined in vivo in tibial nerve of anesthetized rats for radiolabeled mannitol, L-glucose, and a series of D-glucose analogs [27].
  • Neurotoxicity in rat tibial nerve was assessed following injections of lidocaine through implanted catheters [28].

Gene context of Tibial Nerve

  • Acrylamide inhibited activity of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in sciatic and tibial nerves, as well as in brain [29].
  • 5. In muscles in which ectopic NMJs had formed after cutting the tibial nerve, the amounts of ACh and ChAT were about one-fifth of those in the regions of innervation of control muscles [30].
  • After posterior tibial nerve stimulation, the following waveforms are recorded: N22, W3, the dorsal column volley, N29, P31, N34, and P37 [31].
  • After stimulation of the lower extremity nerve (tibial nerve), N21 and N23 are recorded from L4 and T12 spine respectively [32].
  • The greatest number of abnormalities was disclosed by measurement of CMCT followed by SEPs after tibial nerve stimulation [33].

Analytical, diagnostic and therapeutic context of Tibial Nerve


  1. Correlation of SEP abnormalities with brain and cervical cord MRI in multiple sclerosis. Turano, G., Jones, S.J., Miller, D.H., Du Boulay, G.H., Kakigi, R., McDonald, W.I. Brain (1991) [Pubmed]
  2. Adrenergic innervation of blood vessels in rat tibial nerve during Wallerian degeneration. Koistinaho, J., Wadhwani, K.C., Latker, C.H., Balbo, A., Rapoport, S.I. Acta Neuropathol. (1990) [Pubmed]
  3. Post-traumatic alterations in glutamine synthetase activity in peripheral and central nerves. Politis, M.J., Miller, J.E. Brain Res. (1985) [Pubmed]
  4. Across-tarsal-tunnel motor-nerve conduction technique. Felsenthal, G., Butler, D.H., Shear, M.S. Archives of physical medicine and rehabilitation. (1992) [Pubmed]
  5. Treatment of upper motoneuron plantarflexion contractures by using an adjustable ankle-foot orthosis. Grissom, S.P., Blanton, S. Archives of physical medicine and rehabilitation. (2001) [Pubmed]
  6. Classical conditioning of a flexor nerve response in spinal cats: effects of tibial nerve CS and a differential conditioning paradigm. Beggs, A.L., Steinmetz, J.E., Patterson, M.M. Behav. Neurosci. (1985) [Pubmed]
  7. Evoked potentials in patients with Huntington's disease and their offspring. I. Somatosensory evoked potentials. Noth, J., Engel, L., Friedemann, H.H., Lange, H.W. Electroencephalography and clinical neurophysiology. (1984) [Pubmed]
  8. Nerve conduction abnormalities in untreated maturity-onset diabetes: relation to levels of fasting plasma glucose and glycosylated hemoglobin. Graf, R.J., Halter, J.B., Halar, E., Porte, D. Ann. Intern. Med. (1979) [Pubmed]
  9. Distal neuropathy in experimental diabetes mellitus. Brown, M.J., Sumner, A.J., Greene, D.A., Diamond, S.M., Asbury, A.K. Ann. Neurol. (1980) [Pubmed]
  10. Clinical and neurophysiological studies of aldose reductase inhibitor ponalrestat in chronic symptomatic diabetic peripheral neuropathy. Florkowski, C.M., Rowe, B.R., Nightingale, S., Harvey, T.C., Barnett, A.H. Diabetes (1991) [Pubmed]
  11. Lethal retrograde axoplasmic transport of doxorubicin (adriamycin) to motor neurons. A toxic motor neuronopathy. England, J.D., Asbury, A.K., Rhee, E.K., Sumner, A.J. Brain (1988) [Pubmed]
  12. Enhancement of sensitivity to acrylamide after nerve ligature. Cavanagh, J.B. Acta neuropathologica. Supplementum. (1981) [Pubmed]
  13. Spinal and cortical evoked potentials following stimulation of the posterior tibial nerve in the diagnosis and localization of spinal cord diseases. Riffel, B., Stöhr, M., Körner, S. Electroencephalography and clinical neurophysiology. (1984) [Pubmed]
  14. From spinal shock to spasticity: neuronal adaptations to a spinal cord injury. Hiersemenzel, L.P., Curt, A., Dietz, V. Neurology (2000) [Pubmed]
  15. Changes in axon size and slow axonal transport are related in experimental diabetic neuropathy. Medori, R., Autilio-Gambetti, L., Jenich, H., Gambetti, P. Neurology (1988) [Pubmed]
  16. Mediation of the fastigial pressor response and a somatosympathetic reflex by ventral medullary neurones in the cat. McAllen, R.M. J. Physiol. (Lond.) (1985) [Pubmed]
  17. Role of primary afferents in spinal cord stimulation-induced vasodilation: characterization of fiber types. Tanaka, S., Barron, K.W., Chandler, M.J., Linderoth, B., Foreman, R.D. Brain Res. (2003) [Pubmed]
  18. Variability of somatosensory cortical evoked potentials during spinal surgery. Effects of anesthetic technique and high-pass digital filtering. Kalkman, C.J., ten Brink, S.A., Been, H.D., Bovill, J.G. Spine. (1991) [Pubmed]
  19. In vitro studies of the substrates for energy production and the effects of insulin on glucose utilization in the neural components of peripheral nerve. Greene, D.A., Winegrad, A.I. Diabetes (1979) [Pubmed]
  20. Only limited effects of aminoguanidine treatment on peripheral nerve function, (Na+,K+)-ATPase activity and thrombomodulin expression in streptozotocin-induced diabetic rats. Wada, R., Sugo, M., Nakano, M., Yagihashi, S. Diabetologia (1999) [Pubmed]
  21. Organization of motor units following cross-reinnervation of antagonistic muscles in the cat hind limb. Gordon, T., Stein, R.B., Thomas, C.K. J. Physiol. (Lond.) (1986) [Pubmed]
  22. Rubidium uptake and accumulation in peripheral myelinated internodal axons and Schwann cells. Lehning, E.J., Gaughan, C.L., Eichberg, J., LoPachin, R.M. J. Neurochem. (1997) [Pubmed]
  23. Transcutaneous posterior tibial nerve stimulation for treatment of detrusor hyperreflexia in spinal cord injury. Andrews, B.J., Reynard, J.M. J. Urol. (2003) [Pubmed]
  24. Long-latency spinal reflex in man after flexor reflex afferent stimulation. Roby-Brami, A., Bussel, B. Brain (1987) [Pubmed]
  25. Inhibitory effect of troglitazone on diabetic neuropathy in streptozotocin-induced diabetic rats. Qiang, X., Satoh, J., Sagara, M., Fukuzawa, M., Masuda, T., Sakata, Y., Muto, G., Muto, Y., Takahashi, K., Toyota, T. Diabetologia (1998) [Pubmed]
  26. Effects of daily spontaneous running on the electrophysiological properties of hindlimb motoneurones in rats. Beaumont, E., Gardiner, P. J. Physiol. (Lond.) (2002) [Pubmed]
  27. Structural specificity of sugar transport at the blood-nerve barrier. Rechthand, E., Smith, Q.R., Rapoport, S.I. J. Neurochem. (1989) [Pubmed]
  28. Effect of repetitive lidocaine infusion on peripheral nerve. Kroin, J.S., Penn, R.D., Levy, F.E., Kerns, J.M. Exp. Neurol. (1986) [Pubmed]
  29. Evaluation of the neurotoxicity of glycidamide, an epoxide metabolite of acrylamide: behavioral, neurochemical and morphological studies. Costa, L.G., Deng, H., Calleman, C.J., Bergmark, E. Toxicology (1995) [Pubmed]
  30. Release and synthesis of acetylcholine at ectopic neuromuscular junctions in the rat. van Kempen, G.T., Molenaar, P.C., Slater, C.R. J. Physiol. (Lond.) (1994) [Pubmed]
  31. Generators of short latency human somatosensory-evoked potentials recorded over the spine and scalp. Lee, E.K., Seyal, M. Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society. (1998) [Pubmed]
  32. Neuroanatomic substrates of lower extremity somatosensory evoked potentials. Yamada, T. Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society. (2000) [Pubmed]
  33. SEPs and CNS magnetic stimulation in syringomyelia. Nogués, M.A., Pardal, A.M., Merello, M., Miguel, M.A. Muscle Nerve (1992) [Pubmed]
  34. Analgesic doses of morphine do not reduce noxious stimulus-evoked release of immunoreactive neurokinins in the dorsal horn of the spinal cat. Lang, C.W., Duggan, A.W., Hope, P.J. Br. J. Pharmacol. (1991) [Pubmed]
  35. Stellate ganglion block is associated with increased tibial nerve muscle sympathetic activity in humans. Ikeda, T., Iwase, S., Sugiyama, Y., Matsukawa, T., Mano, T., Doi, M., Kikura, M., Ikeda, K. Anesthesiology (1996) [Pubmed]
  36. Acrylamide-induced ascending degeneration of ligated peripheral nerve: effect of ligature location. Sharer, L.R., Lowndes, H.E. Neuropathol. Appl. Neurobiol. (1985) [Pubmed]
  37. The expression of proinflammatory cytokine mRNA in the sciatic-tibial nerve of ischemia-reperfusion injury. Mitsui, Y., Okamoto, K., Martin, D.P., Schmelzer, J.D., Low, P.A. Brain Res. (1999) [Pubmed]
  38. Effects of chondroitinase ABC on intrathecal and peripheral nerve tissue. An in vivo experimental study on rabbits. Olmarker, K., Danielsen, N., Nordborg, C., Rydevik, B. Spine. (1991) [Pubmed]
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