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RND2  -  Rho family GTPase 2

Homo sapiens

Synonyms: ARHN, RHO7, Rho-related GTP-binding protein Rho7, Rho-related GTP-binding protein RhoN, Rho7, ...
 
 
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High impact information on RND2

  • Diminished protein levels of the microtubule-associated protein MAP1B and increased levels of the GTP-binding protein RND2 were confirmed in the developing cortex in vivo and in primary hippocampal neurons in vitro [1].
  • In addition to BRCA1, the contig contains two complete genes: Rho7, a member of the rho family of GTP binding proteins, and VAT1, an abundant membrane protein of cholinergic synaptic vesicles [2].
  • In PC12 cells, expressing Pragmin inhibits nerve growth factor-induced neurite outgrowth in response to Rnd2, and knock-down of Pragmin by Pragmin-specific small interfering RNA enhances neurite elongation [3].
  • Identification of splicing variants of Rapostlin, a novel RND2 effector that interacts with neural Wiskott-Aldrich syndrome protein and induces neurite branching [4].
  • We demonstrated a significant increase in the gene expression of several important functional groups of CB genes compared with basal levels including cytokine (IL-12p40, 5-fold), immunoregulatory (signaling lymphocytic activation molecule, 4-fold), signal transduction (Pim-2, 3-fold), and cell structure (Rho7, 4-fold) among others [5].
 

Biological context of RND2

 

Anatomical context of RND2

  • Therefore, Rapostlin is the first effector of Rnd2, regulating neurite branch formation [7].
  • When Rnd2 was co-expressed with Vps4-A(E228Q), Rnd2 was recruited to the Vps4-A-bound early endosomes [8].
  • We conclude that Rnd2 is a probable physiological partner of MgcRacGAP in male germ cells and we propose that MgcRacGAP, and, quite possibly, other RhoGAPs, may participate in signalling pathways involving Rnd family proteins [9].
  • Rnd1 promotes spine maturation, and Rnd2 stimulates dendrite branching through its specific effector, Rapostlin [10].
 

Associations of RND2 with chemical compounds

 

Physical interactions of RND2

  • These results suggest that Rnd2 is involved in the regulation of endosomal trafficking via direct binding to Vps4-A [8].

References

  1. COUP-TFI is required for the formation of commissural projections in the forebrain by regulating axonal growth. Armentano, M., Filosa, A., Andolfi, G., Studer, M. Development (2006) [Pubmed]
  2. Complete genomic sequence and analysis of 117 kb of human DNA containing the gene BRCA1. Smith, T.M., Lee, M.K., Szabo, C.I., Jerome, N., McEuen, M., Taylor, M., Hood, L., King, M.C. Genome Res. (1996) [Pubmed]
  3. Pragmin, a novel effector of Rnd2 GTPase, stimulates RhoA activity. Tanaka, H., Katoh, H., Negishi, M. J. Biol. Chem. (2006) [Pubmed]
  4. Identification of splicing variants of Rapostlin, a novel RND2 effector that interacts with neural Wiskott-Aldrich syndrome protein and induces neurite branching. Kakimoto, T., Katoh, H., Negishi, M. J. Biol. Chem. (2004) [Pubmed]
  5. Differential gene expression patterns by oligonucleotide microarray of basal versus lipopolysaccharide-activated monocytes from cord blood versus adult peripheral blood. Jiang, H., Van De Ven, C., Satwani, P., Baxi, L.V., Cairo, M.S. J. Immunol. (2004) [Pubmed]
  6. Expression of RND proteins in human myometrium. Lartey, J., Gampel, A., Pawade, J., Mellor, H., Bernal, A.L. Biol. Reprod. (2006) [Pubmed]
  7. Rapostlin is a novel effector of Rnd2 GTPase inducing neurite branching. Fujita, H., Katoh, H., Ishikawa, Y., Mori, K., Negishi, M. J. Biol. Chem. (2002) [Pubmed]
  8. Vps4-A (vacuolar protein sorting 4-A) is a binding partner for a novel Rho family GTPase, Rnd2. Tanaka, H., Fujita, H., Katoh, H., Mori, K., Negishi, M. Biochem. J. (2002) [Pubmed]
  9. Rho family GTPase Rnd2 interacts and co-localizes with MgcRacGAP in male germ cells. Naud, N., Touré, A., Liu, J., Pineau, C., Morin, L., Dorseuil, O., Escalier, D., Chardin, P., Gacon, G. Biochem. J. (2003) [Pubmed]
  10. Rho family GTPases and dendrite plasticity. Negishi, M., Katoh, H. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. (2005) [Pubmed]
 
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